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Reproductive Biology and Endocrinology
Published in: Reproductive Biology and Endocrinology 1/2017

Open Access 01-12-2017 | Review

The myths surrounding mild stimulation in vitro fertilization (IVF)

Authors: Raoul Orvieto, Valeria Stella Vanni, Norbert Gleicher

Published in: Reproductive Biology and Endocrinology | Issue 1/2017

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Abstract

So-called mild controlled ovarian hyperstimulation (mCOH) has in recent years increased in popularity, claiming to be safer and more patient-friendly, while also improving in vitro fertilization (IVF) outcomes. We here challenge the International Society for Mild Approaches in Assisted Reproduction (ISMAAR) definition of mild stimulation, and especially address four fundamental issues, where our review found conventional COH (cCOH) advantageous over mCOH. They are: prevalence of severe ovarian hyperstimulation syndrome (OHSS), oocyte/embryo quality, pregnancy/live birth rates, and cost. We conclude that an objective review of the literature does not support the routine utilization of mCOH in assisted reproduction.
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Metadata
Title
The myths surrounding mild stimulation in vitro fertilization (IVF)
Authors
Raoul Orvieto
Valeria Stella Vanni
Norbert Gleicher
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Reproductive Biology and Endocrinology / Issue 1/2017
Electronic ISSN: 1477-7827
DOI
https://doi.org/10.1186/s12958-017-0266-1

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