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World Journal of Surgical Oncology
Published in: World Journal of Surgical Oncology 1/2015

Open Access 01-12-2015 | Research

The prognostic significance of a postoperative systemic inflammatory response in patients with colorectal cancer

Authors: Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Hiroshi Ohtani, Yasuhito Iseki, Tetsuro Ikeya, Kenji Sugano, Kosei Hirakawa

Published in: World Journal of Surgical Oncology | Issue 1/2015

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Abstract

Background

Recently, a preoperative systemic inflammatory response has been reported to be a prognostic factor in patients with colorectal cancer (CRC). However, the prognostic significance of a systemic inflammatory response in the early stage after surgery in patients with CRC is unknown. The aim of this retrospective study was to evaluate the prognostic significance of a postoperative systemic inflammatory response in patients with CRC.

Methods

Two hundred and fifty-four patients who underwent potentially curative surgery for stage II/III CRC were enrolled in this study. Univariate and multivariate analyses were performed to evaluate the relationship between the prognosis and clinicopathological factors, including the neutrophil-to-lymphocyte ratio (NLR) and Glasgow Prognostic Score (GPS), which were measured within two weeks before operation and at the first visit after leaving the hospital.

Results

The overall survival rates were significantly worse in the high preoperative NLR/preoperative GPS/postoperative NLR group. A multivariate analysis indicated that only preoperative GPS, postoperative NLR, and the number of lymph node metastases were independent prognostic factors for a poor survival.

Conclusions

The postoperative NLR is an independent prognostic factor in patients with CRC who underwent potentially curative surgery.
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Metadata
Title
The prognostic significance of a postoperative systemic inflammatory response in patients with colorectal cancer
Authors
Masatsune Shibutani
Kiyoshi Maeda
Hisashi Nagahara
Hiroshi Ohtani
Yasuhito Iseki
Tetsuro Ikeya
Kenji Sugano
Kosei Hirakawa
Publication date
01-12-2015
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2015
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/s12957-015-0609-3

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