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World Journal of Surgical Oncology

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Open Access 01-12-2015 | Research

Clinicopathological significance of KAI1 expression and epithelial-mesenchymal transition in non-small cell lung cancer

Authors: Lei Zhou, Lan Yu, Shiwu Wu, Zhenzhong Feng, Wenqing Song, Xiaomeng Gong

Published in: World Journal of Surgical Oncology | Issue 1/2015

Abstract

Background

KAI1 and epithelial-mesenchymal transition (EMT) is related to both angiogenesis and lymphangiogenesis and is an important target in new cancer treatment strategies. We aimed to investigate the KAI1 and marker of EMT expression and correlation with lymph node metastasis (LNM) and explore their prognostic impact in non-small cell lung cancer (NSCLC).

Methods

Tumor tissue specimens from 312 resected patients with stage I–IIIA NSCLC were obtained. Immunohistochemistry was used to assess the expression of the molecular markers KAI1, E-cadherin (E-cad), vimentin, CD34, and D2-40.

Results

There were 153 N0 and 159 N+ patients. Tumor cell expression of KAI1and the marker of EMT, lymphatic vessel density (LVD), and microvessel density (MVD) were related to LNM. In multivariate analyses, the ages of patients, high tumor cell KAI1 expression, EMT, and the scores of MVD were independent factor of prognosis.

Conclusions

Tumor cell KAI1 expression, EMT, LVD, and MVD correlate with LNM. Thus, the detection of KAI1, expression of markers of EMT, and the scores of MVD may be used as a potential indicator of NSCLC prognosis.

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Title: Clinicopathological significance of KAI1 expression and epithelial-mesenchymal transition in non-small cell lung cancer
Authors: Lei Zhou
Lan Yu
Shiwu Wu
Zhenzhong Feng
Wenqing Song
Xiaomeng Gong
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2015
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/s12957-015-0657-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Clinicopathological significance of KAI1 expression and epithelial-mesenchymal transition in non-small cell lung cancer

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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