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Journal of Translational Medicine
Published in: Journal of Translational Medicine 1/2014

Open Access 01-12-2014 | Research

The prognostic value of microRNA-126 and microvessel density in patients with stage II colon cancer: results from a population cohort

Authors: Torben Frøstrup Hansen, Sanne Kjær-Frifeldt, Søren Morgenthaler, Thorarinn Blondal, Jan Lindebjerg, Anders Jakobsen, Flemming Brandt Sørensen

Published in: Journal of Translational Medicine | Issue 1/2014

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Abstract

Background

Angiogenesis plays a pivotal role in malignant tumour growth and the metastatic process. We analysed the prognostic value of two angiogenesis parameters, microRNA-126 (miRNA-126) and microvessel density (MVD), in a population based cohort of patients operated for stage II colon cancer.

Methods

A total of 560 patients were included. Analyses were performed on formalin fixed paraffin embedded tissue from the primary tumours. The analysis of miRNA-126 expression was performed by qPCR. Microvessels were visualised by CD105 and quantified in hot spots using a light microscope. The analyses were correlated with recurrence-free cancer specific survival (RF-CSS) and overall survival (OS).

Results

Low miRNA-126 expression was significantly correlated to T4, high malignancy grade, tumour perforation, fixation, and the presence of microsatellite instability. A prognostic impact on OS was detected in the simple analysis favouring patients with high miRNA-126 expression p = 0.03, and borderline significance as to RF-CSS, p = 0.08. The impact on OS demonstrated borderline significance in a following multiple Cox regression analysis, hazard ratio 0.76 (95% confidence interval, 0.58-1.00), p = 0.051. The MVD estimate was not associated with either RF-CSS, p = 0.49, or OS, p = 0.94.

Conclusion

The current population based study of patients operated for stage II colon cancer demonstrated correlations between several prognostic unfavourable characteristics and miRNA-126 and argues for a possible prognostic impact on overall survival. An influence on survival by the MVD estimate was not detected.
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Metadata
Title
The prognostic value of microRNA-126 and microvessel density in patients with stage II colon cancer: results from a population cohort
Authors
Torben Frøstrup Hansen
Sanne Kjær-Frifeldt
Søren Morgenthaler
Thorarinn Blondal
Jan Lindebjerg
Anders Jakobsen
Flemming Brandt Sørensen
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Journal of Translational Medicine / Issue 1/2014
Electronic ISSN: 1479-5876
DOI
https://doi.org/10.1186/s12967-014-0254-6

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