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Open Access 01-12-2015 | Review

The role of the insulin-like growth factor-1 system in breast cancer

Authors: Panagiotis F Christopoulos, Pavlos Msaouel, Michael Koutsilieris

Published in: Molecular Cancer | Issue 1/2015

Abstract

IGF-1 is a potent mitogen of major importance in the mammary gland. IGF-1 binding to the cognate receptor, IGF-1R, triggers a signaling cascade leading to proliferative and anti-apoptotic events. Although many of the relevant molecular pathways and intracellular cascades remain to be elucidated, a growing body of evidence points to the important role of the IGF-1 system in breast cancer development, progression and metastasis. IGF-1 is a point of convergence for major signaling pathways implicated in breast cancer growth. In this review, we provide an overview and concise update on the function and regulation of IGF-1 as well as the role it plays in breast malignancies.

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Title: The role of the insulin-like growth factor-1 system in breast cancer
Authors: Panagiotis F Christopoulos
Pavlos Msaouel
Michael Koutsilieris
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: Molecular Cancer / Issue 1/2015
Electronic ISSN: 1476-4598
DOI: https://doi.org/10.1186/s12943-015-0291-7

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