Published in:
Open Access
01-12-2021 | Letter to the Editor
Analysis of microbial differences in amniotic fluid between advanced and normal age pregnant women
Authors:
Ya Wang, Chunyu Luo, Yiwei Cheng, Li Li, Dong Liang, Ping Hu, Zhengfeng Xu
Published in:
Journal of Translational Medicine
|
Issue 1/2021
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Excerpt
Amniotic fluid (AF) has been considered sterile for nearly a century because no microorganisms were identified by traditional culture methods [
1]. However, this opinion paradigm has been challenged by recent studies based on culture-independent sequencing techniques [
2‐
4] and AF proteomics [
5]. Recently, a conclusion that no microorganisms were present in the mid-trimester AF of healthy pregnancies was reached using culture-independent sequencing techniques [
6] and seemed to settle the argument [
7]. However, it could not explain why non-human proteins were identified in normal human AF supernatants [
8] and why microbial exposure primes fetal immune cells in fetal tissues during fetal development [
9]. …
