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Open Access 01-12-2017 | Research

Obesity and neuroinflammatory phenotype in mice lacking endothelial megalin

Authors: Fernando Bartolome, Desiree Antequera, Eva Tavares, Consuelo Pascual, Rosario Maldonado, Antoni Camins, Eva Carro

Published in: Journal of Neuroinflammation | Issue 1/2017

Abstract

Background

The multiligand receptor megalin controls the brain uptake of a number of ligands, including insulin and leptin. Despite the role of megalin in the transport of these metabolically relevant hormones, the role of megalin at the blood–brain-barrier (BBB) has not yet been explored in the context of metabolic regulation.

Methods

Here we investigate the role of brain endothelial megalin in energy metabolism and leptin signaling using an endothelial cell-specific megalin deficient (EMD) mouse model.

Results

We found megalin is important to protect mice from developing obesity and metabolic syndrome when mice are fed a normal chow diet. EMD mice developed neuroinflammation, by triggering several pro-inflammatory cytokines, displayed reduced neurogenesis and mitochondrial deregulation.

Conclusions

These results implicate brain endothelial megalin expression in obesity-related metabolic changes through the leptin signaling pathway proposing a potential link between obesity and neurodegeneration.

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Title: Obesity and neuroinflammatory phenotype in mice lacking endothelial megalin
Authors: Fernando Bartolome
Desiree Antequera
Eva Tavares
Consuelo Pascual
Rosario Maldonado
Antoni Camins
Eva Carro
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: Journal of Neuroinflammation / Issue 1/2017
Electronic ISSN: 1742-2094
DOI: https://doi.org/10.1186/s12974-017-0800-2

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Obesity and neuroinflammatory phenotype in mice lacking endothelial megalin

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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