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Health and Quality of Life Outcomes
Published in: Health and Quality of Life Outcomes 1/2020

01-12-2020 | Scleroderma | Short report

Health-related quality of life and its influencing factors in adult patients with localized scleroderma - a cross-sectional study

Authors: Anna Lis-Święty, Alina Skrzypek-Salamon, Irmina Ranosz-Janicka, Ligia Brzezińska-Wcisło

Published in: Health and Quality of Life Outcomes | Issue 1/2020

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Abstract

Background

Localized Scleroderma (LoS) is an autoimmune connective tissue disease that affects skin and less commonly subcutaneous tissues. The illness occurs in children and adults, and may have a serious impact on health-related quality of life (HRQoL). The goal of this study was to explore what factors might deteriorate scores on HRQoL measures in adult LoS patients.

Methods

Detailed information on the demographic and clinical features of LoS patients was collected. The HRQoL was assessed using Skindex-29 and Short form 36 (SF-36) questionnaires.

Results

Thirty three women and seven men with LoS were enrolled. Female gender negatively influenced scores for the emotion subscale of Skindex-29. Multiple-factor linear regression analysis confirmed, as with single-factor analysis, that the causes of low SF-36 physical component score (PCS) were subjective symptoms (pruritus, pain, paresthesia), musculoskeletal manifestations and older age at the time of survey, while rural area of residence negatively affected the SF-36 mental component score. Additionally, single-factor analysis showed that the SF-36 PCS was related to the LoS cutaneous assessment tool (LoSCAT) summary score.

Conclusions

Apart from a clinical presentations, sociodemographic characteristics, including older age, female gender and living conditions, may impair HRQoL of LoS patients. Further studies that will examine the role of these factors for physical and mental functioning of adults with LoS are needed.
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Metadata
Title
Health-related quality of life and its influencing factors in adult patients with localized scleroderma - a cross-sectional study
Authors
Anna Lis-Święty
Alina Skrzypek-Salamon
Irmina Ranosz-Janicka
Ligia Brzezińska-Wcisło
Publication date
01-12-2020
Publisher
BioMed Central
Keyword
Scleroderma
Published in
Health and Quality of Life Outcomes / Issue 1/2020
Electronic ISSN: 1477-7525
DOI
https://doi.org/10.1186/s12955-020-01386-0

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