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Journal of Cardiovascular Magnetic Resonance
Published in: Journal of Cardiovascular Magnetic Resonance 1/2017

Open Access 01-12-2017 | Research

Quantification of myocardial deformation in children by cardiovascular magnetic resonance feature tracking: determination of reference values for left ventricular strain and strain rate

Authors: Florian André, Daniëlle Robbers-Visser, Astrid Helling-Bakki, Angela Föll, Andreas Voss, Hugo A. Katus, Willem A. Helbing, Sebastian J. Buss, Joachim G. Eichhorn

Published in: Journal of Cardiovascular Magnetic Resonance | Issue 1/2017

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Abstract

Background

The objective assessment of global and regional cardiac function in children has shown to be clinically relevant but is challenging to conduct. Cardiovascular magnetic resonance (CMR) has emerged as a valuable diagnostic modality especially in patients with cardiomyopathy or congenital heart disease. However, data on the normal cardiac deformation in children assessed by CMR is lacking at present. Thus, the aim of this study was to provide reference values for cardiac strain and strain rate in children and adolescents derived from CMR feature tracking (FT) measurements.

Methods

In this binational study, eighty children and adolescents (age 0.4–18.0 years, 41 male, 39 female) free from cardiac diseases from two centers underwent CMR in 1.5 T whole-body scanners in supine position. Global peak radial, circumferential and longitudinal systolic strains as well as the corresponding early peak diastolic strain rates were assessed applying FT on short axis as well as 3- and 4-chamber views of standard cine steady-state free precession images.

Results

The difference between genders yielded no significance for all assessed strains. Yet, all strains showed a significant parabolic relation to age and an even stronger one to body surface area (BSA). Therefore, BSA-specific reference values were determined using a polynomial regression model. The apical cardiac segments featured significant higher peak circumferential but lower peak radial systolic strains than the midventricular and basal segments (all p < 0.001).

Conclusions

The assessment of cardiac deformation by CMR-FT is feasible in children. This is the first CMR study providing specific reference values for FT-derived strain and strain rate in the pediatric age range.
Appendix
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Literature
1.
Marcus KA, Mavinkurve-Groothuis AM, Barends M, van Dijk A, Feuth T, de Korte C, Kapusta L. Reference values for myocardial two-dimensional strain echocardiography in a healthy pediatric and young adult cohort. J Am Soc Echocardiogr. 2011;24:625–36.CrossRefPubMed
2.
Pacileo G, Di Salvo G, Limongelli G, Miele T, Calabro R. Echocardiography in congenital heart disease: usefulness, limits and new techniques. J Cardiovasc Med (Hagerstown). 2007;8:17–22.CrossRef
3.
Ntsinjana HN, Hughes ML, Taylor AM. The Role of Cardiovascular Magnetic Resonance in Pediatric Congenital Heart Disease. J Cardiovasc Magn Reson. 2011;13:51.CrossRefPubMedPubMedCentral
4.
Fratz S, Chung T, Greil GF, Samyn MM, Taylor AM, Valsangiacomo Buechel ER, Yoo S-J, Powell AJ. Guidelines and protocols for cardiovascular magnetic resonance in children and adults with congenital heart disease: SCMR expert consensus group on congenital heart disease. J Cardiovasc Magn Reson. 2013;15:51.CrossRefPubMedPubMedCentral
5.
Buss SJ, Breuninger K, Lehrke S, Voss A, Galuschky C, Lossnitzer D, Andre F, Ehlermann P, Franke J, Taeger T, et al. Assessment of myocardial deformation with cardiac magnetic resonance strain imaging improves risk stratification in patients with dilated cardiomyopathy. Eur Heart J Cardiovasc Imaging. 2015;16:307–15.CrossRefPubMed
6.
Smith BM, Dorfman AL, Yu S, Russell MW, Agarwal PP, Ghadimi Mahani M, Lu JC. Relation of strain by feature tracking and clinical outcome in children, adolescents, and young adults with hypertrophic cardiomyopathy. Am J Cardiol. 2014;114:1275–80.CrossRefPubMed
7.
Onishi T, Saha SK, Ludwig DR, Onishi T, Marek JJ, Cavalcante JL, Schelbert EB, Schwartzman D, Gorcsan 3rd J. Feature tracking measurement of dyssynchrony from cardiovascular magnetic resonance cine acquisitions: comparison with echocardiographic speckle tracking. J Cardiovasc Magn Reson. 2013;15:95.CrossRefPubMedPubMedCentral
8.
Williams LK, Urbano-Moral JA, Rowin EJ, Jamorski M, Bruchal-Garbicz B, Carasso S, Pandian NG, Maron MS, Rakowski H. Velocity vector imaging in the measurement of left ventricular myocardial mechanics on cardiac magnetic resonance imaging: correlations with echocardiographically derived strain values. J Am Soc Echocardiogr. 2013;26:1153–62.CrossRefPubMed
9.
Hor KN, Gottliebson WM, Carson C, Wash E, Cnota J, Fleck R, Wansapura J, Klimeczek P, Al-Khalidi HR, Chung ES, et al. Comparison of magnetic resonance feature tracking for strain calculation with harmonic phase imaging analysis. JACC Cardiovasc Imaging. 2010;3:144–51.CrossRefPubMed
10.
Augustine D, Lewandowski AJ, Lazdam M, Rai A, Francis J, Myerson S, Noble A, Becher H, Neubauer S, Petersen SE, Leeson P. Global and regional left ventricular myocardial deformation measures by magnetic resonance feature tracking in healthy volunteers: comparison with tagging and relevance of gender. J Cardiovasc Magn Reson. 2013;15:8.CrossRefPubMedPubMedCentral
11.
Moody WE, Taylor RJ, Edwards NC, Chue CD, Umar F, Taylor TJ, Ferro CJ, Young AA, Townend JN, Leyva F, Steeds RP. Comparison of magnetic resonance feature tracking for systolic and diastolic strain and strain rate calculation with spatial modulation of magnetization imaging analysis. J Magn Reson Imaging. 2015;41:1000–12.CrossRefPubMed
12.
Andre F, Steen H, Matheis P, Westkott M, Breuninger K, Sander Y, Kammerer R, Galuschky C, Giannitsis E, Korosoglou G, et al. Age- and gender-related normal left ventricular deformation assessed by cardiovascular magnetic resonance feature tracking. J Cardiovasc Magn Reson. 2015;17:25.CrossRefPubMedPubMedCentral
13.
Taylor RJ, Moody WE, Umar F, Edwards NC, Taylor TJ, Stegemann B, Townend JN, Hor KN, Steeds RP, Mazur W, Leyva F. Myocardial strain measurement with feature-tracking cardiovascular magnetic resonance: normal values. Eur Heart J Cardiovasc Imaging. 2015;16:871–81.CrossRefPubMed
14.
Robbers-Visser D, Boersma E, Helbing WA. Normal biventricular function, volumes, and mass in children aged 8 to 17 years. J Magn Reson Imaging. 2009;29:552–9.CrossRefPubMed
15.
Mosteller RD. Simplified calculation of body-surface area. N Engl J Med. 1987;317:1098.PubMed
16.
Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, Pennell DJ, Rumberger JA, Ryan T, Verani MS, et al. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation. 2002;105:539–42.CrossRefPubMed
17.
Bussadori C, Moreo A, Di Donato M, De Chiara B, Negura D, Dall’Aglio E, Lobiati E, Chessa M, Arcidiacono C, Dua JS, et al. A new 2D-based method for myocardial velocity strain and strain rate quantification in a normal adult and paediatric population: assessment of reference values. Cardiovasc Ultrasound. 2009;7:8.CrossRefPubMedPubMedCentral
18.
Lorch SM, Ludomirsky A, Singh GK. Maturational and growth-related changes in left ventricular longitudinal strain and strain rate measured by two-dimensional speckle tracking echocardiography in healthy pediatric population. J Am Soc Echocardiogr. 2008;21:1207–15.CrossRefPubMed
19.
Poterucha JT, Kutty S, Lindquist RK, Li L, Eidem BW. Changes in left ventricular longitudinal strain with anthracycline chemotherapy in adolescents precede subsequent decreased left ventricular ejection fraction. J Am Soc Echocardiogr. 2012;25:733–40.CrossRefPubMed
20.
Sims A, Frank L, Cross R, Clauss S, Dimock D, Purdy J, Mikhail I, Hazra R, Hadigan C, Sable C. Abnormal cardiac strain in children and young adults with HIV acquired in early life. J Am Soc Echocardiogr. 2012;25:741–8.CrossRefPubMedPubMedCentral
21.
22.
Schuster A, Morton G, Hussain ST, Jogiya R, Kutty S, Asrress KN, Makowski MR, Bigalke B, Perera D, Beerbaum P, Nagel E. The intra-observer reproducibility of cardiovascular magnetic resonance myocardial feature tracking strain assessment is independent of field strength. Eur J Radiol. 2013;82:296–301.CrossRefPubMed
23.
Burke GL, Arcilla RA, Culpepper WS, Webber LS, Chiang YK, Berenson GS. Blood pressure and echocardiographic measures in children: the Bogalusa Heart Study. Circulation. 1987;75:106–14.CrossRefPubMed
24.
Milicevic G, Narancic NS, Steiner R, Rudan P. Increase in cardiac contractility during puberty. Coll Antropol. 2003;27:335–41.PubMed
25.
26.
Parks RJ, Howlett SE. Sex differences in mechanisms of cardiac excitation–contraction coupling. Pflugers Arch - Eur J Physiol. 2013;465:747–63.CrossRef
27.
Kampmann C, Wiethoff CM, Wenzel A, Stolz G, Betancor M, Wippermann CF, Huth RG, Habermehl P, Knuf M, Emschermann T, Stopfkuchen H. Normal values of M mode echocardiographic measurements of more than 2000 healthy infants and children in central Europe. Heart. 2000;83:667–72.CrossRefPubMedPubMedCentral
28.
Lam TK, Leung DT. More on simplified calculation of body-surface area. N Engl J Med. 1988;318:1130.PubMed
29.
El Edelbi R, Lindemalm S, Eksborg S. Estimation of body surface area in various childhood ages--validation of the Mosteller formula. Acta Paediatr. 2012;101:540–4.CrossRefPubMed
30.
31.
Jashari H, Rydberg A, Ibrahimi P, Bajraktari G, Kryeziu L, Jashari F, Henein MY. Normal ranges of left ventricular strain in children: a meta-analysis. Cardiovasc Ultrasound. 2015;13:37.CrossRefPubMedPubMedCentral
32.
Yingchoncharoen T, Agarwal S, Popovic ZB, Marwick TH. Normal ranges of left ventricular strain: a meta-analysis. J Am Soc Echocardiogr. 2013;26:185–91.CrossRefPubMed
33.
Venkatesh BA, Donekal S, Yoneyama K, Wu C, Fernandes VR, Rosen BD, Shehata ML, McClelland R, Bluemke DA, Lima JA. Regional myocardial functional patterns: Quantitative tagged magnetic resonance imaging in an adult population free of cardiovascular risk factors: The multi-ethnic study of atherosclerosis (MESA). J Magn Reson Imaging. 2015;42:153–9.CrossRefPubMed
34.
Hsiao J-F, Koshino Y, Bonnichsen CR, Yu Y, Miller FA, Pellikka PA, Cooper LT, Villarraga HR. Speckle tracking echocardiography in acute myocarditis. Int J Cardiovasc Imaging. 2012;29:275–84.CrossRefPubMed
35.
Andre F, Stock FT, Riffel J, Giannitsis E, Steen H, Scharhag J, Katus HA, Buss SJ. Incremental value of cardiac deformation analysis in acute myocarditis: a cardiovascular magnetic resonance imaging study. Int J Cardiovasc Imaging. 2016;32:1093–101.CrossRefPubMed
Metadata
Title
Quantification of myocardial deformation in children by cardiovascular magnetic resonance feature tracking: determination of reference values for left ventricular strain and strain rate
Authors
Florian André
Daniëlle Robbers-Visser
Astrid Helling-Bakki
Angela Föll
Andreas Voss
Hugo A. Katus
Willem A. Helbing
Sebastian J. Buss
Joachim G. Eichhorn
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Journal of Cardiovascular Magnetic Resonance / Issue 1/2017
Electronic ISSN: 1532-429X
DOI
https://doi.org/10.1186/s12968-016-0310-x

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