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Open Access 01-12-2018 | Hypothesis

Navigation problems of ICSI or naive blastocyst can be solved with artificial blastocyst

Authors: Onder Celik, Mustafa Acet, Haldun Arpaci, Levent Dikbas, Aytac Imren, Bulent Duran, Nilufer Celik, Sudenaz Celik, Cihat Unlu, Ibrahim Sahin, Suleyman Aydin

Published in: Reproductive Biology and Endocrinology | Issue 1/2018

Abstract

Embryos have evolved a remarkable capacity to find implantation site. The impressive navigation ability of natural blastocysts may rely on highly sensitive signals arising from embryos and specialized signal processing strategies in the endometrium. Navigation capabilities may be compromised in ICSI embryos because of altered biochemical signaling. The design and delivery of artificial blastocyst (AB) carrying strong chemical signals may allow ICSI embryos to more easily locate to and be retained in the implantation zone. ICSI embryos will attach easily to the implantation zone after it is found by the AB. Co-transfer of the AB together with the ICSI embryo may overcome potential difficulties in implantation due to impaired embryo-maternal communication in cases with implantation failure.

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Title: Navigation problems of ICSI or naive blastocyst can be solved with artificial blastocyst
Authors: Onder Celik
Mustafa Acet
Haldun Arpaci
Levent Dikbas
Aytac Imren
Bulent Duran
Nilufer Celik
Sudenaz Celik
Cihat Unlu
Ibrahim Sahin
Suleyman Aydin
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: Reproductive Biology and Endocrinology / Issue 1/2018
Electronic ISSN: 1477-7827
DOI: https://doi.org/10.1186/s12958-018-0326-1

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Navigation problems of ICSI or naive blastocyst can be solved with artificial blastocyst

Abstract

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Abstract

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