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Journal of Translational Medicine
Published in: Journal of Translational Medicine 1/2015

Open Access 01-12-2015 | Research

Obesity susceptibility loci in Qataris, a highly consanguineous Arabian population

Authors: Sara Tomei, Ravinder Mamtani, Rashid Al Ali, Naser Elkum, Maryam Abdulmalik, Awatef Ismail, Sohaila Cheema, Hekmat A Rouh, Idil I Aigha, Fatima Hani, Sura Al-Samraye, Mona Taher Aseel, Nada El Emadi, Azza Al Mujalli, Ahmed Abdelkerim, Siddik Youssif, Andrea Worschech, Emad El Sebakhy, Ramzi Temanni, Vineesh Khanna, Ena Wang, Dhanya Kizhakayil, Al-Anood Al-Thani, Mohammed Al-Thani, Albert Lowenfels, Francesco M Marincola, Javaid Sheikh, Lotfi Chouchane

Published in: Journal of Translational Medicine | Issue 1/2015

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Abstract

Objectives

In Qataris, a population characterized by a small size and a high rate of consanguinity, between two-thirds to three-quarters of adults are overweight or obese. We investigated the relevance of 23 obesity-related loci in the Qatari population.

Methods

Eight-hundred-four individuals assessed to be third generation Qataris were included in the study and assigned to 3 groups according to their body mass index (BMI): 190 lean (BMI < 25 kg/m2); 131 overweight (25 kg/m2 ≤ BMI < 30 kg/m2) and 483 obese (BMI ≥ 30 kg/m2). Genomic DNA was isolated from peripheral blood and genotyped by TaqMan.

Results

Two loci significantly associated with obesity in Qataris: the TFAP2B variation (rs987237) (A allele versus G allele: chi-square = 10.3; P = 0.0013) and GNPDA2 variation (rs10938397) (A allele versus G allele: chi-square = 6.15; P = 0.013). The TFAP2B GG genotype negatively associated with obesity (OR = 0.21; P = 0.0031). Conversely, the GNDPA2 GG homozygous genotype associated with higher risk of obesity in subjects of age < 32 years (P = 0.0358).

Conclusion

We showed a different genetic profile associated with obesity in the Qatari population compared to Western populations. Studying the genetic background of Qataris is of primary importance as the etiology of a given disease might be population-specific.
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Literature
1.
Grundy SM. Obesity, metabolic syndrome, and cardiovascular disease. J Clin Endocrinol Metab. 2004;89:2595–600.CrossRefPubMed
2.
Bohm A, Halama A, Meile T, Zdichavsky M, Lehmann R, Weigert C, et al. Metabolic signatures of cultured human adipocytes from metabolically healthy versus unhealthy obese individuals. PLoS One. 2014;9:e93148.CrossRefPubMedCentralPubMed
3.
Mozaffarian D, Hao T, Rimm EB, Willett WC, Hu FB. Changes in diet and lifestyle and long-term weight gain in women and men. N Engl J Med. 2011;364:2392–404.CrossRefPubMedCentralPubMed
4.
5.
6.
Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V, et al. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet. 2010;42:949–60.CrossRefPubMedCentralPubMed
7.
8.
Scherag A, Dina C, Hinney A, Vatin V, Scherag S, Vogel CI, et al. Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups. PLoS Genet. 2010;6:e1000916.CrossRefPubMedCentralPubMed
9.
Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet. 2010;42:937–48.CrossRefPubMedCentralPubMed
10.
Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet. 2009;41:25–34.CrossRefPubMedCentralPubMed
11.
Bener A, Hussain R. Consanguineous unions and child health in the State of Qatar. Paediatr Perinat Epidemiol. 2006;20:372–8.CrossRefPubMed
12.
Ng SW, Zaghloul S, Ali HI, Harrison G, Popkin BM. The prevalence and trends of overweight, obesity and nutrition-related non-communicable diseases in the Arabian Gulf States. Obes Rev. 2011;12:1–13.CrossRefPubMed
13.
Ntzani EE, Liberopoulos G, Manolio TA, Ioannidis JP. Consistency of genome-wide associations across major ancestral groups. Hum Genet. 2012;131:1057–71.CrossRefPubMed
14.
Burchard EG, Ziv E, Coyle N, Gomez SL, Tang H, Karter AJ, et al. The importance of race and ethnic background in biomedical research and clinical practice. N Engl J Med. 2003;348:1170–5.CrossRefPubMed
15.
Chevin LM, Billiard S, Hospital F. Hitchhiking both ways: effect of two interfering selective sweeps on linked neutral variation. Genetics. 2008;180:301–16.CrossRefPubMedCentralPubMed
16.
Currat M, Trabuchet G, Rees D, Perrin P, Harding RM, Clegg JB, et al. Molecular analysis of the beta-globin gene cluster in the Niokholo Mandenka population reveals a recent origin of the beta(S) Senegal mutation. Am J Hum Genet. 2002;70:207–23.CrossRefPubMedCentralPubMed
17.
Corona E, Chen R, Sikora M, Morgan AA, Patel CJ, Ramesh A, et al. Analysis of the genetic basis of disease in the context of worldwide human relationships and migration. PLoS Genet. 2013;9:e1003447.CrossRefPubMedCentralPubMed
18.
Thorleifsson G, Walters GB, Gudbjartsson DF, Steinthorsdottir V, Sulem P, Helgadottir A, et al. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet. 2009;41:18–24.CrossRefPubMed
19.
Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, Prokopenko I, et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet. 2008;40:768–75.CrossRefPubMedCentralPubMed
20.
Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science. 2007;316:889–94.CrossRefPubMedCentralPubMed
21.
Scuteri A, Sanna S, Chen WM, Uda M, Albai G, Strait J, et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet. 2007;3:e115.CrossRefPubMedCentralPubMed
22.
Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V, Qi L, et al. Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet. 2009;5:e1000508.CrossRefPubMedCentralPubMed
23.
Giardina E, Pietrangeli I, Martinez-Labarga C, Martone C, de Angelis F, Spinella A, et al. Haplotypes in SLC24A5 Gene as Ancestry Informative Markers in Different Populations. Curr Genomics. 2008;9:110–4.CrossRefPubMedCentralPubMed
24.
Mejia-Benitez A, Klunder-Klunder M, Yengo L, Meyre D, Aradillas C, Cruz E, et al. Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican children. BMC Med Genet. 2013;14:21.CrossRefPubMedCentralPubMed
25.
Ugi S, Nishio Y, Yamamoto H, Ikeda K, Kobayashi M, Tsukada S, et al. Relation of the expression of transcriptional factor TFAP2B to that of adipokines in subcutaneous and omental adipose tissues. Obesity (Silver Spring). 2010;18:1277–82.CrossRef
26.
Tao Y, Maegawa H, Ugi S, Ikeda K, Nagai Y, Egawa K, et al. The transcription factor AP-2beta causes cell enlargement and insulin resistance in 3 T3-L1 adipocytes. Endocrinology. 2006;147:1685–96.CrossRefPubMed
27.
Ikeda K, Maegawa H, Ugi S, Tao Y, Nishio Y, Tsukada S, et al. Transcription factor activating enhancer-binding protein-2beta. A negative regulator of adiponectin gene expression. J Biol Chem. 2006;281:31245–53.CrossRefPubMed
28.
Wang X, Tang NL, Leung CC, Kam KM, Yew WW, Tam CM, et al. Association of polymorphisms in the Chr18q11.2 locus with tuberculosis in Chinese population. Hum Genet. 2013;132:691–5.CrossRefPubMed
29.
Fukuda H, Imamura M, Tanaka Y, Iwata M, Hirose H, Kaku K, et al. Replication study for the association of a single-nucleotide polymorphism, rs3746876, within KCNJ15, with susceptibility to type 2 diabetes in a Japanese population. J Hum Genet. 2013;58:490–3.CrossRefPubMed
30.
Albuquerque D, Nobrega C, Rodriguez-Lopez R, Manco L. Association study of common polymorphisms in MSRA, TFAP2B, MC4R, NRXN3, PPARGC1A, TMEM18, SEC16B, HOXB5 and OLFM4 genes with obesity-related traits among Portuguese children. J Hum Genet. 2014;59(6):307–13.CrossRefPubMed
31.
Cheung CY, Tso AW, Cheung BM, Xu A, Ong KL, Fong CH, et al. Obesity susceptibility genetic variants identified from recent genome-wide association studies: implications in a chinese population. J Clin Endocrinol Metab. 2010;95:1395–403.CrossRefPubMed
32.
Takeuchi F, Yamamoto K, Katsuya T, Nabika T, Sugiyama T, Fujioka A, et al. Association of genetic variants for susceptibility to obesity with type 2 diabetes in Japanese individuals. Diabetologia. 2011;54:1350–9.CrossRefPubMed
33.
Xi B, Zhao X, Shen Y, Wu L, Hou D, Cheng H, et al. An obesity genetic risk score predicts risk of insulin resistance among Chinese children. Endocrine. 2014;47:825–32.CrossRefPubMed
34.
35.
Shimaoka I, Kamide K, Ohishi M, Katsuya T, Akasaka H, Saitoh S, et al. Association of gene polymorphism of the fat-mass and obesity-associated gene with insulin resistance in Japanese. Hypertens Res. 2010;33:214–8.CrossRefPubMed
Metadata
Title
Obesity susceptibility loci in Qataris, a highly consanguineous Arabian population
Authors
Sara Tomei
Ravinder Mamtani
Rashid Al Ali
Naser Elkum
Maryam Abdulmalik
Awatef Ismail
Sohaila Cheema
Hekmat A Rouh
Idil I Aigha
Fatima Hani
Sura Al-Samraye
Mona Taher Aseel
Nada El Emadi
Azza Al Mujalli
Ahmed Abdelkerim
Siddik Youssif
Andrea Worschech
Emad El Sebakhy
Ramzi Temanni
Vineesh Khanna
Ena Wang
Dhanya Kizhakayil
Al-Anood Al-Thani
Mohammed Al-Thani
Albert Lowenfels
Francesco M Marincola
Javaid Sheikh
Lotfi Chouchane
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Journal of Translational Medicine / Issue 1/2015
Electronic ISSN: 1479-5876
DOI
https://doi.org/10.1186/s12967-015-0459-3

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