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World Journal of Surgical Oncology

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Open Access 01-12-2016 | Research

TNRC9 rs12443621 and FGFR2 rs2981582 polymorphisms and breast cancer risk

Authors: Ying Chen, Chunying Shi, Qiyong Guo

Published in: World Journal of Surgical Oncology | Issue 1/2016

Abstract

Background

This study is to investigate the association of fibroblast growth factor receptor 2 (FGFR2) rs2981582, trinucleotide-repeat-containing 9 (TNRC9) rs3803662, rs12443621, and leukocyte-specific protein 1 (LSP1) rs3817198 polymorphisms with breast cancer and mammographic density in Han Chinese population.

Methods

TaqMan Single Nucleotide Polymorphism (SNP) Genotyping Assays and unconditional logistic regression analysis were used to examine these SNPs in 105 breast cancer cases and 382 controls.

Results

The genotype frequencies of rs12443621 and rs2981582 were significantly different between controls and cases (P = 0.017 and 0.006, respectively). Subjects carrying G allele of rs12443621 had increased breast cancer risk (AG vs AA: OR = 2.017, 95 % CI = 0.910–4.471; GG vs AA: OR = 2.684, 95 % CI = 1.318–5.463). Subjects carrying an allele of rs2981582 had reduced breast cancer risk (GA vs GG: OR = 0.444, 95 % CI = 0.262–0.752; AA vs GG: OR = 0.579, 95 % CI = 0.342–0.983). rs3803662 and rs3817198 SNPs did not significantly differ between cases and controls (P = 0.408 and 0.116, respectively). Interestingly, the AA genotype of rs2981582 was also associated with reduced mammographic densities (P = 0.0092, 95 % CI = 0.334–0.926).

Conclusions

Our findings indicate that the GG genotype of rs12443621 is associated with increased breast cancer risk whereas the GA and AA genotypes of rs2981582 are reduced risk in Han Chinese population.

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Title: TNRC9 rs12443621 and FGFR2 rs2981582 polymorphisms and breast cancer risk
Authors: Ying Chen
Chunying Shi
Qiyong Guo
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2016
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/s12957-016-0795-7

At a glance: The STEP trials

Springer Medicine

TNRC9 rs12443621 and FGFR2 rs2981582 polymorphisms and breast cancer risk

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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