Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
World Journal of Surgical Oncology
Published in: World Journal of Surgical Oncology 1/2017

Open Access 01-12-2017 | Case Report

A distal ileum malignant peripheral nerve sheath tumor causing intussusception in a patient in China: a case report

Authors: Lin-Bo Zhu, Peng-Fei Li, Wei-Hua Xiao, Peng-Bin Zhang, Jun-Qiang Li, Ming-Fei Sun

Published in: World Journal of Surgical Oncology | Issue 1/2017

Login to get access

Abstract

Background

Malignant peripheral nerve sheath tumors (MPNSTs) arise from a peripheral nerve or display nerve sheath differentiation. Most MPNSTs typically originate on the trunk, extremities, head, neck, and paravertebral regions. Gastrointestinal MPNSTs are rare entities with only 10 cases reported worldwide in the literatures.

Case presentation

Here, we report the first Chinese case of a malignant peripheral nerve sheath tumor of the distal ileum presenting as intussusception. A 53-year-old female patient without pathological antecedent for neurofibromatosis was admitted with pain in the right lower abdomen and multiple episodes of vomiting for 1 week. Preoperative diagnosis was intussusception with a contrast-enhanced computed tomography scan (CECT) of the abdomen showing characteristic target sign. Due to difficulty reducing the ileum-colon intussusception, right hemicolectomy with ileocolostomy was performed. Histopathology was suggestive of low-grade MPNST. The patient received postoperative care and was followed up for 9 months. There is no sign of tumor recurrence and metastatic disease.

Conclusions

This case is unique in terms of a rare tumor presenting with unusual complication.
Literature
1.
Grobmyer SR, Reith JD, Shahlaee A, et al. Malignant peripheral nerve sheath tumor: molecular pathogenesis and current management considerations. J Surg Oncol. 2008;97(4):340–9.CrossRefPubMed
2.
Fuchs B, Spinner RJ, Rock MG. Malignant peripheral nerve sheath tumors: an update. J Surg Orthop Adv. 2005;14(4):168–74.PubMed
3.
Ducatman BS, Scheithauer BW, Piepgras DG, et al. Malignant peripheral nerve sheath tumors. A clinicopathologic study of 120 cases. Cancer. 1986;57(10):2006–21.CrossRefPubMed
4.
5.
Tucker T, Wolkenstein P, Revuz J, et al. Association between benign and malignant peripheral nerve sheath tumors in NF1. Neurology. 2005;65(2):205–11.CrossRefPubMed
6.
Zou C, Smith KD, Liu J, et al. Clinical, pathological, and molecular variables predictive of malignant peripheral nerve sheath tumor outcome. Ann Surg. 2009;249(6):1014–22.CrossRefPubMed
7.
Anghileri M, Miceli R, Fiore M, et al. Malignant peripheral nerve sheath tumors: prognostic factors and survival in a series of patients treated at a single institution. Cancer. 2006;107(5):1065–74.CrossRefPubMed
8.
Yilmaz F, Uzunlar AK, Bukte Y. Recurrent malignant schwannoma of the small bowel. Acta Med Austriaca. 2004;31:58–60.PubMed
9.
Eskelinen M, Pasanen P, Kosma VM, et al. Primary malignant schwannoma of the small bowel. Ann Chir Gynaecol. 1992;3:326–8.
10.
Telem DA, Pertsemlidis D. Malignant peripheral nerve sheath tumor: an unusual cause of intussusception. J Gastrointest Surg. 2008;12:1609–11.CrossRefPubMed
11.
Mohtaram A, Mesmoudi S, Hind Mrabti H, et al. Malignant peripheral nerve sheath tumor of the small bowel: an unusual presentation with fatal outcome. Case Rep Oncol Med. 2013;2013:423867.PubMedPubMedCentral
12.
Benz MR, Czernin J, Dry SM, et al. Quantitative F18-fluorodeoxyglucose positron emission tomography accurately characterizes peripheral nerve sheath tumors as malignant or benign. Cancer. 2010;116(2):451–8.CrossRefPubMedPubMedCentral
13.
Shurell E, Eilber FC. Peripheral nerve sheath tumors: diagnosis using quantitative FDG-PET. In: Hayat MA, editor. Tumors of the central nervous system. New York: Springer; 2012. p. 161–6.
14.
Mautner VF, Friedrich RE, von Deimling A, et al. Malignant peripheral nerve sheath tumours in neurofibromatosis type 1: MRI supports the diagnosis of malignant plexiform neurofibroma. Neuroradiology. 2003;45(9):618–25.CrossRefPubMed
15.
Benz MR, Tchekmedyian N, Eilber FC, et al. Utilization of positron emission tomography in the management of patients with sarcoma. Curr Opin Oncol. 2009;21(4):345–51.CrossRefPubMed
16.
James AW, Shurell E, Singh A, et al. Malignant periphera nerve sheath tumor. Surg Oncol Clin N Am. 2016;25:789–802.CrossRefPubMed
17.
Liapis H, Marley EF, Lin Y, et al. p53 and Ki67 proliferating cell nuclear atnigen in benign and malignant peipheral nerve sheath tumors in children. Pediatr Dev Pathol. 1999;2:377–84.CrossRefPubMed
18.
Lee YJ, Moon HG, Soon-Tae Park ST, et al. Malignant peripheral nerve sheath tumor arising from the colon in a newborn: report of a case and review of the literatures. J Pediatr Surg. 2006;41:E19–22.CrossRefPubMed
19.
Kahn J, Gillespie A, Tsokos M, et al. Radiation therapy in management of sporadic and neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors. Front Oncol. 2014;4:324.CrossRefPubMedPubMedCentral
20.
Marwah S, Gurawalia JP, Sheoran KD, et al. Malignant peripheral nerve sheath tumor of the colon in a patient with von Recklinghausen’s disease: report of a case. Clin J Gastroenterol. 2013;6:429–33.CrossRefPubMed
21.
Metadata
Title
A distal ileum malignant peripheral nerve sheath tumor causing intussusception in a patient in China: a case report
Authors
Lin-Bo Zhu
Peng-Fei Li
Wei-Hua Xiao
Peng-Bin Zhang
Jun-Qiang Li
Ming-Fei Sun
Publication date
01-12-2017
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2017
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/s12957-017-1101-z

Other articles of this Issue 1/2017

World Journal of Surgical Oncology 1/2017 Go to the issue

Case Report

Report of a case combining solitary Peutz-Jeghers polyp, colitis cystica profunda, and high-grade dysplasia of the epithelium of the colon

Case report

Bulbar conjunctival metastasis from mucoepidermoid carcinoma of parotid—a case report and review of literature

Research

Long-term survival of hepatocellular carcinoma after percutaneous radiofrequency ablation guided by ultrasound

Research

Total thyroidectomy may be more reasonable as initial surgery in unilateral multifocal papillary thyroid microcarcinoma: a single-center experience

Case report

Debulking surgery for venous hemangioma arising from the epicardium: report of a case

Case Report

Recurrent primary mediastinal giant cell tumor of soft tissue with radiological findings: a rare case report and literature review