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Reproductive Biology and Endocrinology
Published in: Reproductive Biology and Endocrinology 1/2020

01-12-2020 | Endometrial Cancer | Review

Histone acetylation and the role of histone deacetylases in normal cyclic endometrium

Authors: Palak Gujral, Vishakha Mahajan, Abbey C. Lissaman, Anna P. Ponnampalam

Published in: Reproductive Biology and Endocrinology | Issue 1/2020

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Abstract

Histone acetylation is a critical epigenetic modification that changes chromatin architecture and regulates gene expression by opening or closing the chromatin structure. It plays an essential role in cell cycle progression and differentiation. The human endometrium goes through cycles of regeneration, proliferation, differentiation, and degradation each month; each phase requiring strict epigenetic regulation for the proper functioning of the endometrium. Aberrant histone acetylation and alterations in levels of two acetylation modulators - histone acetylases (HATs) and histone deacetylases (HDACs) - have been associated with endometrial pathologies such as endometrial cancer, implantation failures, and endometriosis. Thus, histone acetylation is likely to have an essential role in the regulation of endometrial remodelling throughout the menstrual cycle.
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Metadata
Title
Histone acetylation and the role of histone deacetylases in normal cyclic endometrium
Authors
Palak Gujral
Vishakha Mahajan
Abbey C. Lissaman
Anna P. Ponnampalam
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Reproductive Biology and Endocrinology / Issue 1/2020
Electronic ISSN: 1477-7827
DOI
https://doi.org/10.1186/s12958-020-00637-5

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