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Cardiovascular Ultrasound
Published in: Cardiovascular Ultrasound 1/2015

Open Access 01-12-2015 | Research

Brachial artery endothelial function is stable across the morning in young men

Authors: Saurabh S. Thosar, Chad C. Wiggins, Steven A. Shea, Janet P. Wallace

Published in: Cardiovascular Ultrasound | Issue 1/2015

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Abstract

Background

The morning hours are associated with increased cardiovascular (CV) risk, and vascular endothelial function (VEF) is a strong predictor of CV disease. A diurnal rhythm in VEF has been established but the morning variation in VEF is not well-documented. Thus, we tested if VEF is impaired across the vulnerable morning period.

Methods

After overnight fasts, eight healthy men (age 26.3 ± 3 yr) underwent assessments of VEF under standardized testing conditions every 2 h from 0700 to 1300 h on two separate days. VEF was estimated following 5 min brachial artery occlusions by hyperemic flow-mediated dilation (FMD).

Results

There was no significant change in FMD or hyperemic shear stimulus across the 6 h vulnerable period on either day, despite changes in physical activity and meals across these periods.

Conclusion

In this healthy group of young men, VEF is stable across the vulnerable morning period when typical behaviors occurred (breakfast and physical activity). Future research should focus on the roles of sleep, physical inactivity during sleep and endogenous circadian rhythm in VEF.
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Metadata
Title
Brachial artery endothelial function is stable across the morning in young men
Authors
Saurabh S. Thosar
Chad C. Wiggins
Steven A. Shea
Janet P. Wallace
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Cardiovascular Ultrasound / Issue 1/2015
Electronic ISSN: 1476-7120
DOI
https://doi.org/10.1186/s12947-015-0036-1

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