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Open Access 01-12-2016 | Short Report

Arterial dissection in childhood Takayasu Arteritis: not as rare as thought

Authors: Florence A. Aeschlimann, Lars Grosse-Wortmann, Susanne M. Benseler, Ronald M. Laxer, Diane Hebert, Rae S.M. Yeung

Published in: Pediatric Rheumatology | Issue 1/2016

Abstract

Background

Arterial vessel wall dissection is a rare, life-threatening and rarely described complication in childhood Takayasu Arteritis (cTA). Prevalence and risk factors for arterial dissection in cTA are unknown. We sought to study the prevalence and analyse risk factors for arterial dissection in cTA.

Findings

A single center retrospective review of all children with cTA was performed. Patients with arterial dissection at cTA diagnosis were reported in detail and compared to the remaining single center retrospective cohort of children without dissection. Disease activity was assessed by the Pediatric Vasculitis Disease Activity Score (PVAS). A total of 27 cTA patients (74 % girls) were included. Three children (11 %) presented with dissection at diagnosis of cTA. They had higher PVAS (median 21 versus 10, p = 0.26), increased neutrophils (p < 0.0001) and lower albumin levels (p = 0.05). Arterial hypertension was common in both groups: in 67 % of children with dissection and 54 % of those without.

Conclusions

Arterial dissection was more frequent in our cTA cohort than previously reported. Careful vascular imaging assessment is crucial to document this complication. High disease activity and markers of inflammation especially in combination with arterial hypertension, may be associated with the risk for vessel wall dissection in children with cTA.

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Title: Arterial dissection in childhood Takayasu Arteritis: not as rare as thought
Authors: Florence A. Aeschlimann
Lars Grosse-Wortmann
Susanne M. Benseler
Ronald M. Laxer
Diane Hebert
Rae S.M. Yeung
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: Pediatric Rheumatology / Issue 1/2016
Electronic ISSN: 1546-0096
DOI: https://doi.org/10.1186/s12969-016-0115-3

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Arterial dissection in childhood Takayasu Arteritis: not as rare as thought

Abstract

Background

Findings

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Findings

Conclusions

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