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Published in: Thrombosis Journal 1/2021

Open Access 01-12-2021 | Ticagrelor | Research

Clopidogrel versus ticagrelor in the treatment of Chinese patients undergoing percutaneous coronary intervention: effects on platelet function assessed by platelet function tests and mean platelet volume

Authors: Yang Zhang, Rui Peng, Xiaojuan Li, Gaowa Cheng, Ximing Wang, Jinxing Yu, Muxing Hua, Xi Chen, Zhou Zhou

Published in: Thrombosis Journal | Issue 1/2021

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Abstract

Background

Knowledge on the pharmacodynamic effects of antiplatelet drugs including clopidogrel and ticagrelor on Asian patients is scarce. We aim to evaluate the effects of the two drugs on platelet reactivity in the treatment of Chinese patients who underwent percutaneous coronary intervention (PCI), using two platelet function tests (PFT). Meanwhile, the relationship between mean platelet volume (MPV), a routine index of platelet size, and high on-treatment platelet reactivity (HPR) is also investigated.

Methods

Patients receiving dual antiplatelet therapy (DAPT) were scheduled for the assessment of platelet reactivity at 2–3 days after PCI. Two PFTs, light transmission aggregometry (LTA) and vasodilator-stimulated phosphoprotein (VASP)-FCM assay, were applied in the evaluation of platelet reactivity. The MPV was measured simultaneously with EDTA plasma using a Sysmex XN 2000 automated hematology analyzer.

Results

The final study population included the aspirin + clopidogrel group (n = 46) and the aspirin + ticagrelor group (n = 66). In the aspirin + ticagrelor group, the maximal light transmittance (LT) changes in response to 5 μM ADP assessed by LTA was obviously lower than that in the aspirin + clopidogrel group (P <  0.001). The platelet reactivity index (PRI) level in the VASP test was also markedly lower in the group given aspirin and ticagrelor (P <  0.001). There was a significant difference in HPR between the two groups. MPV showed a potent ability to predict the presence of HPR at VASP assay (AUC = 0.788, 95% CI: 0.701–0.875, P <  0.001) in receiver-operating characteristic curve analysis.

Conclusions

Compared with clopidogrel, ticagrelor has dramatically greater antiplatelet effect, with a superiority in suppressing platelet function and a lower HPR rate. In addition, there existed a significant independent association between MPV and high prevalence of HPR in the VASP assay.
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Literature
1.
go back to reference Steinhubl SR, Berger PB, Mann JT 3rd, Fry ET, DeLago A, Wilmer C, et al. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial. Jama. 2002;288:2411–20.PubMedCrossRef Steinhubl SR, Berger PB, Mann JT 3rd, Fry ET, DeLago A, Wilmer C, et al. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial. Jama. 2002;288:2411–20.PubMedCrossRef
2.
go back to reference Yusuf S, Zhao F, Mehta SR, Chrolavicius S, Tognoni G, Fox KK. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med. 2001;345:494–502.PubMedCrossRef Yusuf S, Zhao F, Mehta SR, Chrolavicius S, Tognoni G, Fox KK. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med. 2001;345:494–502.PubMedCrossRef
3.
go back to reference Gurbel PA, Bliden KP, Hiatt BL, O'Connor CM. Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pretreatment platelet reactivity. Circulation. 2003;107:2908–13.PubMedCrossRef Gurbel PA, Bliden KP, Hiatt BL, O'Connor CM. Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pretreatment platelet reactivity. Circulation. 2003;107:2908–13.PubMedCrossRef
4.
go back to reference van der Heijden DJ, Westendorp IC, Riezebos RK, Kiemeneij F, Slagboom T, van der Wieken LR, et al. Lack of efficacy of clopidogrel pre-treatment in the prevention of myocardial damage after elective stent implantation. J Am Coll Cardiol. 2004;44:20–4.PubMedCrossRef van der Heijden DJ, Westendorp IC, Riezebos RK, Kiemeneij F, Slagboom T, van der Wieken LR, et al. Lack of efficacy of clopidogrel pre-treatment in the prevention of myocardial damage after elective stent implantation. J Am Coll Cardiol. 2004;44:20–4.PubMedCrossRef
5.
go back to reference Bonello L, Tantry US, Marcucci R, Blindt R, Angiolillo DJ, Becker R, et al. Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate. J Am Coll Cardiol. 2010;56:919–33.PubMedCrossRef Bonello L, Tantry US, Marcucci R, Blindt R, Angiolillo DJ, Becker R, et al. Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate. J Am Coll Cardiol. 2010;56:919–33.PubMedCrossRef
6.
go back to reference Marcucci R, Gori AM, Paniccia R, Giusti B, Valente S, Giglioli C, et al. Cardiovascular death and nonfatal myocardial infarction in acute coronary syndrome patients receiving coronary stenting are predicted by residual platelet reactivity to ADP detected by a point-of-care assay: a 12-month follow-up. Circulation. 2009;119:237–42.PubMedCrossRef Marcucci R, Gori AM, Paniccia R, Giusti B, Valente S, Giglioli C, et al. Cardiovascular death and nonfatal myocardial infarction in acute coronary syndrome patients receiving coronary stenting are predicted by residual platelet reactivity to ADP detected by a point-of-care assay: a 12-month follow-up. Circulation. 2009;119:237–42.PubMedCrossRef
7.
go back to reference Vang JJ, Nilsson L, Berntsson P, Wissing BM, Giordanetto F, Tomlinson W, et al. Ticagrelor binds to human P2Y(12) independently from ADP but antagonizes ADP-induced receptor signaling and platelet aggregation. J Thromb Haemost. 2009;7:1556–65.CrossRef Vang JJ, Nilsson L, Berntsson P, Wissing BM, Giordanetto F, Tomlinson W, et al. Ticagrelor binds to human P2Y(12) independently from ADP but antagonizes ADP-induced receptor signaling and platelet aggregation. J Thromb Haemost. 2009;7:1556–65.CrossRef
8.
go back to reference May CH, Lincoff AM. Safety profile and bleeding risk of ticagrelor compared with clopidogrel. Expert Opin Drug Saf. 2012;11:959–67.PubMedCrossRef May CH, Lincoff AM. Safety profile and bleeding risk of ticagrelor compared with clopidogrel. Expert Opin Drug Saf. 2012;11:959–67.PubMedCrossRef
9.
go back to reference Franchi F, Faz GT, Rollini F, Park Y, Cho JR, Thano E, et al. Pharmacodynamic effects of switching from Prasugrel to Ticagrelor: results of the prospective, randomized SWAP-3 study. JACC Cardiovasc Interv. 2016;9:1089–98.PubMedCrossRef Franchi F, Faz GT, Rollini F, Park Y, Cho JR, Thano E, et al. Pharmacodynamic effects of switching from Prasugrel to Ticagrelor: results of the prospective, randomized SWAP-3 study. JACC Cardiovasc Interv. 2016;9:1089–98.PubMedCrossRef
10.
go back to reference Levine GN, Bates ER, Bittl JA, Brindis RG, Fihn SD, Fleisher LA, et al. 2016 ACC/AHA guideline focused update on duration of dual antiplatelet therapy in patients with coronary artery disease: a report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines: an update of the 2011 ACCF/AHA/SCAI guideline for percutaneous coronary intervention, 2011 ACCF/AHA guideline for coronary artery bypass graft surgery, 2012 ACC/AHA/ACP/AATS/PCNA/SCAI/STS guideline for the diagnosis and Management of Patients with Stable Ischemic Heart Disease, 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction, 2014 AHA/ACC guideline for the Management of Patients with non-ST-elevation acute coronary syndromes, and 2014 ACC/AHA guideline on perioperative cardiovascular evaluation and Management of Patients Undergoing Noncardiac Surgery. Circulation. 2016;134:e123–55.PubMed Levine GN, Bates ER, Bittl JA, Brindis RG, Fihn SD, Fleisher LA, et al. 2016 ACC/AHA guideline focused update on duration of dual antiplatelet therapy in patients with coronary artery disease: a report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines: an update of the 2011 ACCF/AHA/SCAI guideline for percutaneous coronary intervention, 2011 ACCF/AHA guideline for coronary artery bypass graft surgery, 2012 ACC/AHA/ACP/AATS/PCNA/SCAI/STS guideline for the diagnosis and Management of Patients with Stable Ischemic Heart Disease, 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction, 2014 AHA/ACC guideline for the Management of Patients with non-ST-elevation acute coronary syndromes, and 2014 ACC/AHA guideline on perioperative cardiovascular evaluation and Management of Patients Undergoing Noncardiac Surgery. Circulation. 2016;134:e123–55.PubMed
11.
go back to reference Kang J, Park KW, Palmerini T, Stone GW, Lee MS, Colombo A, et al. Racial differences in Ischaemia/bleeding risk trade-off during anti-platelet therapy: individual patient level landmark Meta-analysis from seven RCTs. Thromb Haemost. 2019;119:149–62.PubMedCrossRef Kang J, Park KW, Palmerini T, Stone GW, Lee MS, Colombo A, et al. Racial differences in Ischaemia/bleeding risk trade-off during anti-platelet therapy: individual patient level landmark Meta-analysis from seven RCTs. Thromb Haemost. 2019;119:149–62.PubMedCrossRef
12.
go back to reference Park DW, Kwon O, Jang JS, Yun SC, Park H, Kang DY, et al. Clinically significant bleeding with Ticagrelor versus Clopidogrel in Korean patients with acute coronary syndromes intended for invasive management: a randomized clinical trial. Circulation. 2019;140:1865–77.PubMedCrossRef Park DW, Kwon O, Jang JS, Yun SC, Park H, Kang DY, et al. Clinically significant bleeding with Ticagrelor versus Clopidogrel in Korean patients with acute coronary syndromes intended for invasive management: a randomized clinical trial. Circulation. 2019;140:1865–77.PubMedCrossRef
13.
go back to reference Goto S, Huang CH, Park SJ, Emanuelsson H, Kimura T. Ticagrelor vs. clopidogrel in Japanese, Korean and Taiwanese patients with acute coronary syndrome -- randomized, double-blind, phase III PHILO study. Circ J. 2015;79:2452–60.PubMedCrossRef Goto S, Huang CH, Park SJ, Emanuelsson H, Kimura T. Ticagrelor vs. clopidogrel in Japanese, Korean and Taiwanese patients with acute coronary syndrome -- randomized, double-blind, phase III PHILO study. Circ J. 2015;79:2452–60.PubMedCrossRef
14.
go back to reference Gorog DA, Fuster V. Platelet function tests in clinical cardiology: unfulfilled expectations. J Am Coll Cardiol. 2013;61:2115–29.PubMedCrossRef Gorog DA, Fuster V. Platelet function tests in clinical cardiology: unfulfilled expectations. J Am Coll Cardiol. 2013;61:2115–29.PubMedCrossRef
15.
go back to reference Kong R, Trimmings A, Hutchinson N, Gill R, Agarwal S, Davidson S, et al. Consensus recommendations for using the multiplate((R)) for platelet function monitoring before cardiac surgery. Int J Lab Hematol. 2015;37:143–7.PubMedCrossRef Kong R, Trimmings A, Hutchinson N, Gill R, Agarwal S, Davidson S, et al. Consensus recommendations for using the multiplate((R)) for platelet function monitoring before cardiac surgery. Int J Lab Hematol. 2015;37:143–7.PubMedCrossRef
17.
go back to reference Born GV. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature. 1962;194:927–9.PubMedCrossRef Born GV. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature. 1962;194:927–9.PubMedCrossRef
18.
go back to reference O’Brien JR. Platelet aggregation: part II some results from a new method of study. J Clin Pathol. 1962;15:452–5.CrossRef O’Brien JR. Platelet aggregation: part II some results from a new method of study. J Clin Pathol. 1962;15:452–5.CrossRef
20.
go back to reference Schwarz UR, Geiger J, Walter U, Eigenthaler M. Flow cytometry analysis of intracellular VASP phosphorylation for the assessment of activating and inhibitory signal transduction pathways in human platelets--definition and detection of ticlopidine/clopidogrel effects. Thromb Haemost. 1999;82:1145–52.PubMedCrossRef Schwarz UR, Geiger J, Walter U, Eigenthaler M. Flow cytometry analysis of intracellular VASP phosphorylation for the assessment of activating and inhibitory signal transduction pathways in human platelets--definition and detection of ticlopidine/clopidogrel effects. Thromb Haemost. 1999;82:1145–52.PubMedCrossRef
21.
go back to reference Chu SG, Becker RC, Berger PB, Bhatt DL, Eikelboom JW, Konkle B, et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost. 2010;8:148–56.PubMedCrossRef Chu SG, Becker RC, Berger PB, Bhatt DL, Eikelboom JW, Konkle B, et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost. 2010;8:148–56.PubMedCrossRef
22.
go back to reference Jakl M, Sevcik R, Ceral J, Fatorova I, Horacek JM, Vojacek J. Mean platelet volume and platelet count: overlooked markers of high on-treatment platelet reactivity and worse outcome in patients with acute coronary syndrome. Anadolu Kardiyol Derg. 2014;14:85–6.PubMed Jakl M, Sevcik R, Ceral J, Fatorova I, Horacek JM, Vojacek J. Mean platelet volume and platelet count: overlooked markers of high on-treatment platelet reactivity and worse outcome in patients with acute coronary syndrome. Anadolu Kardiyol Derg. 2014;14:85–6.PubMed
23.
go back to reference Beyan C, Kaptan K, Ifran A. Platelet count, mean platelet volume, platelet distribution width, and plateletcrit do not correlate with optical platelet aggregation responses in healthy volunteers. J Thromb Thrombolysis. 2006;22:161–4.PubMedCrossRef Beyan C, Kaptan K, Ifran A. Platelet count, mean platelet volume, platelet distribution width, and plateletcrit do not correlate with optical platelet aggregation responses in healthy volunteers. J Thromb Thrombolysis. 2006;22:161–4.PubMedCrossRef
24.
go back to reference Verdoia M, Pergolini P, Rolla R, Nardin M, Barbieri L, Schaffer A, et al. Mean platelet volume and high-residual platelet reactivity in patients receiving dual antiplatelet therapy with clopidogrel or ticagrelor. Expert Opin Pharmacother. 2015;16:1739–47.PubMedCrossRef Verdoia M, Pergolini P, Rolla R, Nardin M, Barbieri L, Schaffer A, et al. Mean platelet volume and high-residual platelet reactivity in patients receiving dual antiplatelet therapy with clopidogrel or ticagrelor. Expert Opin Pharmacother. 2015;16:1739–47.PubMedCrossRef
25.
go back to reference Valgimigli M, Bueno H, Byrne RA, Collet JP, Costa F, Jeppsson A, et al. 2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS: the task force for dual antiplatelet therapy in coronary artery disease of the European Society of Cardiology (ESC) and of the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2018;39:213–60.PubMedCrossRef Valgimigli M, Bueno H, Byrne RA, Collet JP, Costa F, Jeppsson A, et al. 2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS: the task force for dual antiplatelet therapy in coronary artery disease of the European Society of Cardiology (ESC) and of the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2018;39:213–60.PubMedCrossRef
26.
go back to reference Kim IS, Jeong YH, Kang MK, Koh JS, Park Y, Hwang SJ, et al. Correlation of high post-treatment platelet reactivity assessed by light transmittance aggregometry and the VerifyNow P2Y12 assay. J Thromb Thrombolysis. 2010;30:486–95.PubMedCrossRef Kim IS, Jeong YH, Kang MK, Koh JS, Park Y, Hwang SJ, et al. Correlation of high post-treatment platelet reactivity assessed by light transmittance aggregometry and the VerifyNow P2Y12 assay. J Thromb Thrombolysis. 2010;30:486–95.PubMedCrossRef
27.
go back to reference Cattaneo M, Cerletti C, Harrison P, Hayward CP, Kenny D, Nugent D, et al. Recommendations for the standardization of light transmission Aggregometry: a consensus of the working party from the platelet physiology subcommittee of SSC/ISTH. J Thromb Haemost. 2013;11:1183–9.CrossRef Cattaneo M, Cerletti C, Harrison P, Hayward CP, Kenny D, Nugent D, et al. Recommendations for the standardization of light transmission Aggregometry: a consensus of the working party from the platelet physiology subcommittee of SSC/ISTH. J Thromb Haemost. 2013;11:1183–9.CrossRef
28.
go back to reference Barragan P, Bouvier JL, Roquebert PO, Macaluso G, Commeau P, Comet B, et al. Resistance to thienopyridines: clinical detection of coronary stent thrombosis by monitoring of vasodilator-stimulated phosphoprotein phosphorylation. Catheter Cardiovasc Interv. 2003;59:295–302.PubMedCrossRef Barragan P, Bouvier JL, Roquebert PO, Macaluso G, Commeau P, Comet B, et al. Resistance to thienopyridines: clinical detection of coronary stent thrombosis by monitoring of vasodilator-stimulated phosphoprotein phosphorylation. Catheter Cardiovasc Interv. 2003;59:295–302.PubMedCrossRef
29.
go back to reference Marcucci R, Gori AM, Paniccia R, Giusti B, Valente S, Giglioli C, et al. High on-treatment platelet reactivity by more than one agonist predicts 12-month follow-up cardiovascular death and non-fatal myocardial infarction in acute coronary syndrome patients receiving coronary stenting. Thromb Haemost. 2010;104:279–86.PubMedCrossRef Marcucci R, Gori AM, Paniccia R, Giusti B, Valente S, Giglioli C, et al. High on-treatment platelet reactivity by more than one agonist predicts 12-month follow-up cardiovascular death and non-fatal myocardial infarction in acute coronary syndrome patients receiving coronary stenting. Thromb Haemost. 2010;104:279–86.PubMedCrossRef
30.
go back to reference Dehghani P, Lavoie A, Lavi S, Crawford JJ, Harenberg S, Zimmermann RH, et al. Effects of ticagrelor versus clopidogrel on platelet function in fibrinolytic-treated STEMI patients undergoing early PCI. Am Heart J. 2017;192:105–12.PubMedCrossRef Dehghani P, Lavoie A, Lavi S, Crawford JJ, Harenberg S, Zimmermann RH, et al. Effects of ticagrelor versus clopidogrel on platelet function in fibrinolytic-treated STEMI patients undergoing early PCI. Am Heart J. 2017;192:105–12.PubMedCrossRef
31.
go back to reference Wallentin L, Becker RC, Budaj A, Cannon CP, Emanuelsson H, Held C, et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2009;361:1045–57.PubMedCrossRef Wallentin L, Becker RC, Budaj A, Cannon CP, Emanuelsson H, Held C, et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2009;361:1045–57.PubMedCrossRef
32.
go back to reference Held C, Asenblad N, Bassand JP, Becker RC, Cannon CP, Claeys MJ, et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes undergoing coronary artery bypass surgery: results from the PLATO (platelet inhibition and patient outcomes) trial. J Am Coll Cardiol. 2011;57:672–84.PubMedCrossRef Held C, Asenblad N, Bassand JP, Becker RC, Cannon CP, Claeys MJ, et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes undergoing coronary artery bypass surgery: results from the PLATO (platelet inhibition and patient outcomes) trial. J Am Coll Cardiol. 2011;57:672–84.PubMedCrossRef
33.
go back to reference Kang HJ, Clare RM, Gao R, Held C, Himmelmann A, James SK, et al. Ticagrelor versus clopidogrel in Asian patients with acute coronary syndrome: a retrospective analysis from the platelet inhibition and patient outcomes (PLATO) trial. Am Heart J. 2015;169:899–905.e891.PubMedCrossRef Kang HJ, Clare RM, Gao R, Held C, Himmelmann A, James SK, et al. Ticagrelor versus clopidogrel in Asian patients with acute coronary syndrome: a retrospective analysis from the platelet inhibition and patient outcomes (PLATO) trial. Am Heart J. 2015;169:899–905.e891.PubMedCrossRef
34.
go back to reference Li H, Butler K, Yang L, Yang Z, Teng R. Pharmacokinetics and tolerability of single and multiple doses of ticagrelor in healthy Chinese subjects: an open-label, sequential, two-cohort, single-Centre study. Clin Drug Investig. 2012;32:87–97.PubMedCrossRef Li H, Butler K, Yang L, Yang Z, Teng R. Pharmacokinetics and tolerability of single and multiple doses of ticagrelor in healthy Chinese subjects: an open-label, sequential, two-cohort, single-Centre study. Clin Drug Investig. 2012;32:87–97.PubMedCrossRef
35.
go back to reference Wang Y, Wu H, Chen Y, Wang Q, Qian J, Ge J. Ticagrelor pharmacokinetics and pharmacodynamics in Chinese patients with STEMI and NSTEMI without opioid administration. Adv Ther. 2020;37:4220–32.PubMedCrossRef Wang Y, Wu H, Chen Y, Wang Q, Qian J, Ge J. Ticagrelor pharmacokinetics and pharmacodynamics in Chinese patients with STEMI and NSTEMI without opioid administration. Adv Ther. 2020;37:4220–32.PubMedCrossRef
36.
go back to reference Tang XF, Han YL, Zhang JH, Wang J, Zhang Y, Xu B, et al. Comparing of light transmittance aggregometry and modified thrombelastograph in predicting clinical outcomes in Chinese patients undergoing coronary stenting with clopidogrel. Chin Med J. 2015;128:774–9.PubMedPubMedCentralCrossRef Tang XF, Han YL, Zhang JH, Wang J, Zhang Y, Xu B, et al. Comparing of light transmittance aggregometry and modified thrombelastograph in predicting clinical outcomes in Chinese patients undergoing coronary stenting with clopidogrel. Chin Med J. 2015;128:774–9.PubMedPubMedCentralCrossRef
37.
go back to reference Liu Z, Tian R, Wang Y, Chen Q, Li J, Xu L, et al. Platelet inhibition with Ticagrelor versus Clopidogrel in diabetic patients after percutaneous coronary intervention for chronic coronary syndromes. Thromb Haemost. 2020;120:1221–9.PubMedCrossRef Liu Z, Tian R, Wang Y, Chen Q, Li J, Xu L, et al. Platelet inhibition with Ticagrelor versus Clopidogrel in diabetic patients after percutaneous coronary intervention for chronic coronary syndromes. Thromb Haemost. 2020;120:1221–9.PubMedCrossRef
38.
go back to reference Spurgeon BE, Aburima A, Oberprieler NG, Tasken K, Naseem KM. Multiplexed phosphospecific flow cytometry enables large-scale signaling profiling and drug screening in blood platelets. J Thromb Haemost. 2014;12:1733–43.PubMedCrossRef Spurgeon BE, Aburima A, Oberprieler NG, Tasken K, Naseem KM. Multiplexed phosphospecific flow cytometry enables large-scale signaling profiling and drug screening in blood platelets. J Thromb Haemost. 2014;12:1733–43.PubMedCrossRef
39.
go back to reference Valenti R, Marcucci R, Capodanno D, De Luca G, Migliorini A, Gori AM, et al. Residual platelet reactivity to predict long-term clinical outcomes after clopidogrel loading in patients with acute coronary syndromes: comparison of different cutoff values by light transmission aggregometry from the responsiveness to clopidogrel and stent thrombosis 2-acute coronary syndrome (RECLOSE 2-ACS) study. J Thromb Thrombolysis. 2015;40:76–82.PubMedCrossRef Valenti R, Marcucci R, Capodanno D, De Luca G, Migliorini A, Gori AM, et al. Residual platelet reactivity to predict long-term clinical outcomes after clopidogrel loading in patients with acute coronary syndromes: comparison of different cutoff values by light transmission aggregometry from the responsiveness to clopidogrel and stent thrombosis 2-acute coronary syndrome (RECLOSE 2-ACS) study. J Thromb Thrombolysis. 2015;40:76–82.PubMedCrossRef
40.
go back to reference Tantry US, Bonello L, Aradi D, Price MJ, Jeong YH, Angiolillo DJ, et al. Consensus and update on the definition of on-treatment platelet reactivity to adenosine diphosphate associated with ischemia and bleeding. J Am Coll Cardiol. 2013;62:2261–73.PubMedCrossRef Tantry US, Bonello L, Aradi D, Price MJ, Jeong YH, Angiolillo DJ, et al. Consensus and update on the definition of on-treatment platelet reactivity to adenosine diphosphate associated with ischemia and bleeding. J Am Coll Cardiol. 2013;62:2261–73.PubMedCrossRef
41.
go back to reference Aradi D, Kirtane A, Bonello L, Gurbel PA, Tantry US, Huber K, et al. Bleeding and stent thrombosis on P2Y12-inhibitors: collaborative analysis on the role of platelet reactivity for risk stratification after percutaneous coronary intervention. Eur Heart J. 2015;36:1762–71.PubMedCrossRef Aradi D, Kirtane A, Bonello L, Gurbel PA, Tantry US, Huber K, et al. Bleeding and stent thrombosis on P2Y12-inhibitors: collaborative analysis on the role of platelet reactivity for risk stratification after percutaneous coronary intervention. Eur Heart J. 2015;36:1762–71.PubMedCrossRef
42.
go back to reference Jeong YH, Tantry US, Kim IS, Koh JS, Kwon TJ, Park Y, et al. Effect of CYP2C19*2 and *3 loss-of-function alleles on platelet reactivity and adverse clinical events in east Asian acute myocardial infarction survivors treated with clopidogrel and aspirin. Circ Cardiovasc Interv. 2011;4:585–94.PubMedCrossRef Jeong YH, Tantry US, Kim IS, Koh JS, Kwon TJ, Park Y, et al. Effect of CYP2C19*2 and *3 loss-of-function alleles on platelet reactivity and adverse clinical events in east Asian acute myocardial infarction survivors treated with clopidogrel and aspirin. Circ Cardiovasc Interv. 2011;4:585–94.PubMedCrossRef
43.
go back to reference Li S, Choi JL, Guo LZ, Goh RY, Kim BR, Woo KS, et al. Correlation between the CYP2C19 phenotype status and the results of three different platelet function tests in cardiovascular disease patients receiving antiplatelet therapy: an emphasis on newly introduced platelet function analyzer-200 P2Y test. Ann Lab Med. 2016;36:42–8.PubMedCrossRef Li S, Choi JL, Guo LZ, Goh RY, Kim BR, Woo KS, et al. Correlation between the CYP2C19 phenotype status and the results of three different platelet function tests in cardiovascular disease patients receiving antiplatelet therapy: an emphasis on newly introduced platelet function analyzer-200 P2Y test. Ann Lab Med. 2016;36:42–8.PubMedCrossRef
44.
go back to reference Man M, Farmen M, Dumaual C, Teng CH, Moser B, Irie S, et al. Genetic variation in metabolizing enzyme and transporter genes: comprehensive assessment in 3 major east Asian subpopulations with comparison to Caucasians and Africans. J Clin Pharmacol. 2010;50:929–40.PubMedCrossRef Man M, Farmen M, Dumaual C, Teng CH, Moser B, Irie S, et al. Genetic variation in metabolizing enzyme and transporter genes: comprehensive assessment in 3 major east Asian subpopulations with comparison to Caucasians and Africans. J Clin Pharmacol. 2010;50:929–40.PubMedCrossRef
45.
go back to reference Wang Z, Liu Z, Wang W, Fu Y, Chen W, Li W, et al. Two common mutations within CYP2C19 affected platelet aggregation in Chinese patients undergoing PCI: a one-year follow-up study. Pharmacogenomics J. 2019;19:157–63.PubMedCrossRef Wang Z, Liu Z, Wang W, Fu Y, Chen W, Li W, et al. Two common mutations within CYP2C19 affected platelet aggregation in Chinese patients undergoing PCI: a one-year follow-up study. Pharmacogenomics J. 2019;19:157–63.PubMedCrossRef
46.
go back to reference Narasimhalu K, Ang YK, Tan DSY, De Silva DA, Tan KB. Cost effectiveness of genotype-guided antiplatelet therapy in Asian ischemic stroke patients: Ticagrelor as an alternative to Clopidogrel in patients with CYP2C19 loss of function mutations. Clin Drug Investig. 2020;40:1063–70.PubMedCrossRef Narasimhalu K, Ang YK, Tan DSY, De Silva DA, Tan KB. Cost effectiveness of genotype-guided antiplatelet therapy in Asian ischemic stroke patients: Ticagrelor as an alternative to Clopidogrel in patients with CYP2C19 loss of function mutations. Clin Drug Investig. 2020;40:1063–70.PubMedCrossRef
47.
go back to reference Nadar SK, Blann AD, Kamath S, Beevers DG, Lip GY. Platelet indexes in relation to target organ damage in high-risk hypertensive patients: a substudy of the Anglo-Scandinavian cardiac outcomes trial (ASCOT). J Am Coll Cardiol. 2004;44:415–22.PubMedCrossRef Nadar SK, Blann AD, Kamath S, Beevers DG, Lip GY. Platelet indexes in relation to target organ damage in high-risk hypertensive patients: a substudy of the Anglo-Scandinavian cardiac outcomes trial (ASCOT). J Am Coll Cardiol. 2004;44:415–22.PubMedCrossRef
48.
go back to reference Ozder A, Eker HH. Investigation of mean platelet volume in patients with type 2 diabetes mellitus and in subjects with impaired fasting glucose: a cost-effective tool in primary health care? Int J Clin Exp Med. 2014;7:2292–7.PubMedPubMedCentral Ozder A, Eker HH. Investigation of mean platelet volume in patients with type 2 diabetes mellitus and in subjects with impaired fasting glucose: a cost-effective tool in primary health care? Int J Clin Exp Med. 2014;7:2292–7.PubMedPubMedCentral
49.
go back to reference Lippi G, Meschi T, Borghi L. Mean platelet volume increases with aging in a large population study. Thromb Res. 2012;129:e159–60.PubMedCrossRef Lippi G, Meschi T, Borghi L. Mean platelet volume increases with aging in a large population study. Thromb Res. 2012;129:e159–60.PubMedCrossRef
50.
go back to reference Huczek Z, Kochman J, Filipiak KJ, Horszczaruk GJ, Grabowski M, Piatkowski R, et al. Mean platelet volume on admission predicts impaired reperfusion and long-term mortality in acute myocardial infarction treated with primary percutaneous coronary intervention. J Am Coll Cardiol. 2005;46:284–90.PubMedCrossRef Huczek Z, Kochman J, Filipiak KJ, Horszczaruk GJ, Grabowski M, Piatkowski R, et al. Mean platelet volume on admission predicts impaired reperfusion and long-term mortality in acute myocardial infarction treated with primary percutaneous coronary intervention. J Am Coll Cardiol. 2005;46:284–90.PubMedCrossRef
51.
go back to reference Tavil Y, Sen N, Yazici HU, Hizal F, Abaci A, Cengel A. Mean platelet volume in patients with metabolic syndrome and its relationship with coronary artery disease. Thromb Res. 2007;120:245–50.PubMedCrossRef Tavil Y, Sen N, Yazici HU, Hizal F, Abaci A, Cengel A. Mean platelet volume in patients with metabolic syndrome and its relationship with coronary artery disease. Thromb Res. 2007;120:245–50.PubMedCrossRef
52.
go back to reference Asher E, Fefer P, Shechter M, Beigel R, Varon D, Shenkman B, et al. Increased mean platelet volume is associated with non-responsiveness to clopidogrel. Thromb Haemost. 2014;112:137–41.PubMedCrossRef Asher E, Fefer P, Shechter M, Beigel R, Varon D, Shenkman B, et al. Increased mean platelet volume is associated with non-responsiveness to clopidogrel. Thromb Haemost. 2014;112:137–41.PubMedCrossRef
53.
go back to reference Kubica A, Kasprzak M, Siller-Matula J, Kozinski M, Pio Navarese E, Obonska K, et al. Time-related changes in determinants of antiplatelet effect of clopidogrel in patients after myocardial infarction. Eur J Pharmacol. 2014;742:47–54.PubMedCrossRef Kubica A, Kasprzak M, Siller-Matula J, Kozinski M, Pio Navarese E, Obonska K, et al. Time-related changes in determinants of antiplatelet effect of clopidogrel in patients after myocardial infarction. Eur J Pharmacol. 2014;742:47–54.PubMedCrossRef
54.
go back to reference Kim YG, Suh JW, Yoon CH, Oh IY, Cho YS, Youn TJ, et al. Platelet volume indices are associated with high residual platelet reactivity after antiplatelet therapy in patients undergoing percutaneous coronary intervention. J Atheroscler Thromb. 2014;21:445–53.PubMedCrossRef Kim YG, Suh JW, Yoon CH, Oh IY, Cho YS, Youn TJ, et al. Platelet volume indices are associated with high residual platelet reactivity after antiplatelet therapy in patients undergoing percutaneous coronary intervention. J Atheroscler Thromb. 2014;21:445–53.PubMedCrossRef
55.
go back to reference Hardy M, Lessire S, Kasikci S, Baudar J, Guldenpfennig M, Collard A, et al. Effects of time-interval since blood draw and of anticoagulation on platelet testing (count, indices and impedance aggregometry): a systematic study with blood from healthy volunteers. J Clin Med. 2020;9:994–7.CrossRef Hardy M, Lessire S, Kasikci S, Baudar J, Guldenpfennig M, Collard A, et al. Effects of time-interval since blood draw and of anticoagulation on platelet testing (count, indices and impedance aggregometry): a systematic study with blood from healthy volunteers. J Clin Med. 2020;9:994–7.CrossRef
56.
go back to reference Storey RF, Angiolillo DJ, Patil SB, Desai B, Ecob R, Husted S, et al. Inhibitory effects of ticagrelor compared with clopidogrel on platelet function in patients with acute coronary syndromes: the PLATO (PLATelet inhibition and patient outcomes) PLATELET substudy. J Am Coll Cardiol. 2010;56:1456–62.PubMedCrossRef Storey RF, Angiolillo DJ, Patil SB, Desai B, Ecob R, Husted S, et al. Inhibitory effects of ticagrelor compared with clopidogrel on platelet function in patients with acute coronary syndromes: the PLATO (PLATelet inhibition and patient outcomes) PLATELET substudy. J Am Coll Cardiol. 2010;56:1456–62.PubMedCrossRef
57.
go back to reference Jia H, Dai J, Hou J, Xing L, Ma L, Liu H, et al. Effective anti-thrombotic therapy without stenting: intravascular optical coherence tomography-based management in plaque erosion (the EROSION study). Eur Heart J. 2017;38:792–800.PubMed Jia H, Dai J, Hou J, Xing L, Ma L, Liu H, et al. Effective anti-thrombotic therapy without stenting: intravascular optical coherence tomography-based management in plaque erosion (the EROSION study). Eur Heart J. 2017;38:792–800.PubMed
Metadata
Title
Clopidogrel versus ticagrelor in the treatment of Chinese patients undergoing percutaneous coronary intervention: effects on platelet function assessed by platelet function tests and mean platelet volume
Authors
Yang Zhang
Rui Peng
Xiaojuan Li
Gaowa Cheng
Ximing Wang
Jinxing Yu
Muxing Hua
Xi Chen
Zhou Zhou
Publication date
01-12-2021
Publisher
BioMed Central
Published in
Thrombosis Journal / Issue 1/2021
Electronic ISSN: 1477-9560
DOI
https://doi.org/10.1186/s12959-021-00350-2

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