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World Journal of Surgical Oncology
Published in: World Journal of Surgical Oncology 1/2017

Open Access 01-12-2017 | Research

Pasteurized autograft reconstruction after resection of periacetabular malignant bone tumours

Authors: Xiaoning Guo, Xiaoyang Li, Tang Liu, Cijun Shuai, Qing Zhang

Published in: World Journal of Surgical Oncology | Issue 1/2017

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Abstract

Background

The treatment of periacetabular malignant bone tumours is challenging. Many methods of reconstruction after internal hemipelvectomy have been reported and each method has its own limitations. The aim of this study was to evaluate the oncological and functional outcomes of pasteurized autograft reconstruction after resection of periacetabular malignant bone tumours.

Methods

Ten patients (six male, four female) with periacetabular malignant tumours, who underwent resection and reconstruction with pasteurized autograft, were retrospectively reviewed. The patients’ average age at diagnosis was 40 years (range 13–65 years). There were five patients with chondrosarcoma, three with osteosarcoma, one with Ewing’s sarcoma, and one with solitary metastatic thyroid carcinoma.

Results

At the last follow-up, seven patients were alive (six with no evidence of the primary disease and one with lung metastasis for 5 months). The three other patients died of metastasis of the primary disease with a mean survival time of 12 (range 8–17) months postoperatively. The mean follow-up time for all patients was 45 (range 8–87) months. Local recurrence rate was 10%. The mean time of bone union was 12 (range 6–21) months after the operation. The mean Musculoskeletal Tumor Society score for all living patients at the last follow-up was 70.5% (range 43.3–86.7%).

Conclusions

Reconstruction with pasteurized autograft is a feasible method for treating periacetabular malignant bone tumours, with satisfactory oncological and functional outcomes and a relatively low incidence of complications.
Literature
1.
Wirbel RJ, Schulte M, Mutschler WE. Surgical treatment of pelvic sarcomas: oncologic and functional outcome. Clin Orthop Relat Res. 2001;390:190–205.CrossRef
2.
Ueda T, Kakunaga S, Takenaka S, et al. Constrained total hip megaprosthesis for primary periacetabular tumors. Clin Orthop Relat Res. 2013;471(3):741–9.CrossRefPubMed
3.
Enneking WF, Dunham WK. Resection and reconstruction for primary neoplasms involving the innominate bone. J Bone Joint Surg Am. 1978;60(6):731–46.CrossRefPubMed
4.
Yu G, Zhang F, Zhou J, et al. Microsurgical fibular flap for pelvic ring reconstruction after periacetabular tumor resection. J Reconstr Microsurg. 2007;23(3):137–42.CrossRefPubMed
5.
Hu YC, Huang HC, Lun DX, et al. Resection hip arthroplasty as a feasible surgical procedure for periacetabular tumors of the pelvis. Eur J Surg Oncol. 2012;38(8):692–9.CrossRefPubMed
6.
Hillmann A, Hoffmann C, Gosheger G, et al. Tumors of the pelvis: complications after reconstruction. Arch Orthop Trauma Surg. 2003;123(7):340–4.CrossRefPubMed
7.
Johnson JT. Reconstruction of the pelvic ring following tumor resection. J Bone Joint Surg Am. 1978;60(6):747–51.CrossRefPubMed
8.
Satcher Jr RL, O’donnell RJ, Johnston JO. Reconstruction of the pelvis after resection of tumors about the acetabulum. Clin Orthop Relat Res. 2003;409:209–17.CrossRef
9.
Ozaki T, Hoffmann C, Hillmann A, et al. Implantation of hemipelvic prosthesis after resection of sarcoma. Clin Orthop Relat Res. 2002;396:197–205.CrossRef
10.
Dai KR, Yan MN, Zhu ZA, et al. Computer-aided custom-made hemipelvic prosthesis used in extensive pelvic lesions. J Arthroplasty. 2007;22(7):981–6.CrossRefPubMed
11.
Wong KC, Kumta SM, Chiu KH, et al. Computer assisted pelvic tumor resection and reconstruction with a custom-made prosthesis using an innovative adaptation and its validation. Comput Aided Surg. 2007;12(4):225–32.CrossRefPubMed
12.
Witte D, Bernd L, Bruns J, et al. Limb-salvage reconstruction with MUTARS hemipelvic endoprosthesis: a prospective multicenter study. Eur J Surg Oncol. 2009;35(12):1318–25.CrossRefPubMed
13.
Guo Z, Li J, Pei GX, et al. Pelvic reconstruction with a combined hemipelvic prostheses after resection of primary malignant tumor. Surg Oncol. 2010;19(2):95–105.CrossRefPubMed
14.
Sun W, Li J, Li Q, et al. Clinical effectiveness of hemipelvic reconstruction using computer-aided custom-made prostheses after resection of malignant pelvic tumors. J Arthroplasty. 2011;26(8):1508–13.CrossRefPubMed
15.
Tang X, Guo W, Ji T. Reconstruction with modular hemipelvic prosthesis for the resection of solitary periacetabular metastasis. Arch Orthop Trauma Surg. 2011;131(12):1609–15.CrossRefPubMed
16.
Zhou Y, Duan H, Liu Y, et al. Outcome after pelvic sarcoma resection and reconstruction with a modular hemipelvic prostheses. Int Orthop. 2011;35(12):1839–46.CrossRefPubMedPubMedCentral
17.
Ji T, Guo W, Yang RL, et al. Modular hemipelvic endoprosthesis reconstruction—experience in 100 patients with mid-term follow-up results. Eur J Surg Oncol. 2013;39(1):53–60.CrossRefPubMed
18.
Harrington KD. The use of hemipelvic allografts or autoclaved grafts for reconstruction after wide resections of malignant tumors of the pelvis. J Bone Joint Surg Am. 1992;74(3):331–41.CrossRefPubMed
19.
Langlais F, Lambotte JC, Thomazeau H. Long-term results of hemipelvis reconstruction with allografts. Clin Orthop Relat Res. 2001;388:178–86.CrossRef
20.
Delloye C, Banse X, Brichard B, et al. Pelvic reconstruction with a structural pelvic allograft after resection of a malignant bone tumor. J Bone Joint Surg Am. 2007;89(3):579–87.PubMed
21.
Krieg AH, Mani M, Speth BM, et al. Extracorporeal irradiation for pelvic reconstruction in Ewing’s sarcoma. J Bone Joint Surg (Br). 2009;91(3):395–400.CrossRef
22.
Wafa H, Grimer RJ, Jeys L, et al. The use of extracorporeally irradiated autografts in pelvic reconstruction following tumour resection. Bone Joint J. 2014;96-B(10):1404–10.CrossRefPubMed
23.
Jeon DG, Kim MS, Cho WH, et al. Reconstruction with pasteurized autograft-total hip prosthesis composite for periacetabular tumors. J Surg Oncol. 2007;96(6):493–502.CrossRefPubMed
24.
Kim HS, Kim KJ, Han I, et al. The use of pasteurized autologous grafts for periacetabular reconstruction. Clin Orthop Relat Res. 2007;464:217–23.PubMed
25.
Liu T, Guo X, Zhang X, et al. Reconstruction with pasteurized autograft for primary malignant bone tumor of distal tibia. Bull Cancer. 2012;99(9):87–91.PubMed
26.
Liu T, Zhang Q, Guo X, et al. Treatment and outcome of malignant bone tumors of the proximal humerus: biological versus endoprosthetic reconstruction. BMC Musculoskelet Disord. 2014;15:69.CrossRefPubMedPubMedCentral
27.
Enneking WF, Dunham W, Gebhardt MC, et al. A system for the functional evaluation of reconstructive procedures after surgical treatment of tumors of the musculoskeletal system. Clin Orthop Relat Res. 1993;286:241–6.
28.
Uchida A, Myoui A, Araki N, et al. Prosthetic reconstruction for periacetabular malignant tumors. Clin Orthop Relat Res. 1996;326:238–45.CrossRef
29.
Sugiura H, Nishida Y, Nakashima H, et al. Evaluation of long-term outcomes of pasteurized autografts in limb salvage surgeries for bone and soft tissue sarcomas. Arch Orthop Trauma Surg. 2012;132(12):1685–95.CrossRefPubMed
30.
Jeon DG, Kim MS, Cho WH, et al. Pasteurized autograft for intercalary reconstruction: an alternative to allograft. Clin Orthop Relat Res. 2007;456:203–10.CrossRefPubMed
31.
Suk KS, Shin KH, Hahn SB. Limb salvage using original low heat-treated tumor-bearing bone. Clin Orthop Relat Res. 2002;397:385–93.CrossRef
32.
Manabe J, Kawaguchi N, Matsumoto S. Pasteurized autogenous bone graft for reconstruction after resection of malignant bone and soft tissue tumors: imaging features. Semin Musculoskelet Radiol. 2001;5(2):195–201.CrossRefPubMed
33.
Holzapfel BM, Pilge H, Prodinger PM, et al. Customised osteotomy guides and endoprosthetic reconstruction for periacetabular tumours. Int Orthop. 2014;38(7):1435–42.PubMedPubMedCentral
34.
Manabe J, Ahmed AR, Kawaguchi N, et al. Pasteurized autologous bone graft in surgery for bone and soft tissue sarcoma. Clin Orthop Relat Res. 2004;419:258–66.CrossRef
35.
Sakayama K, Kidani T, Fujibuchi T, et al. Reconstruction surgery for patients with musculoskeletal tumor, using a pasteurized autogenous bone graft. Int J Clin Oncol. 2004;9(3):167–73.CrossRefPubMed
36.
37.
Mankin HJ, Hornicek FJ, Temple HT, et al. Malignant tumors of the pelvis: an outcome study. Clin Orthop Relat Res. 2004;425:212–7.CrossRef
38.
Hoffmann C, Gosheger G, Gebert C, et al. Functional results and quality of life after treatment of pelvic sarcomas involving the acetabulum. J Bone Joint Surg Am. 2006;88(3):575–82.PubMed
39.
Fujiwara T, Ogura K, Kobayashi E, et al. Clinical outcomes of surgical treatments for primary malignant bone tumors arising in the acetabulum. Sarcoma. 2015;2015:430576.CrossRefPubMedPubMedCentral
40.
Fisher NE, Patton JT, Grimer RJ, et al. Ice-cream cone reconstruction of the pelvis: a new type of pelvic replacement: early results. J Bone Joint Surg (Br). 2011;93(5):684–8.CrossRef
Metadata
Title
Pasteurized autograft reconstruction after resection of periacetabular malignant bone tumours
Authors
Xiaoning Guo
Xiaoyang Li
Tang Liu
Cijun Shuai
Qing Zhang
Publication date
01-12-2017
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2017
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/s12957-016-1065-4

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