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Published in: Immunity & Ageing 1/2018

Open Access 01-12-2018 | Letter to the Editor

Healthy elderly Singaporeans show no age-related humoral hyporesponsiveness nor diminished plasmablast generation in response to influenza vaccine

Authors: Xavier Camous, Lucian Visan, Crystal Tan Tze Ying, Brian Abel, Ma Shwe Zin Nyunt, Vipin Narang, Michael Poidinger, Christophe Carre, Sanie Sesay, Nabil Bosco, Nicolas Burdin, Paul Anantharajah Tambyah, Ng Tze Pin, Anis Larbi

Published in: Immunity & Ageing | Issue 1/2018

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Abstract

Improving influenza vaccine efficacy is a priority to reduce the burden of influenza-associated morbidity and mortality. By careful selection of individuals based on health we show sustained response to influenza vaccination in older adults. Sustaining health in aging could be an important player in maintaining immune responses to influenza vaccination.

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Literature
1.
go back to reference Thompson WW, Shay DK, Weintraub E, Brammer L, Bridges CB, Cox NJ, et al. Influenza-associated hospitalizations in the United States. JAMA. 2004;292(11):1333–40.CrossRef Thompson WW, Shay DK, Weintraub E, Brammer L, Bridges CB, Cox NJ, et al. Influenza-associated hospitalizations in the United States. JAMA. 2004;292(11):1333–40.CrossRef
2.
go back to reference Schanzer DL, Tam TW, Langley JM, Winchester BT. Influenza-attributable deaths, Canada 1990-1999. Epidemiol Infect. 2007;135(7):1109–16.CrossRef Schanzer DL, Tam TW, Langley JM, Winchester BT. Influenza-attributable deaths, Canada 1990-1999. Epidemiol Infect. 2007;135(7):1109–16.CrossRef
3.
go back to reference Ang LW, Lim C, Lee VJ, Ma S, Tiong WW, Ooi PL, et al. Influenza-associated hospitalizations, Singapore, 2004–2008 and 2010–2012. Emerg Infect Dis. 2014;20(10):1652–60.CrossRef Ang LW, Lim C, Lee VJ, Ma S, Tiong WW, Ooi PL, et al. Influenza-associated hospitalizations, Singapore, 2004–2008 and 2010–2012. Emerg Infect Dis. 2014;20(10):1652–60.CrossRef
4.
go back to reference WHO. Vaccines against influenza WHO position paper - November 2012. Releve epidemiologique hebdomadaire. 2012;87(47):461–76. WHO. Vaccines against influenza WHO position paper - November 2012. Releve epidemiologique hebdomadaire. 2012;87(47):461–76.
5.
go back to reference Fiore AE, Uyeki TM, Broder K, Finelli L, Euler GL, Singleton JA, et al. Prevention and control of influenza with vaccines: recommendations of the advisory committee on immunization practices (ACIP), 2010. MMWR Recomm Rep. 2010;59(RR-8):1–62.PubMed Fiore AE, Uyeki TM, Broder K, Finelli L, Euler GL, Singleton JA, et al. Prevention and control of influenza with vaccines: recommendations of the advisory committee on immunization practices (ACIP), 2010. MMWR Recomm Rep. 2010;59(RR-8):1–62.PubMed
6.
go back to reference Beyer WE, McElhaney J, Smith DJ, Monto AS. Nguyen-Van-tam JS, Osterhaus AD. Cochrane re-arranged: support for policies to vaccinate elderly people against influenza. Vaccine. 2013;31(50):6030–3.CrossRef Beyer WE, McElhaney J, Smith DJ, Monto AS. Nguyen-Van-tam JS, Osterhaus AD. Cochrane re-arranged: support for policies to vaccinate elderly people against influenza. Vaccine. 2013;31(50):6030–3.CrossRef
7.
go back to reference DiazGranados CA, Dunning AJ, Kimmel M, Kirby D, Treanor J, Collins A, et al. Efficacy of high-dose versus standard-dose influenza vaccine in older adults. N Engl J Med. 2014;371(7):635–45.CrossRef DiazGranados CA, Dunning AJ, Kimmel M, Kirby D, Treanor J, Collins A, et al. Efficacy of high-dose versus standard-dose influenza vaccine in older adults. N Engl J Med. 2014;371(7):635–45.CrossRef
8.
go back to reference Haq K, JE ME. Immunosenescence: Influenza vaccination and the elderly. Curr Opin Immunol. 2014;29:38–42.CrossRef Haq K, JE ME. Immunosenescence: Influenza vaccination and the elderly. Curr Opin Immunol. 2014;29:38–42.CrossRef
9.
go back to reference Franceschi C, Capri M, Monti D, Giunta S, Olivieri F, Sevini F, et al. Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev. 2007;128(1):92–105.CrossRef Franceschi C, Capri M, Monti D, Giunta S, Olivieri F, Sevini F, et al. Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev. 2007;128(1):92–105.CrossRef
10.
go back to reference Solana R, Tarazona R, Gayoso I, Lesur O, Dupuis G, Fulop T. Innate immunosenescence: effect of aging on cells and receptors of the innate immune system in humans. Semin Immunol. 2012;24(5):331–41.CrossRef Solana R, Tarazona R, Gayoso I, Lesur O, Dupuis G, Fulop T. Innate immunosenescence: effect of aging on cells and receptors of the innate immune system in humans. Semin Immunol. 2012;24(5):331–41.CrossRef
11.
go back to reference Mosterin Hopping A, McElhaney J, Fonville JM, Powers DC, Beyer WE, Smith DJ. The confounded effects of age and exposure history in response to influenza vaccination. Vaccine. 2016;34(4):540–6.CrossRef Mosterin Hopping A, McElhaney J, Fonville JM, Powers DC, Beyer WE, Smith DJ. The confounded effects of age and exposure history in response to influenza vaccination. Vaccine. 2016;34(4):540–6.CrossRef
12.
go back to reference Belongia EA, Skowronski DM, McLean HQ, Chambers C, Sundaram ME, De Serres G. Repeated annual influenza vaccination and vaccine effectiveness: review of evidence. Expert Rev Vaccines. 2017;16(7):1–14.CrossRef Belongia EA, Skowronski DM, McLean HQ, Chambers C, Sundaram ME, De Serres G. Repeated annual influenza vaccination and vaccine effectiveness: review of evidence. Expert Rev Vaccines. 2017;16(7):1–14.CrossRef
13.
go back to reference Pulendran B, Li S, Nakaya HI. Systems vaccinology. Immunity. 2010;33(4):516–29.CrossRef Pulendran B, Li S, Nakaya HI. Systems vaccinology. Immunity. 2010;33(4):516–29.CrossRef
14.
go back to reference Nakaya HI, Hagan T, Duraisingham SS, Lee EK, Kwissa M, Rouphael N, et al. Systems analysis of immunity to influenza vaccination across multiple years and in diverse populations reveals shared molecular signatures. Immunity. 2015;43(6):1186–98.CrossRef Nakaya HI, Hagan T, Duraisingham SS, Lee EK, Kwissa M, Rouphael N, et al. Systems analysis of immunity to influenza vaccination across multiple years and in diverse populations reveals shared molecular signatures. Immunity. 2015;43(6):1186–98.CrossRef
15.
go back to reference Ligthart GJ, Corberand JX, Fournier C, Galanaud P, Hijmans W, Kennes B, et al. Admission criteria for immunogerontological studies in man: the SENIEUR protocol. Mech Ageing Dev. 1984;28(1):47–55.CrossRef Ligthart GJ, Corberand JX, Fournier C, Galanaud P, Hijmans W, Kennes B, et al. Admission criteria for immunogerontological studies in man: the SENIEUR protocol. Mech Ageing Dev. 1984;28(1):47–55.CrossRef
16.
go back to reference Feng L, Chong MS, Lim WS, Lee TS, Collinson SL, Yap P, et al. Metabolic syndrome and amnestic mild cognitive impairment: Singapore longitudinal ageing Study-2 findings. J Alzheimers Dis. 2013;34(3):649–57.CrossRef Feng L, Chong MS, Lim WS, Lee TS, Collinson SL, Yap P, et al. Metabolic syndrome and amnestic mild cognitive impairment: Singapore longitudinal ageing Study-2 findings. J Alzheimers Dis. 2013;34(3):649–57.CrossRef
17.
go back to reference Feng L, Zin Nyunt MS, Gao Q, Feng L, Yap KB, Ng TP. Cognitive frailty and adverse health outcomes: findings from the Singapore longitudinal ageing studies (SLAS). J Am Med Dir Assoc. 2017;18(3):252–8.CrossRef Feng L, Zin Nyunt MS, Gao Q, Feng L, Yap KB, Ng TP. Cognitive frailty and adverse health outcomes: findings from the Singapore longitudinal ageing studies (SLAS). J Am Med Dir Assoc. 2017;18(3):252–8.CrossRef
18.
go back to reference Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146–56.CrossRef Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146–56.CrossRef
19.
go back to reference EMA. Guideline on Influenza Vaccines: Non-clinical and Clinical Module London, United Kingdom: 2016 Contract No.: EMA/CHMP/VWP/457259/2014. EMA. Guideline on Influenza Vaccines: Non-clinical and Clinical Module London, United Kingdom: 2016 Contract No.: EMA/CHMP/VWP/457259/2014.
20.
go back to reference FDA. Guidance for Industry: Clinical Data Needed to Support the Licensure of Seasonal Inactivated Influenza Vaccines Research CfBEa; 2007. FDA. Guidance for Industry: Clinical Data Needed to Support the Licensure of Seasonal Inactivated Influenza Vaccines Research CfBEa; 2007.
21.
go back to reference Van Epps P, Tumpey T, Pearce MB, Golding H, Higgins P, Hornick T, et al. Preexisting immunity, not frailty phenotype, predicts influenza Postvaccination titers among older veterans. Clin Vaccine Immunol. 2017;24(3):e00498–16.PubMedPubMedCentral Van Epps P, Tumpey T, Pearce MB, Golding H, Higgins P, Hornick T, et al. Preexisting immunity, not frailty phenotype, predicts influenza Postvaccination titers among older veterans. Clin Vaccine Immunol. 2017;24(3):e00498–16.PubMedPubMedCentral
22.
go back to reference Lu Y, Tan CT, Nyunt MS, Mok EW, Camous X, Kared H, et al. Inflammatory and immune markers associated with physical frailty syndrome: findings from Singapore longitudinal aging studies. Oncotarget. 2016;7(20):28783–95.CrossRef Lu Y, Tan CT, Nyunt MS, Mok EW, Camous X, Kared H, et al. Inflammatory and immune markers associated with physical frailty syndrome: findings from Singapore longitudinal aging studies. Oncotarget. 2016;7(20):28783–95.CrossRef
23.
go back to reference McElhaney JE, Garneau H, Camous X, Dupuis G, Pawelec G, Baehl S, et al. Predictors of the antibody response to influenza vaccination in older adults with type 2 diabetes. BMJ Open Diabetes Res Care. 2015;3(1):e000140.CrossRef McElhaney JE, Garneau H, Camous X, Dupuis G, Pawelec G, Baehl S, et al. Predictors of the antibody response to influenza vaccination in older adults with type 2 diabetes. BMJ Open Diabetes Res Care. 2015;3(1):e000140.CrossRef
24.
go back to reference McLean HQ, Chow BD, VanWormer JJ, King JP, Belongia EA. Effect of statin use on influenza vaccine effectiveness. J Infect Dis. 2016;214(8):1150–8.CrossRef McLean HQ, Chow BD, VanWormer JJ, King JP, Belongia EA. Effect of statin use on influenza vaccine effectiveness. J Infect Dis. 2016;214(8):1150–8.CrossRef
25.
go back to reference Ridda I, Macintyre CR, Lindley R, Gao Z, Sullivan JS, Yuan FF, et al. Immunological responses to pneumococcal vaccine in frail older people. Vaccine. 2009;27(10):1628–36.CrossRef Ridda I, Macintyre CR, Lindley R, Gao Z, Sullivan JS, Yuan FF, et al. Immunological responses to pneumococcal vaccine in frail older people. Vaccine. 2009;27(10):1628–36.CrossRef
26.
go back to reference Talbot HK, Nian H, Chen Q, Zhu Y, Edwards KM, Griffin MR. Evaluating the case-positive, control test-negative study design for influenza vaccine effectiveness for the frailty bias. Vaccine. 2016;34(15):1806–9.CrossRef Talbot HK, Nian H, Chen Q, Zhu Y, Edwards KM, Griffin MR. Evaluating the case-positive, control test-negative study design for influenza vaccine effectiveness for the frailty bias. Vaccine. 2016;34(15):1806–9.CrossRef
27.
go back to reference Aspinall R, Lang PO. Vaccination choices for older people, looking beyond age specific approaches. Expert Rev Vaccines. 2018;17(1):23–30.PubMed Aspinall R, Lang PO. Vaccination choices for older people, looking beyond age specific approaches. Expert Rev Vaccines. 2018;17(1):23–30.PubMed
Metadata
Title
Healthy elderly Singaporeans show no age-related humoral hyporesponsiveness nor diminished plasmablast generation in response to influenza vaccine
Authors
Xavier Camous
Lucian Visan
Crystal Tan Tze Ying
Brian Abel
Ma Shwe Zin Nyunt
Vipin Narang
Michael Poidinger
Christophe Carre
Sanie Sesay
Nabil Bosco
Nicolas Burdin
Paul Anantharajah Tambyah
Ng Tze Pin
Anis Larbi
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Immunity & Ageing / Issue 1/2018
Electronic ISSN: 1742-4933
DOI
https://doi.org/10.1186/s12979-018-0137-4

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