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Open Access 01-12-2017 | Review

Development of an anti-HIV vaccine eliciting broadly neutralizing antibodies

Authors: Yousuf Ahmed, Meijuan Tian, Yong Gao

Published in: AIDS Research and Therapy | Issue 1/2017

Abstract

The extreme HIV diversity posts a great challenge on development of an effective anti-HIV vaccine. To solve this problem, it is crucial to discover an appropriate immunogens and strategies that are able to prevent the transmission of the diverse viruses that are circulating in the world. Even though there have been a number of broadly neutralizing anti-HIV antibodies (bNAbs) been discovered in recent years, induction of such antibodies to date has only been observed in HIV-1 infection. Here, in this mini review, we review the progress in development of HIV vaccine in eliciting broad immune response, especially production of bNAbs, discuss possible strategies, such as polyvalent sequential vaccination, that facilitates B cell maturation leading to bNAb response.

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Title: Development of an anti-HIV vaccine eliciting broadly neutralizing antibodies
Authors: Yousuf Ahmed
Meijuan Tian
Yong Gao
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: AIDS Research and Therapy / Issue 1/2017
Electronic ISSN: 1742-6405
DOI: https://doi.org/10.1186/s12981-017-0178-3

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