Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
World Journal of Surgical Oncology
Published in: World Journal of Surgical Oncology 1/2015

Open Access 01-12-2015 | Research

Thoracic perfusion of matrine as an adjuvant treatment improves the control of the malignant pleural effusions

Authors: Rong Biaoxue, Ma Shuxia, Gao Wenlong, Yang Shuanying

Published in: World Journal of Surgical Oncology | Issue 1/2015

Login to get access

Abstract

Background

Many studies have investigated the efficacy and safety of matrine in treating malignant pleural effusion by thoracic perfusion. This study is an analytic value of available evidence.

Methods

Twelve studies were analyzed in this study. Pooled odds ratios and hazard ratio with 95 % confidence intervals were calculated using the fixed effects model.

Results

Overall response rate of matrine combined with other medications in treating malignant pleural effusion (MPE) was significantly higher than those of other medications alone (p < 0.05). Time to pleural effusion relief and quality of life were improved after the treatment of matrine combined with other medications (p < 0.05). Moreover, matrine combined with other medications had a lower incidence of adverse reactions (p < 0.05).

Conclusions

Matrine combined with other medications improves the control of the malignant pleural effusions and decreases the incidence of adverse reactions.
Literature
1.
Stathopoulos GT, Kalomenidis I. Malignant pleural effusion tumor-host interactions unleashed. Am J Respir Crit Care Med. 2012;186:487–92.CrossRefPubMed
2.
Ma L, Wen S, Zhan Y, He Y, Liu X, Jiang J. Anticancer effects of the Chinese medicine matrine on murine hepatocellular carcinoma cells. Planta Med. 2008;74:245–51.CrossRefPubMed
3.
Liu XY, Fang H, Yang ZG, Wang XY, Ruan LM, Fang DR, et al. Matrine inhibits invasiveness and metastasis of human malignant melanoma cell line A375 in vitro. Int J Dermatol. 2008;47:448–56.CrossRefPubMed
4.
Luo C, Zhu Y, Jiang T, Lu X, Zhang W, Jing Q, et al. Matrine induced gastric cancer MKN45 cells apoptosis via increasing pro-apoptotic molecules of Bcl-2 family. Toxicology. 2007;229:245–52.CrossRefPubMed
5.
Zhang L, Wang T, Wen X, Wei Y, Peng X, Li H, et al. Effect of matrine on HeLa cell adhesion and migration. Eur J Pharmacol. 2007;563:69–76.CrossRefPubMed
6.
Cao H, Liu J, Lewith GT. Traditional Chinese medicine for treatment of fibromyalgia: a systematic review of randomized controlled trials. J Altern Complement Med. 2010;16:397–409.PubMedCentralCrossRefPubMed
7.
Cirocchi R, D'Ajello F, Trastulli S, Santoro A, Di Rocco G, Vendettuoli D, et al. Meta-analysis of thyroidectomy with ultrasonic dissector versus conventional clamp and tie. World J Surg Oncol. 2010;8:112.PubMedCentralCrossRefPubMed
8.
Li C. Effect of compound matrine injection on malignant pleural effusion. Chinese Journal of New Drugs. 2013;22:2069–74.
9.
Zenmin L, Huixian L, Zhanjie L, Ruiling L, Yanshuang Z. Efficacy of compound matrine injection for malignant pleural effusion. Evaluation and analysis of drug-use in hospitals of China. 2011;11:547–8.
10.
Xiaowei Z, Shuming G, Yunliang W. Clinical observation of compound kushen injection combined with mitomycin for malignant pleural effusion. Chin J Clin Oncol Rehabil. 2013;20:780–2.
11.
Liangfa Z, Zuowei H, Tao X. Clinical observation of compound kushen injection combined with cisplatin for malignant pleural effusion. Journal of Guiyang College of Traditional Chinese Medicine. 2012;34:145–7.
12.
Zhiwen H, Hongyan Z, Kai Z, Leishan G. The clinical research of compound kushen injection and corynebacterium parvum as a local therapy for patients with advanced lung cancer associated with malignant pleural effusion. Journal of Clinical Pulmonary Medicine. 2012;17:497–8.
13.
Sijie L, Hong L, Jianwei B. Short-term efficacy observation of compound kuh-seng injection plus interleukin II and cisplatin for malignant pleural effusion. Modern Medicine Journal of China. 2011;13:42–4.
14.
Ziqiang G. Efficacy of matrine injections and interleukin-2 treatment of malignant pleural effusion. Henan Medical Research. 2013;22:499–501.
15.
Yunfang C, Qi L, Sen X, Guanghua Y. Compound kusheng injection combined with cisplatin for malignant pleural effusion: a clinical study. Evaluation and analysis of drug-use in hospitals of China. 2011;11:366–7.
16.
Yushun J, Jie Y. Clinical research on weekly-dose of cisplatin intrapleural infusion combined with compound kushen injection in treatment of non-small cell lung cancer complicating malignant pleural effusion. J Mod Med Health. 2013;29:1619–20.
17.
Zhenfeng W, Ran Z, Qinyi L, Guangjie L. Therapeutic effect of hydroxycamptothecin combined with kushen injection on malignant pleural effusion in elderly patients with lung cancer. Hebei Medical Journal. 2014;36:3705–7.
18.
Guoan X. Clinical observation of compound kushen injection combined with bleomycin for malignant pleural effusion. Anhui Medical and Pharmaceutical Journal. 2013;17:131–2.
19.
Daiju H, Xiaodong M. Observing therapeutic efficiency of fufangkushen injection, IL-2, α-IFN on lung cancer accompanied with malignancy pleural effusions. Journal of Clinical Pulmonary Medicine. 2012;17:1844–5.
20.
Liu Y, Xu Y, Ji W, Li X, Sun B, Gao Q, et al. Anti-tumor activities of matrine and oxymatrine: literature review. Tumour Biol. 2014;35:5111–9.CrossRefPubMed
21.
Tan C, Qian X, Jia R, Wu M, Liang Z. Matrine induction of reactive oxygen species activates p38 leading to caspase-dependent cell apoptosis in non-small cell lung cancer cells. Oncol Rep. 2013;30:2529–35.PubMed
Metadata
Title
Thoracic perfusion of matrine as an adjuvant treatment improves the control of the malignant pleural effusions
Authors
Rong Biaoxue
Ma Shuxia
Gao Wenlong
Yang Shuanying
Publication date
01-12-2015
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2015
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/s12957-015-0729-9

Other articles of this Issue 1/2015

World Journal of Surgical Oncology 1/2015 Go to the issue

Case report

Surgical resection of solid gallbladder adenocarcinoma presenting as a large mass: report of a case

Research

Surgical resections of ulcerative colitis associated with dysplasia or carcinoma

Case report

Appendiceal mixed adenoneuroendocrine carcinomas, a rare entity that can present as a Krukenberg tumor: case report and review of the literature

Research

Elevated matrix metalloproteinase-7 expression promotes metastasis in human lung carcinoma

Research

Prognostic role of hormone receptors in endometrial cancer: a systematic review and meta-analysis

Research

Systematic review and meta-analysis of totally laparoscopic versus laparoscopic assisted distal gastrectomy for gastric cancer