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Published in: Pediatric Rheumatology 1/2017

Open Access 01-12-2017 | Research article

Ultrasound-guided steroid tendon sheath injections in juvenile idiopathic arthritis: a 10-year single-center retrospective study

Authors: Shannon E. Peters, Ronald M. Laxer, Bairbre L. Connolly, Dimitri A. Parra

Published in: Pediatric Rheumatology | Issue 1/2017

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Abstract

Background

The aims of this study were to: (a) Identify tendon sheaths most commonly treated with steroid injections in a pediatric patient population with Juvenile Idiopathic Arthritis (JIA); (b) Describe technical aspects of the procedure; (c) Characterize sonographic appearance of tenosynovitis in JIA; (d) Assess agreement between clinical request and sites injected.

Methods

This was a 10 year single-center retrospective study (May 2006-April 2016) of patients with JIA referred by Rheumatology for ultrasound-guided tendon sheath injections. Patient demographics, clinical referral information, sonographic appearance of the tendon sheaths and technical aspects of the procedure were analyzed.

Results

There were 308 procedures of 244 patients (75% female, mean age 9.6 years) who underwent a total of 926 tendon sheath injections. Ankle tendons were most commonly injected (84.9%), specifically the tendon sheaths of tibialis posterior (22.3%), peroneus longus (20%) and brevis (19.7%). The majority of treated sites (91.9%) showed peritendinous fluid and sheath thickening on ultrasound. There were 2 minor intra-procedure complications without sequelae. A good agreement between clinical request and sites injected was observed.

Conclusions

Ultrasound-guided tendon sheath injections with steroids are used frequently to treat patients with JIA. It is a safe intervention with a high technical success rate. The ankle region, specifically the medial compartment, is the site most commonly injected in this group of patients. The most common sonographic finding is peritendinous fluid and sheath thickening. These findings might assist clinicians and radiologists to characterize and more effectively manage tenosynovitis in patients with JIA.
Literature
1.
2.
go back to reference Hashkes PJ, Laxer RM. Medical treatment of juvenile idiopathic arthritis. JAMA. 2005;294:1671–84.CrossRefPubMed Hashkes PJ, Laxer RM. Medical treatment of juvenile idiopathic arthritis. JAMA. 2005;294:1671–84.CrossRefPubMed
3.
go back to reference Selvaag AM, Flato B, Dale K, Lien G, Vinje O, Smerdel-Ramoya A, Forre O. Radiographic and clinical outcome in early juvenile rheumatoid arthritis and juvenile spondyloarthropathy: a 3-year prospective study. J Rheumatol. 2006;33:1382–91.PubMed Selvaag AM, Flato B, Dale K, Lien G, Vinje O, Smerdel-Ramoya A, Forre O. Radiographic and clinical outcome in early juvenile rheumatoid arthritis and juvenile spondyloarthropathy: a 3-year prospective study. J Rheumatol. 2006;33:1382–91.PubMed
4.
go back to reference Kaibara N, Yamada H, Shuto T, Nakashima Y, Okazaki K, Miyahara H, Esaki Y, Hirata G, Iwamoto Y. Comparative histopathological analysis between tenosynovitis and joint synovitis in rheumatoid arthritis. Histopathology. 2008;52:856–64.CrossRefPubMed Kaibara N, Yamada H, Shuto T, Nakashima Y, Okazaki K, Miyahara H, Esaki Y, Hirata G, Iwamoto Y. Comparative histopathological analysis between tenosynovitis and joint synovitis in rheumatoid arthritis. Histopathology. 2008;52:856–64.CrossRefPubMed
5.
go back to reference Rooney ME, McAllister C, Burns JF. Ankle disease in juvenile idiopathic arthritis: ultrasound findings in clinically swollen ankles. J Rheumatol. 2009;36:1725–9.CrossRefPubMed Rooney ME, McAllister C, Burns JF. Ankle disease in juvenile idiopathic arthritis: ultrasound findings in clinically swollen ankles. J Rheumatol. 2009;36:1725–9.CrossRefPubMed
6.
go back to reference Javadi S, Kan JH, Orth RC, DeGuzman M. Wrist and ankle MRI of patients with juvenile idiopathic arthritis: identification of unsuspected multicompartmental tenosynovitis and arthritis. AJR Am J Roentgenol. 2014;202:413–7.CrossRefPubMed Javadi S, Kan JH, Orth RC, DeGuzman M. Wrist and ankle MRI of patients with juvenile idiopathic arthritis: identification of unsuspected multicompartmental tenosynovitis and arthritis. AJR Am J Roentgenol. 2014;202:413–7.CrossRefPubMed
7.
go back to reference Grassi W, Filippucci E, Busilacchi P. Musculoskeletal ultrasound. Best Pract Res Clin Rheumatol. 2004;18:813–26.CrossRefPubMed Grassi W, Filippucci E, Busilacchi P. Musculoskeletal ultrasound. Best Pract Res Clin Rheumatol. 2004;18:813–26.CrossRefPubMed
8.
go back to reference Wakefield RJ, Balint PV, Szkudlarek M, Filippucci E, Backhaus M, D’Agostino MA, Sanchez EN, Iagnocco A, Schmidt WA, Bruyn GA, et al. Musculoskeletal ultrasound including definitions for ultrasonographic pathology. J Rheumatol. 2005;32:2485–7.PubMed Wakefield RJ, Balint PV, Szkudlarek M, Filippucci E, Backhaus M, D’Agostino MA, Sanchez EN, Iagnocco A, Schmidt WA, Bruyn GA, et al. Musculoskeletal ultrasound including definitions for ultrasonographic pathology. J Rheumatol. 2005;32:2485–7.PubMed
9.
go back to reference Gutierrez M, Di Matteo A, Rosemffet M, Cazenave T, Rodriguez-Gil G, Diaz CH, Rios LV, Zamora N, Guzman Mdel C, Carrillo I, et al. Short-term efficacy to conventional blind injection versus ultrasound-guided injection of local corticosteroids in tenosynovitis in patients with inflammatory chronic arthritis: A randomized comparative study. Joint Bone Spine. 2016;83:161–6.CrossRefPubMed Gutierrez M, Di Matteo A, Rosemffet M, Cazenave T, Rodriguez-Gil G, Diaz CH, Rios LV, Zamora N, Guzman Mdel C, Carrillo I, et al. Short-term efficacy to conventional blind injection versus ultrasound-guided injection of local corticosteroids in tenosynovitis in patients with inflammatory chronic arthritis: A randomized comparative study. Joint Bone Spine. 2016;83:161–6.CrossRefPubMed
10.
go back to reference Hendry GJ, Gardner-Medwin J, Steultjens MP, Woodburn J, Sturrock RD, Turner DE. Frequent discordance between clinical and musculoskeletal ultrasound examinations of foot disease in juvenile idiopathic arthritis. Arthritis Care Res (Hoboken). 2012;64:441–7.CrossRef Hendry GJ, Gardner-Medwin J, Steultjens MP, Woodburn J, Sturrock RD, Turner DE. Frequent discordance between clinical and musculoskeletal ultrasound examinations of foot disease in juvenile idiopathic arthritis. Arthritis Care Res (Hoboken). 2012;64:441–7.CrossRef
11.
go back to reference Pascoli L, Wright S, McAllister C, Rooney M. Prospective evaluation of clinical and ultrasound findings in ankle disease in juvenile idiopathic arthritis: importance of ankle ultrasound. J Rheumatol. 2010;37:2409–14.CrossRefPubMed Pascoli L, Wright S, McAllister C, Rooney M. Prospective evaluation of clinical and ultrasound findings in ankle disease in juvenile idiopathic arthritis: importance of ankle ultrasound. J Rheumatol. 2010;37:2409–14.CrossRefPubMed
12.
go back to reference Omary RA, Bettmann MA, Cardella JF, Bakal CW, Schwartzberg MS, Sacks D, Rholl KS, Meranze SG, Lewis CA. Quality improvement guidelines for the reporting and archiving of interventional radiology procedures. J Vasc Interv Radiol. 2003;14:S293–295.CrossRefPubMed Omary RA, Bettmann MA, Cardella JF, Bakal CW, Schwartzberg MS, Sacks D, Rholl KS, Meranze SG, Lewis CA. Quality improvement guidelines for the reporting and archiving of interventional radiology procedures. J Vasc Interv Radiol. 2003;14:S293–295.CrossRefPubMed
13.
go back to reference Young CM, Shiels 2nd WE, Coley BD, Hogan MJ, Murakami JW, Jones K, Higgins GC, Rennebohm RM. Ultrasound-guided corticosteroid injection therapy for juvenile idiopathic arthritis: 12-year care experience. Pediatr Radiol. 2012;42:1481–9.CrossRefPubMed Young CM, Shiels 2nd WE, Coley BD, Hogan MJ, Murakami JW, Jones K, Higgins GC, Rennebohm RM. Ultrasound-guided corticosteroid injection therapy for juvenile idiopathic arthritis: 12-year care experience. Pediatr Radiol. 2012;42:1481–9.CrossRefPubMed
14.
go back to reference Lambot K, Boavida P, Damasio MB, Tanturri de Horatio L, Desgranges M, Malattia C, Barbuti D, Bracaglia C, Muller LS, Elie C, et al. MRI assessment of tenosynovitis in children with juvenile idiopathic arthritis: inter- and intra-observer variability. Pediatr Radiol. 2013;43:796–802.CrossRefPubMed Lambot K, Boavida P, Damasio MB, Tanturri de Horatio L, Desgranges M, Malattia C, Barbuti D, Bracaglia C, Muller LS, Elie C, et al. MRI assessment of tenosynovitis in children with juvenile idiopathic arthritis: inter- and intra-observer variability. Pediatr Radiol. 2013;43:796–802.CrossRefPubMed
15.
go back to reference Naredo E, D’Agostino MA, Wakefield RJ, Moller I, Balint PV, Filippucci E, Iagnocco A, Karim Z, Terslev L, Bong DA, et al. Reliability of a consensus-based ultrasound score for tenosynovitis in rheumatoid arthritis. Ann Rheum Dis. 2013;72:1328–34.CrossRefPubMed Naredo E, D’Agostino MA, Wakefield RJ, Moller I, Balint PV, Filippucci E, Iagnocco A, Karim Z, Terslev L, Bong DA, et al. Reliability of a consensus-based ultrasound score for tenosynovitis in rheumatoid arthritis. Ann Rheum Dis. 2013;72:1328–34.CrossRefPubMed
16.
go back to reference Bruyn GA, Hanova P, Iagnocco A, d’Agostino MA, Moller I, Terslev L, Backhaus M, Balint PV, Filippucci E, Baudoin P, et al. Ultrasound definition of tendon damage in patients with rheumatoid arthritis. Results of a OMERACT consensus-based ultrasound score focussing on the diagnostic reliability. Ann Rheum Dis. 2014;73:1929–34.CrossRefPubMed Bruyn GA, Hanova P, Iagnocco A, d’Agostino MA, Moller I, Terslev L, Backhaus M, Balint PV, Filippucci E, Baudoin P, et al. Ultrasound definition of tendon damage in patients with rheumatoid arthritis. Results of a OMERACT consensus-based ultrasound score focussing on the diagnostic reliability. Ann Rheum Dis. 2014;73:1929–34.CrossRefPubMed
17.
go back to reference Ammitzboll-Danielsen M, Ostergaard M, Naredo E, Terslev L. Validity and sensitivity to change of the semi-quantitative OMERACT ultrasound scoring system for tenosynovitis in patients with rheumatoid arthritis. Rheumatology (Oxford). 2016;55:2156–66.CrossRef Ammitzboll-Danielsen M, Ostergaard M, Naredo E, Terslev L. Validity and sensitivity to change of the semi-quantitative OMERACT ultrasound scoring system for tenosynovitis in patients with rheumatoid arthritis. Rheumatology (Oxford). 2016;55:2156–66.CrossRef
18.
go back to reference Vlad V, Berghea F, Micu M, Varzaru L, Bojinca M, Milicescu M, Ionescu R, Naredo E. Tenosynovitis US scoring systems follow synovitis and clinical scoring systems in RA and are responsive to change after biologic therapy. Med Ultrason. 2015;17:352–60.CrossRefPubMed Vlad V, Berghea F, Micu M, Varzaru L, Bojinca M, Milicescu M, Ionescu R, Naredo E. Tenosynovitis US scoring systems follow synovitis and clinical scoring systems in RA and are responsive to change after biologic therapy. Med Ultrason. 2015;17:352–60.CrossRefPubMed
19.
go back to reference Collado P, Malattia C. Imaging in paediatric rheumatology: Is it time for imaging? Best Pract Res Clin Rheumatol. 2016;30:720–35.CrossRefPubMed Collado P, Malattia C. Imaging in paediatric rheumatology: Is it time for imaging? Best Pract Res Clin Rheumatol. 2016;30:720–35.CrossRefPubMed
20.
go back to reference Roth J, Ravagnani V, Backhaus M, Balint P, Bruns A, Bruyn GA, Collado P, De la Cruz L, Guillaume-Czitrom S, Herlin T, et al: Preliminary definitions for the sonographic features of synovitis in children. Arthritis Care Res (Hoboken) 2016. doi: 10.1002/acr.23130. Roth J, Ravagnani V, Backhaus M, Balint P, Bruns A, Bruyn GA, Collado P, De la Cruz L, Guillaume-Czitrom S, Herlin T, et al: Preliminary definitions for the sonographic features of synovitis in children. Arthritis Care Res (Hoboken) 2016. doi: 10.​1002/​acr.​23130.
Metadata
Title
Ultrasound-guided steroid tendon sheath injections in juvenile idiopathic arthritis: a 10-year single-center retrospective study
Authors
Shannon E. Peters
Ronald M. Laxer
Bairbre L. Connolly
Dimitri A. Parra
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Pediatric Rheumatology / Issue 1/2017
Electronic ISSN: 1546-0096
DOI
https://doi.org/10.1186/s12969-017-0155-3

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