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Virology Journal
Published in: Virology Journal 1/2020

01-12-2020 | Lymphoma | Review

Long noncoding RNAs involvement in Epstein-Barr virus infection and tumorigenesis

Authors: Jing Zhang, Xiaohan Li, Jingjin Hu, Pengfei Cao, Qijia Yan, Siwei Zhang, Wei Dang, Jianhong Lu

Published in: Virology Journal | Issue 1/2020

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Abstract

The Epstein-Barr virus (EBV) is a ubiquitous γ-herpesvirus related to various types of cancers, including epithelial nasopharyngeal carcinoma, gastric carcinoma, and lymphoma. Long noncoding RNAs (lncRNAs) are expressed extensively in mammalian cells and play crucial roles in regulating various cellular processes and multiple cancers. Cellular lncRNAs can be differentially expressed induced by EBV infection. The dysregulated lncRNAs probably modulate the host immune response and other biological functions. At present, lncRNAs have been found to be significantly increased or decreased in EBV-infected cells, exosomes and EBV-associated cancers, suggesting their potential function and clinical application as biomarkers. In addition, EBV-encoded lncRNAs, BART and BHLF1 lncRNAs, may play roles in the viral oncogenesis. Analysis of the specific lncRNAs involved in interactions with the EBV machinery will provide information on their potential mechanism of action during multiple steps of EBV tumorigenesis. Here, we review the current knowledge regarding EBV-related lncRNAs and their possible roles in the pathogenesis of EBV-associated cancers.
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Metadata
Title
Long noncoding RNAs involvement in Epstein-Barr virus infection and tumorigenesis
Authors
Jing Zhang
Xiaohan Li
Jingjin Hu
Pengfei Cao
Qijia Yan
Siwei Zhang
Wei Dang
Jianhong Lu
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Virology Journal / Issue 1/2020
Electronic ISSN: 1743-422X
DOI
https://doi.org/10.1186/s12985-020-01308-y

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