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World Journal of Surgical Oncology

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Open Access 01-12-2015 | Research

Prognostic and clinical significance of claudin-4 in gastric cancer: a meta-analysis

Authors: Jin-xin Liu, Zhao-yi Wei, Jian-she Chen, Hai-chao Lu, Liang Hao, Wen-jing Li

Published in: World Journal of Surgical Oncology | Issue 1/2015

Abstract

Background

The current reports on the association of claudin-4 expression with gastric cancer outcome were inconsistent. Thus, we conducted a meta-analysis to assess the association of claudin-4 expression with the prognosis and clinical parameters more precisely.

Methods

Systematic searches on PubMed, Embase, and Cochrane Library prior to December 2014 were performed. The pooled hazard ratio (HR) with its 95 % confidence interval (95 %CI) was used to assess the prognostic value of claudin-4 expression with gastric cancer patients, and the pooled odds ratio (OR) with its 95 %CI was used to assess the association with clinical parameters.

Results

Nine studies with a total of 1265 gastric cancer patients were included. Overall, the pooled results showed that over-expression of claudin-4 was associated with a poor survival in gastric cancer patients (HR: 2.01, 95 % CI: 1.62–2.50). Over-expression of claudin-4 was also associated with advanced stage (OR: 1.96, 95 % CI: 1.08–3.56) and lymphoid node metastasis (OR: 1.72, 95 % CI: 1.05–2.81) of gastric cancer patients. No significant publication bias was found among the studies (P > 0.05).

Conclusions

This meta-analysis shows that over-expression of claudin-4 is associated with progress of gastric cancer and poor prognosis of gastric cancer patients.

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Title: Prognostic and clinical significance of claudin-4 in gastric cancer: a meta-analysis
Authors: Jin-xin Liu
Zhao-yi Wei
Jian-she Chen
Hai-chao Lu
Liang Hao
Wen-jing Li
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2015
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/s12957-015-0626-2

At a glance: The STEP trials

Springer Medicine

Prognostic and clinical significance of claudin-4 in gastric cancer: a meta-analysis

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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