Published in:
Open Access 01-12-2015 | Research
Predictive value of the time interval between embryo loading and transfer for IVF/ICSI success: a prospective cohort study
Published in: Reproductive Biology and Endocrinology | Issue 1/2015
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Background
The influence of embryo loading time (ELT) and the time interval between embryo loading and embryo transfer (TIEL-ET) on the success of IVF/ICSI is unknown.
Methods
In a prospective cohort study, we aimed to ascertain the influence of ELT and TIEL-ET on ongoing pregnancy rate (OPR) and life birth rate (LBR). Data from 603 consecutive embryo transfers between January 2008 and December 2013 were collected. A complete data set including the outcomes of interest OPR and LBR was available for 410 women. The primary outcome was IVF/ICSI success, defined as OPR and LBR.
Results
We used univariate and multivariate logistic regression for analysis. In a multivariate analysis, age (odds ratio [OR] 0.94; 95 % confidence interval [CI] 0.89–0.99), catheter type (OR 0.45; 95 % CI 0.24–0.84), and uterine length (OR 1.03; 95 % CI 1.01–1.06), but not ELT and TIELT-ET were independently associated with OPR. Regarding LBR, age (OR 0.93; 95 % CI 0.88–0.98), catheter type (OR 0.41; 95 % CI 0.22–0.79), and uterine length (OR 1.03; 95 % CI 1.01–1.06), but not ELT and TIELT-ET were independent predictors.
Conclusion
We conclude that speed of embryo transfer is not critical for the success of IVF/ICSI. However, care should be taken to choose catheter types proven to be associated with a high success rate.