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World Journal of Surgical Oncology

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Open Access 01-12-2017 | Research

Body mass index (BMI) may be a prognostic factor for gastric cancer with peritoneal dissemination

Authors: Shi Chen, Run-Cong Nie, Li-Ying OuYang, Yuan-Fang Li, Jun Xiang, Zhi-Wei Zhou, YingBo Chen, JunSheng Peng

Published in: World Journal of Surgical Oncology | Issue 1/2017

Abstract

Background

The aim of this study is to investigate whether body mass index (BMI) is a prognostic factor in gastric cancer patients with peritoneal dissemination.

Methods

This is a retrospective study consisting of 518 patients with a histological diagnosis of gastric cancer with peritoneal dissemination seen at the Sixth Affiliated Hospital of Sun Yat-Sen University and Sun Yat-sen University Cancer Center between January 2010 and April 2014. Patients were followed until December 2015. Chi-square test and Kaplan-Meier survival analysis were used to compare the clinicopathological variables and prognosis.

Results

Univariate analyses showed that significant prognostic factors included palliative gastrectomy (p < 0.001), tumor size (p < 0.001), tumor location (p = 0.011), peritoneal seeding grade (p < 0.001), ascites (p = 0.001), serum CEA level (p = 0.002), serum CA19-9 level (p = 0.033), palliative chemotherapy (p < 0.001), and BMI group (p < 0.001). For patients with palliative chemotherapy, univariate analysis revealed that palliative gastrectomy (p < 0.001), tumor size (p = 0.002), tumor location (p = 0.024), peritoneal seeding grade (p = 0.008), serum CEA level (p = 0.041), and BMI group (p < 0.001). Multivariate analysis revealed that BMI was an independent prognostic factor in gastric cancer patients with peritoneal dissemination, especially in patients who received palliative chemotherapy.

Conclusions

BMI is a prognostic factor for patients who have gastric cancer with peritoneal dissemination, especially in those who received palliative chemotherapy.

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65(2):87–108.CrossRefPubMed

Chen S, Li YF, Feng XY, Zhou ZW, Yuan XH, Chen YB. Significance of palliative gastrectomy for late-stage gastric cancer patients. J Surg Oncol. 2012;106(7):862–71.CrossRefPubMed

Zhang XF, Huang CM, Lu HS, Wu XY, Wang C, Guang GX, et al. Surgical treatment and prognosis of gastric cancer in 2,613 patients. World J Gastroenterol. 2004;10(23):3405–8. Pubmed Central PMCID: 4576218.CrossRefPubMedPubMedCentral

Hioki M, Gotohda N, Konishi M, Nakagohri T, Takahashi S, Kinoshita T. Predictive factors improving survival after gastrectomy in gastric cancer patients with peritoneal carcinomatosis. World J Surg. 2010;34(3):555–62.CrossRefPubMed

Bang YJ, Van Cutsem E, Feyereislova A, Chung HC, Shen L, Sawaki A, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet. 2010;376(9742):687–97.CrossRefPubMed

Koizumi W, Narahara H, Hara T, Takagane A, Akiya T, Takagi M, et al. S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial. Lancet Oncol. 2008;9(3):215–21.CrossRefPubMed

Janssen I, Heymsfield SB, Allison DB, Kotler DP, Ross R. Body mass index and waist circumference independently contribute to the prediction of nonabdominal, abdominal subcutaneous, and visceral fat. Am J Clin Nutr. 2002;75(4):683–8.PubMed

MacKay NJ. Scaling of human body mass with height: the body mass index revisited. J Biomech. 2010;43(4):764–6.CrossRefPubMed

Amri R, Bordeianou LG, Sylla P, Berger DL. Obesity, outcomes and quality of care: body mass index increases the risk of wound-related complications in colon cancer surgery. Am J Surg. 2014;207(1):17–23. Pubmed Central PMCID: 3865141.CrossRefPubMed

10.

Balentine CJ, Wilks J, Robinson C, Marshall C, Anaya D, Albo D, et al. Obesity increases wound complications in rectal cancer surgery. J Surg Res. 2010;163(1):35–9.CrossRefPubMed

11.

Santoso JT, Barton G, Riedley-Malone S, Wan JY. Obesity and perioperative outcomes in endometrial cancer surgery. Arch Gynecol Obstet. 2012;285(4):1139–44.CrossRefPubMed

12.

Tsai S, Choti MA, Assumpcao L, Cameron JL, Gleisner AL, Herman JM, et al. Impact of obesity on perioperative outcomes and survival following pancreaticoduodenectomy for pancreatic cancer: a large single-institution study. J Gastrointest Surg. 2010;14(7):1143–50.CrossRefPubMed

13.

Bhayani NH, Hyder O, Frederick W, Schulick RD, Wolgang CL, Hirose K, et al. Effect of metabolic syndrome on perioperative outcomes after liver surgery: a National Surgical Quality Improvement Program (NSQIP) analysis. Surgery. 2012;152(2):218–26. Pubmed Central PMCID: 3648869.CrossRefPubMedPubMedCentral

14.

Kodera Y, Ito S, Yamamura Y, Mochizuki Y, Fujiwara M, Hibi K, et al. Obesity and outcome of distal gastrectomy with D2 lymphadenectomy for carcinoma. Hepato-Gastroenterology. 2004;51(58):1225–8.PubMed

15.

Bickenbach KA, Denton B, Gonen M, Brennan MF, Coit DG, Strong VE. Impact of obesity on perioperative complications and long-term survival of patients with gastric cancer. Ann Surg Oncol. 2013;20(3):780–7.CrossRefPubMed

16.

Yasunaga H, Horiguchi H, Matsuda S, Fushimi K, Hashimoto H, Ayanian JZ. Body mass index and outcomes following gastrointestinal cancer surgery in Japan. Br J Surg. 2013;100(10):1335–43.CrossRefPubMed

17.

Kulig J, Sierzega M, Kolodziejczyk P, Dadan J, Drews M, Fraczek M, et al. Implications of overweight in gastric cancer: a multicenter study in a Western patient population. Eur J Surg Oncol. 2010;36(10):969–76.CrossRefPubMed

18.

Ejaz A, Spolverato G, Kim Y, Poultsides GA, Fields RC, Bloomston M, et al. Impact of body mass index on perioperative outcomes and survival after resection for gastric cancer. J Surg Res. 2015;195(1):74–82.CrossRefPubMed

19.

Chen HN, Chen XZ, Zhang WH, Yang K, Chen XL, Zhang B, et al. The impact of body mass index on the surgical outcomes of patients with gastric cancer: a 10-year, single-institution cohort study. Medicine. 2015;94(42):e1769. Pubmed Central PMCID: 4620840.CrossRefPubMedPubMedCentral

20.

Nishi MOY, Miwa K. Japanese classification of gastric carcinoma, Japanese Research Society for Gastric Cancer (JRSGC). 1 Englishth ed. Tokyo: Kanehara & Co; 1995.

21.

Yanovski SZ, Yanovski JA. Obesity prevalence in the United States—up, down, or sideways? N Engl J Med. 2011;364(11):987–9. Pubmed Central PMCID: 3345135.CrossRefPubMedPubMedCentral

22.

Mullen JT, Davenport DL, Hutter MM, Hosokawa PW, Henderson WG, Khuri SF, et al. Impact of body mass index on perioperative outcomes in patients undergoing major intra-abdominal cancer surgery. Ann Surg Oncol. 2008;15(8):2164–72.CrossRefPubMed

23.

Lasithiotakis K, Antoniou SA, Antoniou GA, Kaklamanos I, Zoras O. Gastrectomy for stage IV gastric cancer. A systematic review and meta-analysis. Anticancer Res. 2014;34(5):2079–85.PubMed

24.

Yang K, Liu K, Zhang WH, Lu ZH, Chen XZ, Chen XL, et al. The value of palliative gastrectomy for gastric cancer patients with intraoperatively proven peritoneal seeding. Medicine. 2015;94(27):e1051. Pubmed Central PMCID: 4504616.CrossRefPubMedPubMedCentral

25.

Kokkola A, Louhimo J, Puolakkainen P. Does non-curative gastrectomy improve survival in patients with metastatic gastric cancer? J Surg Oncol. 2012;106(2):193–6.CrossRefPubMed

Title: Body mass index (BMI) may be a prognostic factor for gastric cancer with peritoneal dissemination
Authors: Shi Chen
Run-Cong Nie
Li-Ying OuYang
Yuan-Fang Li
Jun Xiang
Zhi-Wei Zhou
YingBo Chen
JunSheng Peng
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2017
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/s12957-016-1076-1

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Body mass index (BMI) may be a prognostic factor for gastric cancer with peritoneal dissemination

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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