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Open Access 01-10-2016 | Review

Anti-thrombotic agents derived from snake venom proteins

Authors: Tur-Fu Huang, Chun-Chieh Hsu, Yu-Ju Kuo

Published in: Thrombosis Journal | Special Issue 1/2016

Abstract

Snake venoms affect blood coagulation and platelet function in a complex manner. However, two classes of venom proteins, snaclecs and disintegrins have been shown to specifically target receptors including GPIb, α2β1, GPVI, CLEC-2 and integrins αIIbβ3, αvβ3, α5β1 expressed on platelets, endothelial cells, phagocytes, tumor cells, thus affecting cell-matrices and cell-cell interactions. Here, we focus on disintegrins, a class of low molecular mass Arg-Gly-Asp(RGD)/Lys-Gly-Asp(KGD)-containing, cysteine-rich polypeptide derived from various viper snake venoms. This review describes the potential applications of disintegrins in field of integrin-related diseases, especially arterial thrombosis, angiogenesis, tumor progression and septic inflammation. In addition, a novel RGD-containing disintegrin TMV-7 is being developed as a safer antithrombotic agent with minimal side effects, such as thrombocytopenia and bleeding.

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Title: Anti-thrombotic agents derived from snake venom proteins
Authors: Tur-Fu Huang
Chun-Chieh Hsu
Yu-Ju Kuo
Publication date: 01-10-2016
Publisher: BioMed Central
Published in: Thrombosis Journal / Issue Special Issue 1/2016
Electronic ISSN: 1477-9560
DOI: https://doi.org/10.1186/s12959-016-0113-1

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