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World Journal of Surgical Oncology

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Open Access 01-12-2019 | Colorectal Cancer | Research

Tumor budding for predicting prognosis of resected rectum cancer after neoadjuvant treatment

Authors: Atakan Demir, Ozkan Alan, Ertugrul Oruc

Published in: World Journal of Surgical Oncology | Issue 1/2019

Abstract

Background

Rectum cancer is a type of colorectal cancer. Its etiology and etiopathogenesis are similar to other colon diseases. We aimed to evaluate the tumor budding for predicting prognosis of resected rectum cancer patients.

Methods

We retrospectively collected the data of 75 operated rectum adenocarcinoma patients who were treated neoadjuvant chemoradiotherapy between 2013 and 2018 in Umraniye Research and Training Hospital and Acıbadem University Medical Oncology Outpatient Clinic. Tumor budding was investigated as a prognostic factor for disease-free survival.

Results

This study included 75 rectum cancer patients and 51 were male (68%). Median age was 56 (range 19 to 77 years). There were 29 (39%) and 46 (61%) patients in tumor budding low-intermediate and high groups respectively. In multivariate analysis, tumor budding was found to be an independent prognostic factor for disease-free survival (p = 0.00).

Conclusions

According to our study, having high tumor budding suggests a high likelihood of relapse. Therefore, we might need additional follow-up protocol in these patients.

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Title: Tumor budding for predicting prognosis of resected rectum cancer after neoadjuvant treatment
Authors: Atakan Demir
Ozkan Alan
Ertugrul Oruc
Publication date: 01-12-2019
Publisher: BioMed Central
Keywords: Colorectal Cancer
Colorectal Cancer
Published in: World Journal of Surgical Oncology / Issue 1/2019
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/s12957-019-1588-6

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Tumor budding for predicting prognosis of resected rectum cancer after neoadjuvant treatment

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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