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Open Access 01-12-2015 | Research

CXCR2 expression and postoperative complications affect long-term survival in patients with esophageal cancer

Authors: Tomohiko Nishi, Hiroya Takeuchi, Sachiko Matsuda, Masaharu Ogura, Hirofumi Kawakubo, Kazumasa Fukuda, Rieko Nakamura, Tsunehiro Takahashi, Norihito Wada, Yoshiro Saikawa, Tai Omori, Yuko Kitagawa

Published in: World Journal of Surgical Oncology | Issue 1/2015

Abstract

Background

Esophagectomy is one of the most invasive surgical treatments for digestive tract cancer, and the blood levels of inflammatory cytokines such as interleukin-1, interleukin-6, and interleukin-8 are increased for several hours after surgery or in patients experiencing postoperative complications. CXCR2, an interleukin-8 receptor, is reportedly expressed in several carcinomas, and interleukin-8 signaling promotes cancer cell proliferation. The impact of postoperative complications following esophagectomy on long-term survival is controversial. In this study, we demonstrate the significance of CXCR2 expression and validate the effects of CXCR2 expression and postoperative complications on long-term prognosis of esophageal squamous cell carcinoma using resected specimens.

Methods

Eighty-two specimens were sectioned from archived, paraffin-embedded tumor tissues obtained from patients with esophageal squamous cell carcinoma who underwent esophagectomy and extended lymphadenectomy for complete resection of cancer in our institute between 1997 and 2002. Immunohistochemistry was performed using a polyclonal antibody to CXCR2, and the correlation of stainability with clinicopathological factors and long-term survival was examined.

Results

CXCR2 was expressed in 33 of 82 (40.2 %) specimens. In the CXCR2-positive group, the recurrence-free survival and overall survival rates of patients who developed postoperative complications were both significantly lower than those for patients who did not develop any complications. In contrast, in the CXCR2-negative group, there was no significant difference in long-term prognosis between patients with and without complications. CXCR2 positivity combined with postoperative complications was an independent risk factor for subsequent tumor recurrence, showing the highest hazard ratio.

Conclusions

Our results suggest that the patients with CXCR2-positive esophageal cancer who develop postoperative complications have a poor prognosis and should be carefully followed.

Trial registration

This study was approved by Keio University School of Medicine Ethics Committee with a trial registration number of 2011-241.

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Title: CXCR2 expression and postoperative complications affect long-term survival in patients with esophageal cancer
Authors: Tomohiko Nishi
Hiroya Takeuchi
Sachiko Matsuda
Masaharu Ogura
Hirofumi Kawakubo
Kazumasa Fukuda
Rieko Nakamura
Tsunehiro Takahashi
Norihito Wada
Yoshiro Saikawa
Tai Omori
Yuko Kitagawa
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2015
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/s12957-015-0658-7

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

CXCR2 expression and postoperative complications affect long-term survival in patients with esophageal cancer

Abstract

Background

Methods

Results

Conclusions

Trial registration

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Trial registration

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