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World Journal of Surgical Oncology
Published in: World Journal of Surgical Oncology 1/2015

Open Access 01-12-2015 | Research

Follicular thyroid carcinoma: differences in clinical relevance between minimally invasive and widely invasive tumors

Authors: Mauro Podda, Alessandra Saba, Federica Porru, Isabella Reccia, Adolfo Pisanu

Published in: World Journal of Surgical Oncology | Issue 1/2015

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Abstract

Background

Evidence on the biological behavior and clinical courses of minimally invasive and widely invasive follicular thyroid carcinoma (MI-FTC, WI-FTC) is still debatable. The current study was conducted to identify differences between MI and WI tumors and those prognostic parameters influencing late outcome such as local recurrence and survival.

Methods

From January 1998 to October 2013, 71 patients were operated on in our department because of a FTC. A retrospective cohort study was carried out to compare 42 MI-FTC and 29 WI-FTC. The comparison involved evaluation of patient characteristics, tumor characteristics, tumor staging, and risk assessment.

Results

A diameter greater than 4.0 cm, the presence of vascular invasion, the TNM stage III–IVA, and the high risk at AMES system risk stratification were independent factors significantly related to the presence of a WI-FTC. The only independent predictor of recurrence and disease-free survival at 10-year follow-up was a tumor size greater than 4.0 cm.

Conclusions

More attention must be paid in the postoperative tumor re-staging of those patients with tumor size larger than 4.0 cm, which was the only parameter predicting recurrence and influencing disease-free survival. Nevertheless, definitive recommendations cannot be made without a longer follow-up.
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Metadata
Title
Follicular thyroid carcinoma: differences in clinical relevance between minimally invasive and widely invasive tumors
Authors
Mauro Podda
Alessandra Saba
Federica Porru
Isabella Reccia
Adolfo Pisanu
Publication date
01-12-2015
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2015
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/s12957-015-0612-8

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