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Health and Quality of Life Outcomes

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Open Access 01-12-2018 | Research

Localized Scleroderma Cutaneous Assessment Tool (LoSCAT) adapted for use in adult patients: report from an initial validation study

Authors: Alina Skrzypek-Salamon, Anna Lis-Święty, Irmina Ranosz-Janicka, Ligia Brzezińska-Wcisło

Published in: Health and Quality of Life Outcomes | Issue 1/2018

Abstract

Background

Localized scleroderma (LoS) affects both children and adults and is associated with permanent functional and cosmetic impairment, and reduced quality of life predominating in adults. The Localized Scleroderma Cutaneous Assessment Tool (LoSCAT) is a clinical instrument designed to measure an activity and damage of LoS. It has been validated for use with pediatric LoS patients. This study assessed the validity and reliability of the LoSCAT adapted for use in adults.

Methods

Before the initiation of the study two examiners participated in an intensive training course carried out by an expert in LoS. Appendices describing each LoSCAT domain were prepared. Features determining disease activity and damage in adult LoS patients were identified to properly evaluate the physician (Phys) and patient (Pt) global assessment (GA) of disease activity (A)/severity (S) and damage (D), which were used to assess convergent validity of the LoSCAT. Correlations of physician- and patient-derivied measures with Skindex-29 were also analysed.

Results

The study included 40 adult LoS patients (33 females and 7 males) with different subtypes of LoS. Intra and inter-rater reliability of the LoSCAT was found to be excellent. Positive correlations were observed between the PhysGA-A, PhysGA-D, PtGA-A and the LoSCAT’s domains, while no correlations between them and the PtGA-D were found. There were no relationships between LoSCAT’s components and Skindex-29.

Conclusions

Despite the LoSCAT is a reliable tool for an assessment of cutaneous lesions, additional health status instruments are necessary to a holistic approach to LoS in adults.

Lis-Święty A, Skrzypek-Salamon A, Ranosz-Janicka I, Brzezińska-Wcisło L. Localized scleroderma: clinical and epidemiological features with emphasis on adulthood- versus childhood-onset disease differences. J Eur Acad Dermatol Venereol. 2017;31:1595–603. https://doi.org/10.1111/jdv.14197.CrossRefPubMed

Kelsey CE, Torok KS. The localized scleroderma cutaneous assessment tool: responsiveness to change in a pediatric clinical population. J Am Dermatology. 2013;69:214–20. https://doi.org/10.1016/j.jaad.2013.02.007.CrossRef

Arkachaisri T, Vilaiyuk S, Li S, O'Neil KM, Pope E, Higgins GC, et al. The localized scleroderma skin severity index and physician global assessment of disease activity: a work in progress toward development of localized scleroderma outcome measures. J Rheumatol. 2013;36:2819–29. https://doi.org/10.3899/jrheum.081284.CrossRef

Arkachaisri T, Vilaiyuk S, Torok KS, Medsger TA Jr. Development and initial validation of the localized scleroderma skin damage index and physician global assessment of disease damage : a proof-of-concept study. Rheumatology (Oxford). 2010;49:373–81. https://doi.org/10.1093/rheumatology/kep361.CrossRef

Cunningham BB, Landells ID, Langman C, Sailer DE, Paller AS. Topical calcipotriene for morphea / linear scleroderma. J Am Acad Dermatol. 1998;39:211–5. https://doi.org/10.1016/S0190-9622(98)70077-5.CrossRefPubMed

Pope E, Doria AS, Theriault M, Mohanta A, Laxer RM. Topical imiquimod 5% cream for pediatric plaque morphea: a prospective, multiple-baseline, open-label pilot study. Dermatology. 2011;223:363–9. https://doi.org/10.1159/000335560.CrossRefPubMed

Zulian F, Meneghesso D, Grisan E, Vittadello F, Belloni Fortina A, Pigozzi B, et al. A new computerized method for the assessment of skin lesions in localized scleroderma. Rheumatology (Oxford). 2007;46:856–60. https://doi.org/10.1093/rheumatology/kel446.CrossRef

Arkachaisri T, Pino S. Localized scleroderma severity index and global assessments: a pilot study of outcome instruments. J Rheumatol. 2008;35:650–7.CrossRefPubMed

Torok KS, Arkachaisri T. Methotrexate and corticosteroids in the treatment of localized scleroderma: a standardized prospective longitudinal single-center study. J Rheumatol. 2012;39:286–94. https://doi.org/10.3899/jrheum.110210.CrossRefPubMedPubMedCentral

10.

Shalaby SM, Bosseila M, Fawzy MM, Abdel Halim DM, Sayed SS, Allam RS. Fractional carbon dioxide laser versus low-dose UVA-1 phototherapy for treatment of localized scleroderma: a clinical and immunohistochemical randomized controlled study. Lasers Med Sci. 2016;31:1707–15. https://doi.org/10.1007/s10103-016-2041-5.CrossRefPubMed

11.

Kreuter A, Krieg T, Worm M, Wenzel J, Moinzadeh P, Kuhn A, et al. German guidelines for the diagnosis and therapy of localized scleroderma. J Dtsch Dermatol Ges. 2016;14:199–216. https://doi.org/10.1111/ddg.12724.CrossRefPubMed

12.

Janowski K, Steuden S, Bereza B. The polish version of Skindex-29: psychometric properties of an instrument to measure quality of life in dermatology. Postepy Dermatol Alergol. 2014;31:12–20. https://doi.org/10.5114/pdia.2014.40654.CrossRefPubMedPubMedCentral

13.

Chren MM, Lasek RJ, Quinn LM, Mostow EN, Zyzanski SJ. Skindex, a quality-of-life measure for patients with skin disease: reliability, validity, and responsiveness. J Invest Dermatol. 1996;107:707–13. https://doi.org/10.1111/1523-1747.ep12365600.CrossRefPubMed

14.

Abeni D, Picardi A, Pasquini P, Melchi CF, Chren MM. Further evidence of the validity and reliability of the Skindex-29: an Italian study on 2,242 dermatological outpatients. Dermatology. 2002;204:43–9. https://doi.org/10.1159/000051809.CrossRefPubMed

15.

Both H, Essink-Bot ML, Busschbach J, Nijsten T. Critical review of generic and dermatology-specific health-related quality of life instruments. J Invest Dermatol. 2007;127:2726–39. https://doi.org/10.1038/sj.jid.5701142.CrossRefPubMed

16.

Gambichler T, Othlinghaus N, Tomi NS, Boms S, Skrygan M, Altmeyer P, et al. Medium-dose ultraviolet ( UV ) A 1 vs . narrowband UVB phototherapy in atopic eczema : a randomized crossover study. Br J Dermatol. 2009;160:652–8. https://doi.org/10.1111/j.1365-2133.2008.08984.x.CrossRefPubMed

17.

Hayashi N, Kawashima M. Efficacy of oral antibiotics on acne vulgaris and their effects on quality of life: a multicenter randomized controlled trial using minocycline, roxithromycin and faropenem. J Dermatol. 2011;38:111–9. https://doi.org/10.1111/j.1346-8138.2010.00969.x.CrossRefPubMed

18.

Ortonne JP, Ganslandt C, Tan J, Nordin P, Kragballe K, Segaert S. Quality of life in patients with scalp psoriasis treated with calcipotriol/betamethasone dipropionate scalp formulation: a randomized controlled trial. J Eur Acad Dermatol Venereol. 2009;23:919–26. https://doi.org/10.1111/j.1468-3083.2009.03221.x.CrossRefPubMed

19.

Careta MF, Romiti R. Localized scleroderma: clinical spectrum and therapeutic update. An Bras Dermatol. 2015;90:62–73. https://doi.org/10.1590/abd1806-4841.20152890.CrossRefPubMedPubMedCentral

20.

Brady TF, Konkle T, Gill J, Oliva A, Alvarez GA. Visual long-term memory has the same limit on fidelity as visual working memory. Psychol Sci. 2013;24:981–90. https://doi.org/10.1177/0956797612465439.CrossRefPubMed

21.

Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977;33:159–74. https://doi.org/10.2307/2529310.CrossRef

22.

Mukaka MM. Statistics corner: a guide to appropriate use of correlation coefficient in medical research. Malawi Med J. 2012;24:69–71. https://www.ajol.info/index.php/mmj/article/view/81576/71739.PubMedPubMedCentral

23.

Ardalan K, Zigler CK, Torok KS. Predictors of longitudinal quality of life in juvenile localized scleroderma. Arthritis Care Res (Hoboken). 2017;69:1082–7. https://doi.org/10.1002/acr.23101.CrossRef

24.

Klimas NK, Shedd AD, Bernstein IH, Jacobe H. Health-related quality of life in morphoea. Br J Dermatol. 2015;172:1329–37. https://doi.org/10.1111/bjd.13572.CrossRefPubMedPubMedCentral

25.

Lis-Święty A, Janicka I, Skrzypek-Salamon A, Brzezińska-Wcisło L. A systematic review of tools for determining activity of localized scleroderma in paediatric and adult patients. J Eur Acad Dermatol Venereol. 2017;31:30–7. https://doi.org/10.1111/jdv.13790.CrossRefPubMed

26.

Das S, Bernstein I, Jacobe H. Correlates of self-reported quality of life in adults and children with morphea. J Am Acad Dermatol. 2014;70:904–10. https://doi.org/10.1016/j.jaad.2013.11.037.CrossRefPubMedPubMedCentral

27.

Okiyama N, Asano Y, Hamaguchi Y, Jinnin M, Motegi SI, Koizumi H, et al. Impact of a new simplified disability scoring system for adult patients with localized scleroderma. J Dermatol. 2018;45:431–5. https://doi.org/10.1111/1346-8138.14214.CrossRefPubMed

Title: Localized Scleroderma Cutaneous Assessment Tool (LoSCAT) adapted for use in adult patients: report from an initial validation study
Authors: Alina Skrzypek-Salamon
Anna Lis-Święty
Irmina Ranosz-Janicka
Ligia Brzezińska-Wcisło
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: Health and Quality of Life Outcomes / Issue 1/2018
Electronic ISSN: 1477-7525
DOI: https://doi.org/10.1186/s12955-018-1010-z

ACC 2024 Congress

Springer Medicine

Localized Scleroderma Cutaneous Assessment Tool (LoSCAT) adapted for use in adult patients: report from an initial validation study

Abstract

Background

Methods

Results

Conclusions

ACC 2024 Congress

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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