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Virology Journal
Published in: Virology Journal 1/2015

Open Access 01-12-2015 | Review

Tackling dengue fever: Current status and challenges

Authors: Taoufik Nedjadi, Sherif El-Kafrawy, Sayed S. Sohrab, Philippe Desprès, Ghazi Damanhouri, Esam Azhar

Published in: Virology Journal | Issue 1/2015

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Abstract

According to recent statistics, 96 million apparent dengue infections were estimated worldwide in 2010. This figure is by far greater than the WHO prediction which indicates the rapid spread of this disease posing a growing threat to the economy and a major challenge to clinicians and health care services across the globe particularly in the affected areas.
This article aims at bringing to light the current epidemiological and clinical status of the dengue fever. The relationship between genetic mutations, single nucleotide polymorphism (SNP) and the pathophysiology of disease progression will be put into perspective. It will also highlight the recent advances in dengue vaccine development.
Thus far, a significant progress has been made in unraveling the risk factors and understanding the molecular pathogenesis associated with the disease. However, further insights in molecular features of the disease and the development of animal models will enormously help improving the therapeutic interventions and potentially contribute to finding new preventive measures for population at risk.
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Metadata
Title
Tackling dengue fever: Current status and challenges
Authors
Taoufik Nedjadi
Sherif El-Kafrawy
Sayed S. Sohrab
Philippe Desprès
Ghazi Damanhouri
Esam Azhar
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Virology Journal / Issue 1/2015
Electronic ISSN: 1743-422X
DOI
https://doi.org/10.1186/s12985-015-0444-8

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