Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Journal of Translational Medicine
Published in: Journal of Translational Medicine 1/2016

Open Access 01-12-2016 | Review

Recent advances in bioprinting techniques: approaches, applications and future prospects

Authors: Jipeng Li, Mingjiao Chen, Xianqun Fan, Huifang Zhou

Published in: Journal of Translational Medicine | Issue 1/2016

Login to get access

Abstract

Bioprinting technology shows potential in tissue engineering for the fabrication of scaffolds, cells, tissues and organs reproducibly and with high accuracy. Bioprinting technologies are mainly divided into three categories, inkjet-based bioprinting, pressure-assisted bioprinting and laser-assisted bioprinting, based on their underlying printing principles. These various printing technologies have their advantages and limitations. Bioprinting utilizes biomaterials, cells or cell factors as a “bioink” to fabricate prospective tissue structures. Biomaterial parameters such as biocompatibility, cell viability and the cellular microenvironment strongly influence the printed product. Various printing technologies have been investigated, and great progress has been made in printing various types of tissue, including vasculature, heart, bone, cartilage, skin and liver. This review introduces basic principles and key aspects of some frequently used printing technologies. We focus on recent advances in three-dimensional printing applications, current challenges and future directions.
Literature
1.
Huang JMY, Millis JM. Government policy and organ transplantation in China. Lancet. 2008;372:1937–8.PubMedCrossRef
2.
Zhang Q, Johnson JA, Dunne LW, Chen Y, Iyyanki T, Wu Y, Chang EI, Branch-Brooks CD, Robb GL, Butler CE. Decellularized skin/adipose tissue flap matrix for engineering vascularized composite soft tissue flaps. Acta Biomater. 2016;35:166–84.PubMedCrossRef
3.
Futrega K, Palmer JS, Kinney M, Lott WB, Ungrin MD, Zandstra PW, Doran MR. The microwell-mesh: a novel device and protocol for the high throughput manufacturing of cartilage microtissues. Biomaterials. 2015;62:1–12.PubMedCrossRef
4.
Shamaz BH, Anitha A, Vijayamohan M, Kuttappan S, Nair S, Nair MB. Relevance of fiber integrated gelatin-nanohydroxyapatite composite scaffold for bone tissue regeneration. Nanotechnology. 2015;26:405101.PubMedCrossRef
5.
Lee CH, Lee FY, Tarafder S, Kao K, Jun Y, Yang G, Mao JJ. Harnessing endogenous stem/progenitor cells for tendon regeneration. J Clin Invest. 2015;125:2690–701.PubMedPubMedCentralCrossRef
6.
Thankam FG, Muthu J. Alginate-polyester comacromer based hydrogels as physiochemically and biologically favorable entities for cardiac tissue engineering. J Colloid Interface Sci. 2015;457:52–61.PubMedCrossRef
7.
Rouwkema J, Rivron NC, van Blitterswijk CA. Vascularization in tissue engineering. Trends Biotechnol. 2008;26:434–41.PubMedCrossRef
8.
Jones AC, Arns CH, Hutmacher DW, Milthorpe BK, Sheppard AP, Knackstedt MA. The correlation of pore morphology, interconnectivity and physical properties of 3D ceramic scaffolds with bone ingrowth. Biomaterials. 2009;30:1440–51.PubMedCrossRef
9.
Hollister SJ, Maddox RD, Taboas JM. Optimal design and fabrication of scaffolds to mimic tissue properties and satisfy biological constraints. Biomaterials. 2002;23:4095–103.PubMedCrossRef
10.
Lee J, Cuddihy MJ, Kotov NA. Three-dimensional cell culture matrices: state of the art. Tissue Eng Part B Rev. 2008;14:61–86.PubMedCrossRef
11.
Leong KF, Chua CK, Sudarmadji N, Yeong WY. Engineering functionally graded tissue engineering scaffolds. J Mech Behav Biomed Mater. 2008;1:140–52.PubMedCrossRef
12.
Zong X, Bien H, Chung CY, Yin L, Fang D, Hsiao BS, Chu B, Entcheva E. Electrospun fine-textured scaffolds for heart tissue constructs. Biomaterials. 2005;26:5330–8.PubMedCrossRef
13.
Moroni L, de Wijn JR, van Blitterswijk CA. 3D fiber-deposited scaffolds for tissue engineering: influence of pores geometry and architecture on dynamic mechanical properties. Biomaterials. 2006;27:974–85.PubMedCrossRef
14.
15.
Powers MK, Lee BR, Silberstein J. Three-dimensional printing of surgical anatomy. Curr Opin Urol. 2016;26:283–8.PubMedCrossRef
16.
Cui X, Breitenkamp K, Lotz M, D’Lima D. Synergistic action of fibroblast growth factor-2 and transforming growth factor-beta1 enhances bioprinted human neocartilage formation. Biotechnol Bioeng. 2012;109:2357–68.PubMedPubMedCentralCrossRef
17.
Poldervaart MT, Wang H, van der Stok J, Weinans H, Leeuwenburgh SC, Oner FC, Dhert WJ, Alblas J. Sustained release of BMP-2 in bioprinted alginate for osteogenicity in mice and rats. PLoS ONE. 2013;8:e72610.PubMedPubMedCentralCrossRef
18.
Arslan-Yildiz A, Assal RE, Chen P, Guven S, Inci F, Demirci U. Towards artificial tissue models: past, present, and future of 3D bioprinting. Biofabrication. 2016;8:014103.PubMedCrossRef
19.
Lee SY, Kim HJ, Choi D. Cell sources, liver support systems and liver tissue engineering: alternatives to liver transplantation. Int J Stem Cells. 2015;8:36–47.PubMedPubMedCentralCrossRef
20.
Boland T, Xu T, Damon B, Cui X. Application of inkjet printing to tissue engineering. Biotechnol J. 2006;1:910–7.PubMedCrossRef
21.
Cui X, Dean D, Ruggeri ZM, Boland T. Cell damage evaluation of thermal inkjet printed Chinese hamster ovary cells. Biotechnol Bioeng. 2010;106:963–9.PubMedCrossRef
22.
23.
Cui X, Boland T, D’Lima DD, Lotz MK. Thermal inkjet printing in tissue engineering and regenerative medicine. Recent Pat Drug Deliv Formul. 2012;6:149–55.PubMedPubMedCentralCrossRef
24.
25.
Nakamura M, Kobayashi A, Takagi F, Watanabe A, Hiruma Y, Ohuchi K, Iwasaki Y, Horie M, Morita I, Takatani S. Biocompatible inkjet printing technique for designed seeding of individual living cells. Tissue Eng. 2005;11:1658–66.PubMedCrossRef
26.
Saunders RE, Gough JE, Derby B. Delivery of human fibroblast cells by piezoelectric drop-on-demand inkjet printing. Biomaterials. 2008;29:193–203.PubMedCrossRef
27.
Seetharam R, Sharma SK. Purification and analysis of recombinant proteins. Biotechnology and Bioprocessing, vol 12. CRC Press; 1991.
28.
Okamoto T, Suzuki T, Yamamoto N. Microarray fabrication with covalent attachment of DNA using bubble jet technology. Nat Biotechnol. 2000;18:438–41.PubMedCrossRef
29.
Xu T, Jin J, Gregory C, Hickman JJ, Boland T. Inkjet printing of viable mammalian cells. Biomaterials. 2005;26:93–9.PubMedCrossRef
30.
Duan B, Hockaday LA, Kang KH, Butcher JT. 3D bioprinting of heterogeneous aortic valve conduits with alginate/gelatin hydrogels. J Biomed Mater Res A. 2013;101:1255–64.PubMedCrossRef
31.
Hockaday LA, Kang KH, Colangelo NW, Cheung PY, Duan B, Malone E, Wu J, Girardi LN, Bonassar LJ, Lipson H, et al. Rapid 3D printing of anatomically accurate and mechanically heterogeneous aortic valve hydrogel scaffolds. Biofabrication. 2012;4:035005.PubMedPubMedCentralCrossRef
32.
33.
Chien KB, Makridakis E, Shah RN. Three-dimensional printing of soy protein scaffolds for tissue regeneration. Tissue Eng Part C Methods. 2013;19:417–26.PubMedCrossRef
34.
Fedorovich NE, Schuurman W, Wijnberg HM, Prins HJ, van Weeren PR, Malda J, Alblas J, Dhert WJ. Biofabrication of osteochondral tissue equivalents by printing topologically defined, cell-laden hydrogel scaffolds. Tissue Eng Part C Methods. 2012;18:33–44.PubMedCrossRef
35.
Fedorovich NE, Wijnberg HM, Dhert WJ, Alblas J. Distinct tissue formation by heterogeneous printing of osteo- and endothelial progenitor cells. Tissue Eng Part A. 2011;17:2113–21.PubMedCrossRef
36.
Catros S, Fricain JC, Guillotin B, Pippenger B, Bareille R, Remy M, Lebraud E, Desbat B, Amedee J, Guillemot F. Laser-assisted bioprinting for creating on-demand patterns of human osteoprogenitor cells and nano-hydroxyapatite. Biofabrication. 2011;3:025001.PubMedCrossRef
37.
Trombetta R, Inzana J, Schwarz EM, Kates SL, Awad HA. 3D printing of calcium phosphate ceramics for bone tissue engineering and drug delivery. Ann Biomed Eng. 2016. doi:10.​1007/​s10439-016-1678-3.
38.
Guillemot F, Souquet A, Catros S, Guillotin B. Laser-assisted cell printing: principle, physical parameters versus cell fate and perspectives in tissue engineering. Nanomedicine. 2010;5:507–15.PubMedCrossRef
39.
Guillemot F, Souquet A, Catros S, Guillotin B, Lopez J, Faucon M. Highthroughput laser printing of cells and biomaterials for tissue engineering. Acta Biomater. 2010;6:2494–500.PubMedCrossRef
40.
Barron JA, Wu P, Ladouceur HD, Ringeisen BR. Biological laser printing: a novel technique for creating heterogeneous 3-dimensional cell patterns. Biomed Microdevices. 2004;6:139–47.PubMedCrossRef
41.
Ringeisen BR, Kim H, Barron JA, Krizman DB, Chrisey DB, Jackman S, Auyeung RY, Spargo BJ. Laser printing of pluripotent embryonal carcinoma cells. Tissue Eng. 2004;10:483–91.PubMedCrossRef
42.
Michael S, Sorg H, Peck CT, Koch L, Deiwick A, Chichkov B, Vogt PM, Reimers K. Tissue engineered skin substitutes created by laser-assisted bioprinting form skin-like structures in the dorsal skin fold chamber in mice. PLoS ONE. 2013;8:e57741.PubMedPubMedCentralCrossRef
43.
Serra P, Duocastella M, Fernández-Pradas JM, Morenza JL. Liquids microprinting through laser-induced forward transfer. Appl Surf Sci. 2009;255:5342–5.CrossRef
44.
Patrascioiu A, Fernández-Pradas JM, Palla-Papavlu A, Morenza JL, Serra P. Laser-generated liquid microjets: correlation between bubble dynamics and liquid ejection. Microfluidics Nanofluidics. 2014;16:55–63.CrossRef
45.
Ali M, Pages E, Ducom A, Fontaine A, Guillemot F. Controlling laser-induced jet formation for bioprinting mesenchymal stem cells with high viability and high resolution. Biofabrication. 2014;6:045001.PubMedCrossRef
46.
Melchels FP, Feijen J, Grijpma DW. A review on stereolithography and its applications in biomedical engineering. Biomaterials. 2010;31:6121–30.PubMedCrossRef
47.
Wang Z, Abdulla R, Parker B, Samanipour R, Ghosh S, Kim K. A simple and high-resolution stereolithography-based 3D bioprinting system using visible light crosslinkable bioinks. Biofabrication. 2015;7:045009.PubMedCrossRef
48.
Khatiwala C, Law R, Shepherd B, Dorfman S, Csete M. 3D cell bioprinting for regenerative medicine research and therapies. Gene Ther. 2012;7:1–19.
49.
50.
51.
Wust S, Godla ME, Muller R, Hofmann S. Tunable hydrogel composite with two-step processing in combination with innovative hardware upgrade for cell-based three-dimensional bioprinting. Acta Biomater. 2014;10:630–40.PubMedCrossRef
52.
Matsiko A, Gleeson JP, O’Brien FJ. Scaffold mean pore size influences mesenchymal stem cell chondrogenic differentiation and matrix deposition. Tissue Eng Part A. 2015;21:486–97.PubMedCrossRef
53.
Domingos M, Intranuovo F, Russo T, De Santis R, Gloria A, Ambrosio L, Ciurana J, Bartolo P. The first systematic analysis of 3D rapid prototyped poly(epsilon-caprolactone) scaffolds manufactured through BioCell printing: the effect of pore size and geometry on compressive mechanical behaviour and in vitro hMSC viability. Biofabrication. 2013;5:045004.PubMedCrossRef
54.
Lou T, Wang X, Song G, Gu Z, Yang Z. Structure and properties of PLLA/beta-TCP nanocomposite scaffolds for bone tissue engineering. J Mater Sci Mater Med. 2015;26:5366.PubMedCrossRef
55.
Nadeem D, Smith CA, Dalby MJ, Meek RM, Lin S, Li G, Su B. Three-dimensional CaP/gelatin lattice scaffolds with integrated osteoinductive surface topographies for bone tissue engineering. Biofabrication. 2015;7:015005.PubMedCrossRef
56.
Yao Q, Wei B, Guo Y, Jin C, Du X, Yan C, Yan J, Hu W, Xu Y, Zhou Z, et al. Design, construction and mechanical testing of digital 3D anatomical data-based PCL-HA bone tissue engineering scaffold. J Mater Sci Mater Med. 2015;26:5360.PubMedCrossRef
57.
Leonardi E, Ciapetti G, Baldini N, Novajra G, Verne E, Baino F, Vitale-Brovarone C. Response of human bone marrow stromal cells to a resorbable P(2)O(5)-SiO(2)-CaO-MgO-Na(2)O-K(2)O phosphate glass ceramic for tissue engineering applications. Acta Biomater. 2010;6:598–606.PubMedCrossRef
58.
59.
Hinton TJ, Jallerat Q, Palchesko RN, Park JH, Grodzicki MS, Shue HJ, Ramadan MH, Hudson AR, Feinberg AW. Three-dimensional printing of complex biological structures by freeform reversible embedding of suspended hydrogels. Sci Adv. 2015;1:e1500758.PubMedPubMedCentralCrossRef
60.
Duffy RMSY, Feinberg AW. Understanding the role of ECM protein composition and geometric micropatterning for engineering human skeletal muscle. Ann Biomed Eng. 2016;44:2076–89.PubMedCrossRef
61.
62.
Bertassoni LE, Cardoso JC, Manoharan V, Cristino AL, Bhise NS, Araujo WA, Zorlutuna P, Vrana NE, Ghaemmaghami AM, Dokmeci MR, Khademhosseini A. Direct-write bioprinting of cell-laden methacrylated gelatin hydrogels. Biofabrication. 2014;6:024105.PubMedPubMedCentralCrossRef
63.
Neufurth M, Wang X, Schroder HC, Feng Q, Diehl-Seifert B, Ziebart T, Steffen R, Wang S, Muller WE. Engineering a morphogenetically active hydrogel for bioprinting of bioartificial tissue derived from human osteoblast-like SaOS-2 cells. Biomaterials. 2014;35:8810–9.PubMedCrossRef
64.
Lorber B, Hsiao WK, Hutchings IM, Martin KR. Adult rat retinal ganglion cells and glia can be printed by piezoelectric inkjet printing. Biofabrication. 2014;6:015001.PubMedCrossRef
65.
Levato R, Visser J, Planell JA, Engel E, Malda J, Mateos-Timoneda MA. Biofabrication of tissue constructs by 3D bioprinting of cell-laden microcarriers. Biofabrication. 2014;6:035020.PubMedCrossRef
66.
Duarte Campos DF, Blaeser A, Weber M, Jakel J, Neuss S, Jahnen-Dechent W, Fischer H. Three-dimensional printing of stem cell-laden hydrogels submerged in a hydrophobic high-density fluid. Biofabrication. 2013;5:015003.PubMedCrossRef
67.
Gruene M, Deiwick A, Koch L, Schlie S, Unger C, Hofmann N, Bernemann I, Glasmacher B, Chichkov B. Laser printing of stem cells for biofabrication of scaffold-free autologous grafts. Tissue Eng Part C Methods. 2011;17:79–87.PubMedCrossRef
68.
Lin H, Zhang D, Alexander PG, Yang G, Tan J, Cheng AW, Tuan RS. Application of visible light-based projection stereolithography for live cell-scaffold fabrication with designed architecture. Biomaterials. 2013;34:331–9.PubMedCrossRef
69.
Moon S, Kim Y-G, Dong L, Lombardi M, Haeggstrom E, Jensen RV, Hsiao L-L, Demirci U. Drop-on-demand single cell isolation and total RNA analysis. PLoS ONE. 2011;6:e17455.PubMedPubMedCentralCrossRef
70.
Ma Z, Liu Q, Yang H, Runyan RB, Eisenberg CA, Xu M, Borg TK, Markwald R, Wang Y, Gao BZ. Laser patterning for the study of MSC cardiogenic differentiation at the single-cell level. Light Sci Appl. 2013;2:e68.CrossRef
71.
Dinh ND, Chiang YY, Hardelauf H, Baumann J, Jackson E, Waide S, Sisnaiske J, Frimat JP, van Thriel C, Janasek D, et al. Microfluidic construction of minimalistic neuronal co-cultures. Lab Chip. 2013;13:1402–12.PubMedCrossRef
72.
Roth EA, Xu T, Das M, Gregory C, Hickman JJ, Boland T. Inkjet printing for high-throughput cell patterning. Biomaterials. 2004;25:3707–15.PubMedCrossRef
73.
Campbell PG, Miller ED, Fisher GW, Walker LM, Weiss LE. Engineered spatial patterns of FGF-2 immobilized on fibrin direct cell organization. Biomaterials. 2005;26:6762–70.PubMedCrossRef
74.
Skardal A, Zhang J, Prestwich GD. Bioprinting vessel-like constructs using hyaluronan hydrogels crosslinked with tetrahedral polyethylene glycol tetracrylates. Biomaterials. 2010;31:6173–81.PubMedCrossRef
75.
Beyersdorf F. Three-dimensional bioprinting: new horizon for cardiac surgery. Eur J Cardiothorac Surg. 2014;46:339–41.PubMedCrossRef
76.
Sawkins MJ, Mistry P, Brown BN, Shakesheff KM, Bonassar LJ, Yang J. Cell and protein compatible 3D bioprinting of mechanically strong constructs for bone repair. Biofabrication. 2015;7:035004.PubMedCrossRef
77.
Markstedt K, Mantas A, Tournier I, Martinez Avila H, Hagg D, Gatenholm P. 3D bioprinting human chondrocytes with nanocellulose-alginate bioink for cartilage tissue engineering applications. Biomacromolecules. 2015;16:1489–96.PubMedCrossRef
78.
Bernhard JC, Isotani S, Matsugasumi T, Duddalwar V, Hung AJ, Suer E, Baco E, Satkunasivam R, Djaladat H, Metcalfe C, et al. Personalized 3D printed model of kidney and tumor anatomy: a useful tool for patient education. World J Urol. 2016;34:337–45.PubMedCrossRef
79.
Skardal A, Mack D, Kapetanovic E, Atala A, Jackson JD, Yoo J, Soker S. Bioprinted amniotic fluid-derived stem cells accelerate healing of large skin wounds. Stem Cells Transl Med. 2012;1:792–802.PubMedPubMedCentralCrossRef
80.
Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Borden WB, Bravata DM, Dai S, Ford ES, Fox CS, Franco S, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Huffman MD, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Magid D, Marcus GM, Marelli A, Matchar DB, McGuire DK, Mohler ER, Moy CS, Mussolino ME, Nichol G, Paynter NP, Schreiner PJ, Sorlie PD, Stein J, Turan TN, Virani SS, Wong ND, Woo D, Turner MB, American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics—2013 update: a report from the American Heart Association. Circulation. 2012;127:e6–245. doi:10.​1161/​CIR.​0b013e31828124ad​.
81.
Bertassoni LE, Cecconi M, Manoharan V, Nikkhah M, Hjortnaes J, Cristino AL, Barabaschi G, Demarchi D, Dokmeci MR, Yang Y, Khademhosseini A. Hydrogel bioprinted microchannel networks for vascularization of tissue engineering constructs. Lab Chip. 2014;14:2202–11.PubMedPubMedCentralCrossRef
82.
Kolesky DB, Truby RL, Gladman AS, Busbee TA, Homan KA, Lewis JA. 3D bioprinting of vascularized, heterogeneous cell-laden tissue constructs. Adv Mater. 2014;26:3124–30.PubMedCrossRef
83.
Duan B, Kapetanovic E, Hockaday LA, Butcher JT. Three-dimensional printed trileaflet valve conduits using biological hydrogels and human valve interstitial cells. Acta Biomater. 2014;10:1836–46.PubMedCrossRef
84.
Chen W, Zhou H, Tang M, Weir MD, Bao C, Xu HH. Gas-foaming calcium phosphate cement scaffold encapsulating human umbilical cord stem cells. Tissue Eng Part A. 2012;18:816–27.PubMedCrossRef
85.
Thein-Han W, Xu HH. Prevascularization of a gas-foaming macroporous calcium phosphate cement scaffold via coculture of human umbilical vein endothelial cells and osteoblasts. Tissue Eng Part A. 2013;19:1675–85.PubMedPubMedCentralCrossRef
86.
Kim TG, Chung HJ, Park TG. Macroporous and nanofibrous hyaluronic acid/collagen hybrid scaffold fabricated by concurrent electrospinning and deposition/leaching of salt particles. Acta Biomater. 2008;4:1611–9.PubMedCrossRef
87.
Mehrabanian M, Nasr-Esfahani M. HA/nylon 6,6 porous scaffolds fabricated by salt-leaching/solvent casting technique: effect of nano-sized filler content on scaffold properties. Int J Nanomedicine. 2011;6:1651–9.PubMedPubMedCentral
88.
Gercek I, Tigli RS, Gumusderelioglu M. A novel scaffold based on formation and agglomeration of PCL microbeads by freeze-drying. J Biomed Mater Res A. 2008;86:1012–22.PubMedCrossRef
89.
Alizadeh M, Abbasi F, Khoshfetrat AB, Ghaleh H. Microstructure and characteristic properties of gelatin/chitosan scaffold prepared by a combined freeze-drying/leaching method. Mater Sci Eng C Mater Biol Appl. 2013;33:3958–67.PubMedCrossRef
90.
Castilho M, Moseke C, Ewald A, Gbureck U, Groll J, Pires I, Tessmar J, Vorndran E. Direct 3D powder printing of biphasic calcium phosphate scaffolds for substitution of complex bone defects. Biofabrication. 2014;6:015006.PubMedCrossRef
91.
Gao G, Schilling AF, Yonezawa T, Wang J, Dai G, Cui X. Bioactive nanoparticles stimulate bone tissue formation in bioprinted three-dimensional scaffold and human mesenchymal stem cells. Biotechnol J. 2014;9:1304–11.PubMedCrossRef
92.
Park JY, Choi JC, Shim JH, Lee JS, Park H, Kim SW, Doh J, Cho DW. A comparative study on collagen type I and hyaluronic acid dependent cell behavior for osteochondral tissue bioprinting. Biofabrication. 2014;6:035004.PubMedCrossRef
93.
Lee V, Singh G, Trasatti JP, Bjornsson C, Xu X, Tran TN, Yoo SS, Dai G, Karande P. Design and fabrication of human skin by three-dimensional bioprinting. Tissue Eng Part C Methods. 2014;20:473–84.PubMedCrossRef
94.
Zein NN, Hanouneh IA, Bishop PD, Samaan M, Eghtesad B, Quintini C, Miller C, Yerian L, Klatte R. Three-dimensional print of a liver for preoperative planning in living donor liver transplantation. Liver Transpl. 2013;19:1304–10.PubMedCrossRef
95.
Bale SS, Vernetti L, Senutovitch N, Jindal R, Hegde M, Gough A, McCarty WJ, Bakan A, Bhushan A, Shun TY, et al. In vitro platforms for evaluating liver toxicity. Exp Biol Med. 2014;239:1180–91.CrossRef
96.
Ikegami T, Maehara Y. Transplantation: 3D printing of the liver in living donor liver transplantation. Nat Rev Gastroenterol Hepatol. 2013;10:697–8.PubMedCrossRef
97.
Nakao Y, Kimura H, Sakai Y, Fujii T. Bile canaliculi formation by aligning rat primary hepatocytes in a microfluidic device. Biomicrofluidics. 2011;5:22212.PubMedCrossRef
98.
Skardal A, Smith L, Bharadwaj S, Atala A, Soker S, Zhang Y. Tissue specific synthetic ECM hydrogels for 3D in vitro maintenance of hepatocyte function. Biomaterials. 2012;33:4565–75.PubMedPubMedCentralCrossRef
99.
Chang R, Emami K, Wu H, Sun W. Biofabrication of a three-dimensional liver micro-organ as an in vitro drug metabolism model. Biofabrication. 2010;2:045004.PubMedCrossRef
100.
Zhu MZJ. Three-dimensional printing of cerium-incorporated mesoporous calcium-silicate scaffolds for bone repair. J Mater Sci. 2016;51:836–44.CrossRef
101.
Chang RC, Emami K, Jeevarajan A, Wu H, Sun W. Microprinting of liver micro-organ for drug metabolism study. Methods Mol Biol. 2011;671:219–38.PubMedCrossRef
102.
Chien KB, Aguado BA, Bryce PJ, Shah RN. In vivo acute and humoral response to three-dimensional porous soy protein scaffolds. Acta Biomater. 2013;9:8983–90.PubMedCrossRef
103.
Haberstroh K, Ritter K, Kuschnierz J, Bormann KH, Kaps C, Carvalho C, Mulhaupt R, Sittinger M, Gellrich NC. Bone repair by cell-seeded 3D-bioplotted composite scaffolds made of collagen treated tricalciumphosphate or tricalciumphosphate-chitosan-collagen hydrogel or PLGA in ovine critical-sized calvarial defects. J Biomed Mater Res B Appl Biomater. 2010;93:520–30.PubMedCrossRef
104.
Lim TC, Chian KS, Leong KF. Cryogenic prototyping of chitosan scaffolds with controlled micro and macro architecture and their effect on in vivo neo-vascularization and cellular infiltration. J Biomed Mater Res A. 2010;94:1303–11.PubMed
105.
Fielding GA, Bandyopadhyay A, Bose S. Effects of silica and zinc oxide doping on mechanical and biological properties of 3D printed tricalcium phosphate tissue engineering scaffolds. Dent Mater. 2012;28:113–22.PubMedCrossRef
106.
Gao L, Li C, Chen F, Liu C. Fabrication and characterization of toughness-enhanced scaffolds comprising beta-TCP/POC using the freeform fabrication system with micro-droplet jetting. Biomed Mater. 2015;10:035009.PubMedCrossRef
107.
Chang CH, Lin CY, Liu FH, Chen MH, Lin CP, Ho HN, Liao YS. 3D printing bioceramic porous scaffolds with good mechanical property and cell affinity. PLoS ONE. 2015;10:e0143713.PubMedPubMedCentralCrossRef
108.
Tarafder S, Dernell WS, Bandyopadhyay A, Bose S. SrO- and MgO-doped microwave sintered 3D printed tricalcium phosphate scaffolds: mechanical properties and in vivo osteogenesis in a rabbit model. J Biomed Mater Res B Appl Biomater. 2015;103:679–90.PubMedCrossRef
109.
Cox SC, Thornby JA, Gibbons GJ, Williams MA, Mallick KK. 3D printing of porous hydroxyapatite scaffolds intended for use in bone tissue engineering applications. Mater Sci Eng C Mater Biol Appl. 2015;47:237–47.PubMedCrossRef
110.
Luo Y, Zhai D, Huan Z, Zhu H, Xia L, Chang J, Wu C. Three-dimensional printing of hollow-struts-packed bioceramic scaffolds for bone regeneration. ACS Appl Mater Interfaces. 2015;7:24377–83.PubMedCrossRef
111.
Paulsen SJ, Miller JS. Tissue vascularization through 3D printing: will technology bring us flow? Dev Dyn. 2015;244:629–40.PubMedCrossRef
112.
Bose SVS, Bandyopadhyay A. Bone tissue engineering using 3D printing. Mater Today. 2013;16:496–504.CrossRef
113.
Xia Y, Zhou P, Cheng X, Xie Y, Liang C, Li C, Xu S. Selective laser sintering fabrication of nano-hydroxyapatite/poly-epsilon-caprolactone scaffolds for bone tissue engineering applications. Int J Nanomedicine. 2013;8:4197–213.PubMedPubMedCentral
114.
Lee JW, Choi YJ, Yong WJ, Pati F, Shim JH, Kang KS, Kang IH, Park J, Cho DW. Development of a 3D cell printed construct considering angiogenesis for liver tissue engineering. Biofabrication. 2016;8:015007.PubMedCrossRef
Metadata
Title
Recent advances in bioprinting techniques: approaches, applications and future prospects
Authors
Jipeng Li
Mingjiao Chen
Xianqun Fan
Huifang Zhou
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Journal of Translational Medicine / Issue 1/2016
Electronic ISSN: 1479-5876
DOI
https://doi.org/10.1186/s12967-016-1028-0

Other articles of this Issue 1/2016

Journal of Translational Medicine 1/2016 Go to the issue

Research

Leptin decreases the expression of low-density lipoprotein receptor via PCSK9 pathway: linking dyslipidemia with obesity

Research

Activation of myeloid dendritic cells, effector cells and regulatory T cells in lichen planus

Research

Safety and feasibility of cell-based therapy of autologous bone marrow-derived mononuclear cells in plate-stabilized proximal humeral fractures in humans

Methodology

Kinetics of human myeloid-derived suppressor cells after blood draw

Research

Next-generation sequencing for diagnosis of thoracic aortic aneurysms and dissections: diagnostic yield, novel mutations and genotype phenotype correlations

Research

Oncolytic virus efficiency inhibited growth of tumour cells with multiple drug resistant phenotype in vivo and in vitro
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Heart Failure Video

Year in Review: Heart failure and cardiomyopathies

Watch now

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits