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World Journal of Surgical Oncology

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Open Access 01-12-2017 | Research

Study on expression of CDH4 in lung cancer

Authors: Zhupeng Li, Dan Su, Lisha Ying, Guangmao Yu, Weimin Mao

Published in: World Journal of Surgical Oncology | Issue 1/2017

Abstract

Background

The human CDH4 gene, which encodes the R-cadherin protein, has an important role in cell migration and cell adhesion, sorting, tissue morphogenesis, and tumor genesis. This study analyzed the relationship of CDH4 mRNA expression with lung cancer.

Methods

Real time PCR was applied to detect CDH4 mRNA transcription in 142 paired cases of lung cancer and noncancerous regions.

Results

No correlation was identified between CDH4 mRNA expression and gender, age, lymphnode metastasis, TNM stage, family history, smoking state, drinking state (P > 0.05), but grade and histotype (P < 0.05). The relative CDH4 mRNA value was remarkably decreased in lung cancer tissues compared with noncancerous tissues (P = 0.001).

Conclusions

We found that CDH4 mRNA expression was associated with grade and histotype. What is more, the relative CDH4 mRNA value was decreased in the lung cancer tissues. Our results suggested that CDH4 might be a putative tumor suppressor gene (TSG) in lung cancer.

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Title: Study on expression of CDH4 in lung cancer
Authors: Zhupeng Li
Dan Su
Lisha Ying
Guangmao Yu
Weimin Mao
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2017
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/s12957-016-1083-2

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Study on expression of CDH4 in lung cancer

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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