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Journal of Neuroinflammation
Published in: Journal of Neuroinflammation 1/2015

Open Access 01-12-2015 | Short report

Deep brain stimulation induces antiapoptotic and anti-inflammatory effects in epileptic rats

Authors: Beatriz O. Amorim, Luciene Covolan, Elenn Ferreira, José Geraldo Brito, Diego P. Nunes, David G. de Morais, José N. Nobrega, Antonio M. Rodrigues, Antonio Carlos G. deAlmeida, Clement Hamani

Published in: Journal of Neuroinflammation | Issue 1/2015

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Abstract

Background

Status epilepticus (SE) is a severe condition that may lead to hippocampal cell loss and epileptogenesis. Some of the mechanisms associated with SE-induced cell death are excitotoxicity, neuroinflammation, and apoptosis.

Objective

The objective of the present study is to test the hypothesis that DBS has anti-inflammatory and antiapoptotic effects when applied during SE.

Methods

Rats undergoing pilocarpine-induced SE were treated with anterior thalamic nucleus (AN) deep brain stimulation (DBS). Inflammatory changes and caspase 3 activity were measured within 1 week of treatment.

Results

In pilocarpine-treated rats, DBS countered the significant increase in hippocampal caspase 3 activity and interleukin-6 (IL-6) levels that follows SE but had no effect on tumor necrosis factor α (TNFα).

Conclusions

DBS has anti-inflammatory and antiapoptotic effects when given to animals undergoing status.
Appendix
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Metadata
Title
Deep brain stimulation induces antiapoptotic and anti-inflammatory effects in epileptic rats
Authors
Beatriz O. Amorim
Luciene Covolan
Elenn Ferreira
José Geraldo Brito
Diego P. Nunes
David G. de Morais
José N. Nobrega
Antonio M. Rodrigues
Antonio Carlos G. deAlmeida
Clement Hamani
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Journal of Neuroinflammation / Issue 1/2015
Electronic ISSN: 1742-2094
DOI
https://doi.org/10.1186/s12974-015-0384-7

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