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Journal of Neuroinflammation
Published in: Journal of Neuroinflammation 1/2017

Open Access 01-12-2017 | Research

Functional changes in hippocampal synaptic signaling in offspring survivors of a mouse model of intrauterine inflammation

Authors: Melissa H. Kelley, Wendy W. Wu, Jun Lei, Michael McLane, Han Xie, Kyle D. Hart, Leonardo Pereira, Irina Burd, James Maylie

Published in: Journal of Neuroinflammation | Issue 1/2017

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Abstract

Background

Recent evidence suggests that exposure to intrauterine inflammation causes acute fetal brain injury and is linked to a spectrum of neurobehavioral disorders. In a rodent model of intrauterine inflammation induced by lipopolysaccharide (LPS) exposure in utero, activated microglia can be detected in the hippocampus of offspring survivors, as late as 60 days postnatal (DPN). Given that the hippocampus is important for learning and memory, these results suggest that in utero inflammation underlies long-term cognitive deficits observed in children/survivors.

Methods

An established mouse model of LPS-induced intrauterine inflammation was used to study hippocampal function from offspring at 44–59 DPN. Microgliosis was examined at 45 DPN. Extracellular field recordings of synaptic transmission were performed on acute hippocampal slices.

Results

LPS offspring mice displayed persistent microglial activation and increased CA3–CA1 excitatory synaptic strength, which can be explained in part by an increase in the probability of glutamate release, and reduced long-term synaptic potentiation compared to control mice.

Conclusions

These results offer a mechanistic explanation for the cognitive and behavioral deficits observed in survivors of preterm birth caused by intrauterine inflammation.
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Metadata
Title
Functional changes in hippocampal synaptic signaling in offspring survivors of a mouse model of intrauterine inflammation
Authors
Melissa H. Kelley
Wendy W. Wu
Jun Lei
Michael McLane
Han Xie
Kyle D. Hart
Leonardo Pereira
Irina Burd
James Maylie
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Journal of Neuroinflammation / Issue 1/2017
Electronic ISSN: 1742-2094
DOI
https://doi.org/10.1186/s12974-017-0951-1

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