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World Journal of Surgical Oncology
Published in: World Journal of Surgical Oncology 1/2019

Open Access 01-12-2019 | Metastasis | Research

Laparoscopic liver resection for non-colorectal non-neuroendocrine metastases: perioperative and oncologic outcomes

Authors: Davit L. Aghayan, Piotr Kalinowski, Airazat M. Kazaryan, Åsmund Avdem Fretland, Mushegh A. Sahakyan, Bård I. Røsok, Egidijus Pelanis, Bjørn Atle Bjørnbeth, Bjørn Edwin

Published in: World Journal of Surgical Oncology | Issue 1/2019

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Abstract

Background

Liver resection is a treatment of choice for colorectal and neuroendocrine liver metastases, and laparoscopy is an accepted approach for surgical treatment of these patients. The role of liver resection for patients with non-colorectal non-neuroendocrine liver metastases (NCNNLM), however, is still disputable. Outcomes of laparoscopic liver resection for this group of patients have not been analyzed.

Material and methods

In this retrospective study, patients who underwent laparoscopic liver resection for NCNNLM at Oslo University Hospital between April 2000 and January 2018 were analyzed. Perioperative and oncologic data of these patients were examined. Postoperative morbidity was classified using the Accordion classification. Kaplan–Meier method was used for survival analysis. Median follow-up was 26 (IQR, 12–41) months.

Results

Fifty-one patients were identified from a prospectively collected database. The histology of primary tumors was classified as adenocarcinoma (n = 16), sarcoma (n = 4), squamous cell carcinoma (n = 4), melanoma (n = 16), gastrointestinal stromal tumor (n = 9), and adrenocortical carcinoma (n = 2). The median operative time was 147 (IQR, 95–225) min, while the median blood loss was 200 (IQR, 50–500) ml. Nine (18%) patients experienced postoperative complications. There was no 90-day mortality in this study. Thirty-five (68%) patients developed disease recurrence or progression. Seven (14%) patients underwent repeat surgical procedure for recurrent liver metastases. One-, three-, and five-year overall survival rates were 85%, 52%, and 38%, respectively. The median overall survival was 37 (95%CI, 25 to 49) months.

Conclusion

Laparoscopic liver resection for NCNNLM results in good outcomes and should be considered in patients selected for surgical treatment.
Literature
1.
Takemura N, Saiura A. Role of surgical resection for non-colorectal non-neuroendocrine liver metastases. W J Hepatol. 2017;9(5):242–51.CrossRef
2.
Rees M, Tekkis PP, Welsh FK, O’Rourke T, John TG. Evaluation of long-term survival after hepatic resection for metastatic colorectal cancer: a multifactorial model of 929 patients. Ann Surg. 2008;247(1):125–35.PubMedCrossRef
3.
Curley SA. Outcomes after surgical treatment of colorectal cancer liver metastases. Semin Oncol. 2005;32(6 Suppl 9):S109–11.PubMedCrossRef
4.
Nordlinger B, Sorbye H, Glimelius B, Poston GJ, Schlag PM, Rougier P, et al. Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, phase 3 trial. Lancet Oncol. 2013;14(12):1208–15.PubMedCrossRef
5.
Pavel M, O'Toole D, Costa F, Capdevila J, Gross D, Kianmanesh R, et al. ENETS Consensus Guidelines Update for the Management of Distant Metastatic Disease of Intestinal, Pancreatic, Bronchial Neuroendocrine Neoplasms (NEN) and NEN of Unknown Primary Site. Neuroendocrinology. 2016;103(2):172–85.PubMedCrossRef
6.
Harrison LE, Brennan MF, Newman E, Fortner JG, Picardo A, Blumgart LH, et al. Hepatic resection for noncolorectal, nonneuroendocrine metastases: a fifteen-year experience with ninety-six patients. Surgery. 1997;121(6):625–32.PubMedCrossRef
7.
Adam R, Chiche L, Aloia T, Elias D, Salmon R, Rivoire M, et al. Hepatic resection for noncolorectal nonendocrine liver metastases: analysis of 1,452 patients and development of a prognostic model. Ann Surg. 2006;244(4):524–35.PubMedPubMedCentral
8.
Sim DPY, Goh BKP, Lee SY, Chan CY, Tan IBH, Cheow PC, et al. Preoperative prognostic factors after liver resection for non-colorectal, non-neuroendocrine liver metastases and validation of the Adam Score in an Asian population. World J Surg. 2018;42(4):1073–84.PubMedCrossRef
9.
Edwin B, Mala T, Gladhaug I, Fosse E, Mathisen Y, Bergan A, et al. Liver tumors and minimally invasive surgery: a feasibility study. J Laparoendosc Adv Surg Tech A. 2001;11(3):133–9.PubMedCrossRef
10.
Mala T, Edwin B, Rosseland AR, Gladhaug I, Fosse E, Mathisen O. Laparoscopic liver resection: experience of 53 procedures at a single center. J Hepatobiliary Pancreat Surg. 2005;12(4):298–303.PubMedCrossRef
11.
Kazaryan AM, Pavlik Marangos I, Rosseland AR, Rosok BI, Mala T, Villanger O, et al. Laparoscopic liver resection for malignant and benign lesions: ten-year Norwegian single-center experience. Arch Surg. 2010;145(1):34–40.PubMedCrossRef
12.
Fretland AA, Dagenborg VJ, Bjornelv GMW, Kazaryan AM, Kristiansen R, Fagerland MW, et al. Laparoscopic versus open resection for colorectal liver metastases: The OSLO-COMET Randomized Controlled Trial. Ann Surg. 2018;267(2):199–207.PubMedCrossRef
13.
Aghayan DL, Pelanis E, Avdem Fretland A, Kazaryan AM, Sahakyan MA, Rosok BI, et al. Laparoscopic parenchyma-sparing liver resection for colorectal metastases. Radiol Oncol. 2018;52(1):36–41.PubMedCrossRef
14.
Strasberg SM, Linehan DC, Hawkins WG. The accordion severity grading system of surgical complications. Ann Surg. 2009;250(2):177–86.PubMedCrossRef
15.
Porembka MR, Hall BL, Hirbe M, Strasberg SM. Quantitative weighting of postoperative complications based on the accordion severity grading system: demonstration of potential impact using the american college of surgeons national surgical quality improvement program. J Am Coll Surg. 2010;210(3):286–98.PubMedCrossRef
16.
Moris D, Ronnekleiv-Kelly S, Rahnemai-Azar AA, Felekouras E, Dillhoff M, Schmidt C, et al. Parenchymal-sparing versus anatomic liver resection for colorectal liver metastases: a systematic review. J Gastrointest Surg. 2017;21(6):1076–85.PubMedCrossRef
17.
Cipriani F, Rawashdeh M, Ahmed M, Armstrong T, Pearce NW, Abu Hilal M. Oncological outcomes of laparoscopic surgery of liver metastases: a single-centre experience. Updates Surg. 2015;67(2):185–91.PubMedCrossRef
18.
Kandil E, Noureldine SI, Koffron A, Yao L, Saggi B, Buell JF. Outcomes of laparoscopic and open resection for neuroendocrine liver metastases. Surgery. 2012;152(6):1225–31.PubMedCrossRef
19.
Saxena A, Chua TC, Perera M, Chu F, Morris DL. Surgical resection of hepatic metastases from neuroendocrine neoplasms: a systematic review. Surg Oncol. 2012;21(3):e131–41.PubMedCrossRef
20.
Fitzgerald TL, Brinkley J, Banks S, Vohra N, Englert ZP, Zervos EE. The benefits of liver resection for non-colorectal, non-neuroendocrine liver metastases: a systematic review. Langenbecks Arch Surg. 2014;399(8):989–1000.PubMedCrossRef
21.
Labgaa I, Slankamenac K, Schadde E, Jibara G, Alshebeeb K, Mentha G, et al. Liver resection for metastases not of colorectal, neuroendocrine, sarcomatous, or ovarian (NCNSO) origin: a multicentric study. Am J Surg. 2018;215(1):125–30.PubMedCrossRef
22.
Berardi G, Van Cleven S, Fretland AA, Barkhatov L, Halls M, Cipriani F, et al. Evolution of laparoscopic liver surgery from innovation to implementation to mastery: perioperative and oncologic outcomes of 2,238 patients from 4 European specialized centers. J Am Coll Surg. 2017;225(5):639–49.PubMedCrossRef
23.
Groeschl RT, Nachmany I, Steel JL, Reddy SK, Glazer ES, de Jong MC, et al. Hepatectomy for noncolorectal non-neuroendocrine metastatic cancer: a multi-institutional analysis. J Am Coll Surg. 2012;214(5):769–77.PubMedCrossRef
24.
Gigot JF, Glineur D, Santiago Azagra J, Goergen M, Ceuterick M, Morino M, et al. Laparoscopic liver resection for malignant liver tumors: preliminary results of a multicenter European study. Ann Surg. 2002;236(1):90–7.PubMedPubMedCentralCrossRef
25.
Fretland AA, Dagenborg VJ, Bjornelv GMW, Kazaryan AM, Kristiansen R, Fagerland MW, et al. Laparoscopic versus open resection for colorectal liver metastases: the OSLO-COMET Randomized Controlled Trial. Ann Surg. 2017.
26.
Goh EL, Chidambaram S, Ma S. Laparoscopic vs open hepatectomy for hepatocellular carcinoma in patients with cirrhosis: a meta-analysis of the long-term survival outcomes. Int J Surg. 2018;50:35–42.PubMedCrossRef
27.
Guro H, Kim JW, Choi Y, Cho JY, Yoon YS, Han HS. Multidisciplinary management of intrahepatic cholangiocarcinoma: current approaches. Surg Oncol. 2017;26(2):146–52.PubMedCrossRef
28.
Sano K, Yamamoto M, Mimura T, Endo I, Nakamori S, Konishi M, et al. Outcomes of 1,639 hepatectomies for non-colorectal non-neuroendocrine liver metastases: a multicenter analysis. J Hepatobiliary Pancreat Sci. 2018;25(11):465–75.PubMedCrossRef
29.
Sim DPY, Goh BKP, Lee SY, Chan CY, Tan IBH, Cheow PC, et al. Preoperative prognostic factors after liver resection for non-colorectal, non-neuroendocrine liver metastases and validation of the Adam Score in an Asian population. World J Surg. 2017.
30.
Maeda Y, Shinohara T, Katayama T, Futakawa N, Hamada T. Hepatectomy for liver metastases in non-colorectal, non-neuroendocrine cancer patients. The survival benefit in primary unresectable cases. Int J Surg. 2015;22:136–42.PubMedCrossRef
31.
Clarke NAR, Kanhere HA, Trochsler MI, Maddern GJ. Liver resection for non-colorectal non-neuroendocrine metastases. ANZ J Surg. 2018;88(4):E313–e7.PubMedCrossRef
32.
Aghayan DL, Kazaryan AM, Fretland AA, Sahakyan MA, Rosok BI, Bjornbeth BA, et al. Laparoscopic liver resection for metastatic melanoma. Surg Endosc. 2018;32(3):1470–7.PubMedCrossRef
33.
Edwin B, Nordin A, Kazaryan AM. Laparoscopic liver surgery: new frontiers. Scand J Surg. 2011;100(1):54–65.PubMedCrossRef
34.
Postriganova N, Kazaryan AM, Rosok BI, Fretland A, Barkhatov L, Edwin B. Margin status after laparoscopic resection of colorectal liver metastases: does a narrow resection margin have an influence on survival and local recurrence? HPB (Oxford). 2014;16(9):822–9.PubMedCrossRef
35.
Moris D, Dimitroulis D, Vernadakis S, Papalampros A, Spartalis E, Petrou A, et al. Parenchymal-sparing hepatectomy as the new doctrine in the treatment of liver-metastatic colorectal disease: beyond oncological outcomes. Anticancer Res. 2017;37(1):9–14.PubMedCrossRef
36.
Evrard S, Poston G, Kissmeyer-Nielsen P, Diallo A, Desolneux G, Brouste V, et al. Combined ablation and resection (CARe) as an effective parenchymal sparing treatment for extensive colorectal liver metastases. PloS One. 2014;9(12):e114404.PubMedPubMedCentralCrossRef
37.
Hoffmann K, Bulut S, Tekbas A, Hinz U, Buchler MW, Schemmer P. Is hepatic resection for non-colorectal, non-neuroendocrine liver metastases justified? Ann Surg Oncol. 2015;22(Suppl 3):S1083–92.PubMedCrossRef
38.
Lendoire J, Moro M, Andriani O, Grondona J, Gil O, Raffin G, et al. Liver resection for non-colorectal, non-neuroendocrine metastases: analysis of a multicenter study from Argentina. HPB (Oxford). 2007;9(6):435–9.PubMedPubMedCentralCrossRef
39.
Uggeri F, Pinotti E, Sandini M, Nespoli L, Gianotti L, Romano F. Prognostic factors affecting long-term survival after resection for noncolorectal, nonneuroendocrine, and nonsarcoma liver metastases. Gastroenterol Res Pract. 2017;2017:5184146.PubMedPubMedCentralCrossRef
40.
Marudanayagam R, Sandhu B, Perera MT, Taniere P, Coldham C, Bramhall S, et al. Hepatic resection for non-colorectal, non-neuroendocrine, non-sarcoma metastasis: a single-centre experience. HPB (Oxford). 2011;13(4):286–92.PubMedPubMedCentralCrossRef
41.
Brudvik KW, Patel SH, Roland CL, Conrad C, Torres KE, Hunt KK, et al. Survival after resection of gastrointestinal stromal tumor and sarcoma liver metastases in 146 patients. J Gastrointest Surg. 2015;19(8):1476–83.PubMedPubMedCentralCrossRef
42.
Turley RS, Peng PD, Reddy SK, Barbas AS, Geller DA, Marsh JW, et al. Hepatic resection for metastatic gastrointestinal stromal tumors in the tyrosine kinase inhibitor era. Cancer. 2012;118(14):3571–8.PubMedCrossRef
43.
Schiergens TS, Luning J, Renz BW, Thomas M, Pratschke S, Feng H, et al. Liver resection for non-colorectal non-neuroendocrine metastases: where do we stand today compared to colorectal cancer? J Gastrointest Surg. 2016;20(6):1163–72.PubMedCrossRef
44.
Gandy RC, Bergamin PA, Haghighi KS. Hepatic resection of non-colorectal non-endocrine liver metastases. ANZ journal of surgery. 2017;87(10):810–4.PubMedCrossRef
45.
Brudvik KW, Jones RP, Giuliante F, Shindoh J, Passot G, Chung MH, et al. RAS mutation clinical risk score to predict survival after resection of colorectal liver metastases. Ann Surg. 2019;269(1):120–6.PubMedCrossRef
46.
Brudvik KW, Vauthey JN. Surgery: KRAS mutations and hepatic recurrence after treatment of colorectal liver metastases. Nat Rev Gastroenterol Hepatol. 2017;14(11):638–9.PubMedCrossRef
47.
Ruiz A, van Hillegersberg R, Siesling S, Castro-Benitez C, Sebagh M, Wicherts DA, et al. Surgical resection versus systemic therapy for breast cancer liver metastases: results of a European case matched comparison. Eur J Cancer. 2018;95:1–10.PubMedCrossRef
Metadata
Title
Laparoscopic liver resection for non-colorectal non-neuroendocrine metastases: perioperative and oncologic outcomes
Authors
Davit L. Aghayan
Piotr Kalinowski
Airazat M. Kazaryan
Åsmund Avdem Fretland
Mushegh A. Sahakyan
Bård I. Røsok
Egidijus Pelanis
Bjørn Atle Bjørnbeth
Bjørn Edwin
Publication date
01-12-2019
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2019
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/s12957-019-1700-y

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