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Journal of Translational Medicine
Published in: Journal of Translational Medicine 1/2017

Open Access 01-12-2017 | Review

The various aspects of genetic and epigenetic toxicology: testing methods and clinical applications

Authors: Ning Ren, Manar Atyah, Wan-Yong Chen, Chen-Hao Zhou

Published in: Journal of Translational Medicine | Issue 1/2017

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Abstract

Genotoxicity refers to the ability of harmful substances to damage genetic information in cells. Being exposed to chemical and biological agents can result in genomic instabilities and/or epigenetic alterations, which translate into a variety of diseases, cancer included. This concise review discusses, from both a genetic and epigenetic point of view, the current detection methods of different agents’ genotoxicity, along with their basic and clinical relation to human cancer, chemotherapy, germ cells and stem cells.
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Metadata
Title
The various aspects of genetic and epigenetic toxicology: testing methods and clinical applications
Authors
Ning Ren
Manar Atyah
Wan-Yong Chen
Chen-Hao Zhou
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Journal of Translational Medicine / Issue 1/2017
Electronic ISSN: 1479-5876
DOI
https://doi.org/10.1186/s12967-017-1218-4

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