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World Journal of Surgical Oncology
Published in: World Journal of Surgical Oncology 1/2019

Open Access 01-12-2019 | Rectal Cancer | Research

Factors predicting recurrence after curative resection for rectal cancer: a 16-year study

Authors: Waad Farhat, Mohamed Azzaza, Abdelkader Mizouni, Houssem Ammar, Mahdi ben Ltaifa, Sami Lagha, Mohamed Kahloul, Rahul Gupta, Mohamed Ben Mabrouk, Ali Ben Ali

Published in: World Journal of Surgical Oncology | Issue 1/2019

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Abstract

Background

The recurrence after curative surgery of the rectal adenocarcinoma is a serious complication, considered as a failure of the therapeutic strategy. The aim of this study was to identify the different prognostic factors affecting the recurrence of adenocarcinoma of the rectum.

Methods

A retrospective analysis of patients operated for adenocarcinoma of the rectum between January 2000 and December 2015 was conducted. The study of the recurrence rate and prognostic factors was performed through the Kaplan Meier survival curve and the Cox regression analysis.

Results

During the study period, 188 patients underwent curative surgery for rectal adenocarcinoma, among which 53 had a recurrence. The recurrence rate was 44.6% at 5 years. The multivariate analysis identified four parameters independently associated with the risk of recurrence after curative surgery: a distal margin ≤ 2 cm (HR = 6.8, 95% CI 2.7–16.6, 6), extracapsular invasion of lymph node metastasis (HR = 4.4, 95% CI 1.3–14), tumor stenosis (HR = 4.3, 95% CI 1.2–15.2), and parietal invasion (pT3/T4 disease) (HR = 3, 95% CI 1.1–9.4).

Conclusion

The determination of the prognostic factors affecting the recurrence of rectal adenocarcinoma after curative surgery allows us to define the high-risk patients for recurrence.

Trial registration

ClinicalTrials.gov Identifier: NCT03899870. Registered on 2 February 2019, retrospectively registered.
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Metadata
Title
Factors predicting recurrence after curative resection for rectal cancer: a 16-year study
Authors
Waad Farhat
Mohamed Azzaza
Abdelkader Mizouni
Houssem Ammar
Mahdi ben Ltaifa
Sami Lagha
Mohamed Kahloul
Rahul Gupta
Mohamed Ben Mabrouk
Ali Ben Ali
Publication date
01-12-2019
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2019
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/s12957-019-1718-1

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