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Open Access 01-12-2018 | Research

Influence of FTO rs9939609 and Mediterranean diet on body composition and weight loss: a randomized clinical trial

Authors: Laura Di Renzo, Giorgia Cioccoloni, Simone Falco, Ludovico Abenavoli, Alessandra Moia, Paola Sinibaldi Salimei, Antonino De Lorenzo

Published in: Journal of Translational Medicine | Issue 1/2018

Abstract

Background

The Mediterranean diet (MeD) plays a key role in the prevention of obesity. Among the genes involved in obesity, the Fat mass and obesity-associated gene (FTO) is one of the most known, but its interaction with MeD remained uncertain so far.

Methods

We carried out a study on a sample of 188 Italian subjects, analyzing their FTO rs9939609 alleles, and the difference in body composition between the baseline and a 4-weeks nutritional intervention. The sample was divided into two groups: the control group of 49 subjects, and the MeD group of 139 subjects.

Results

We found significant relations between MeD and both variation of total body fat (ΔTBFat) (p = 0.00) and gynoid body fat (p = 0.04). ∆TBFat (kg) demonstrated to have a significant relation with the interaction diet-gene (p = 0.04), whereas FTO was associated with the variation of total body water (p = 0.02).

Conclusions

MeD demonstrated to be a good nutritional treatment to reduce the body fat mass, whereas data about FTO remain uncertain. Confirming or rejecting the hypothesis of FTO and its influence on body tissues during nutritional treatments is fundamental to decide whether its effect has to be taken into consideration during both development of dietetic plans and patients monitoring.

Trial Registration ClinicalTrials.gov Id: NCT01890070. Registered 01 July 2013, https://clinicaltrials.gov/ct2/show/NCT01890070

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Title: Influence of FTO rs9939609 and Mediterranean diet on body composition and weight loss: a randomized clinical trial
Authors: Laura Di Renzo
Giorgia Cioccoloni
Simone Falco
Ludovico Abenavoli
Alessandra Moia
Paola Sinibaldi Salimei
Antonino De Lorenzo
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: Journal of Translational Medicine / Issue 1/2018
Electronic ISSN: 1479-5876
DOI: https://doi.org/10.1186/s12967-018-1680-7

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Influence of FTO rs9939609 and Mediterranean diet on body composition and weight loss: a randomized clinical trial

Abstract

Background

Methods

Results

Conclusions

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Abstract

Background

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Conclusions

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