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Open Access 01-12-2017 | Review

Methods for analyzing observational longitudinal prognosis studies for rheumatic diseases: a review & worked example using a clinic-based cohort of juvenile dermatomyositis patients

Authors: Lily Siok Hoon Lim, Eleanor Pullenayegum, Rahim Moineddin, Dafna D Gladman, Earl D Silverman, Brian M Feldman

Published in: Pediatric Rheumatology | Issue 1/2017

Abstract

Most outcome studies of rheumatic diseases report outcomes ascertained on a single occasion. While single assessments are sufficient for terminal or irreversible outcomes, they may not be sufficiently informative if outcomes change or fluctuate over time. Consequently, longitudinal studies that measure non-terminal outcomes repeatedly afford a better understanding of disease evolution.

Longitudinal studies require special analytic methods. Newer longitudinal analytic methods have evolved tremendously to deal with common challenges in longitudinal observational studies. In recent years, an increasing number of studies have used longitudinal design. This review aims to help readers understand and apply the findings from longitudinal studies. Using a cohort of children with juvenile dermatomyositis (JDM), we illustrate how to study evolution of disease activity in JDM using longitudinal methods.

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Title: Methods for analyzing observational longitudinal prognosis studies for rheumatic diseases: a review & worked example using a clinic-based cohort of juvenile dermatomyositis patients
Authors: Lily Siok Hoon Lim
Eleanor Pullenayegum
Rahim Moineddin
Dafna D Gladman
Earl D Silverman
Brian M Feldman
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: Pediatric Rheumatology / Issue 1/2017
Electronic ISSN: 1546-0096
DOI: https://doi.org/10.1186/s12969-017-0148-2

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Methods for analyzing observational longitudinal prognosis studies for rheumatic diseases: a review & worked example using a clinic-based cohort of juvenile dermatomyositis patients

Abstract

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

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