Skip to main content
Top
Published in: Malaria Journal 1/2018

Open Access 01-12-2018 | Case report

Two clusters of Plasmodium knowlesi cases in a malaria elimination area, Sabang Municipality, Aceh, Indonesia

Authors: Herdiana Herdiana, Irnawati Irnawati, Farah Novita Coutrier, Alfian Munthe, Mardiati Mardiati, Titik Yuniarti, Elvieda Sariwati, Maria Endang Sumiwi, Rintis Noviyanti, Paul Pronyk, William A. Hawley

Published in: Malaria Journal | Issue 1/2018

Login to get access

Abstract

In malaria elimination areas, malaria cases are sporadic and consist predominantly of imported cases. Plasmodium knowlesi cases have been reported throughout Southeast Asia where long-tailed and pig-tailed macaques and Anopheles leucosphyrus group mosquitoes are sympatric. The limitation of microscopic examination to diagnose P. knowlesi is well known. In consequence, no P. knowlesi case has previously been reported from routine health facility-based case finding activities in Indonesia. This report describes two clusters of unexpected locally acquired P. knowlesi cases found in an area where Plasmodium falciparum and Plasmodium vivax infection had been eliminated in Sabang Municipality, Aceh, Indonesia. The difficulties in diagnosis and response illustrate challenges that Southeast Asian countries will increasingly face as the formerly common malaria parasites P. falciparum and P. vivax are gradually eliminated from the region.
Literature
2.
go back to reference Herdiana H, Fuad A, Asih PB, Zubaedah S, Arisanti RR, Syafruddin D, et al. Progress towards malaria elimination in Sabang Municipality, Aceh, Indonesia. Malar J. 2013;12:42.CrossRefPubMedPubMedCentral Herdiana H, Fuad A, Asih PB, Zubaedah S, Arisanti RR, Syafruddin D, et al. Progress towards malaria elimination in Sabang Municipality, Aceh, Indonesia. Malar J. 2013;12:42.CrossRefPubMedPubMedCentral
4.
go back to reference BPS-Kota Sabang. Kota Sabang dalam angka 2017 [BPS-Statistics of Sabang Municipality. Sabang Municipality in figures 2017]. Kota Sabang, BPS-Kota Sabang; 2017 (in Bahasa). BPS-Kota Sabang. Kota Sabang dalam angka 2017 [BPS-Statistics of Sabang Municipality. Sabang Municipality in figures 2017]. Kota Sabang, BPS-Kota Sabang; 2017 (in Bahasa).
5.
go back to reference Dinas Kehutanan Aceh. Statistik Kehutanan 2015 [Provincial Forestry Office. Statistics of Forest 2015]. Banda Aceh, Dinas Kehutanan Aceh; 2016 (in Bahasa). Dinas Kehutanan Aceh. Statistik Kehutanan 2015 [Provincial Forestry Office. Statistics of Forest 2015]. Banda Aceh, Dinas Kehutanan Aceh; 2016 (in Bahasa).
6.
go back to reference Fadwa F. Population sturcture and habitat stratification of long-tailed macaca (Macaca Fascicularis) at protection forest of Iboih village Sabang Municipal. Banda aceh: Fakultas KIP Universitas Syiah Kuala; 2016 (in Bahasa). Fadwa F. Population sturcture and habitat stratification of long-tailed macaca (Macaca Fascicularis) at protection forest of Iboih village Sabang Municipal. Banda aceh: Fakultas KIP Universitas Syiah Kuala; 2016 (in Bahasa).
7.
go back to reference Dinas Kesehatan Kabupaten Bireun. Profil Kesehatan Kabupaten Bireun 2015 [District Health Office of Bireun. Health Profile of Bireun District 2015]. Bireun, Dinas Kesehatan Kabupaten Bireun; 2015 (in Bahasa). Dinas Kesehatan Kabupaten Bireun. Profil Kesehatan Kabupaten Bireun 2015 [District Health Office of Bireun. Health Profile of Bireun District 2015]. Bireun, Dinas Kesehatan Kabupaten Bireun; 2015 (in Bahasa).
8.
go back to reference Coutrier F, Cotter C, Tirta Y, Schwartz A, Zarlinda I, Basri H, et al. Serial molecular identification to confirm the presence of Plasmodium knowlesi in Indonesia. Poster session presented at: 64th Annual Meeting of The American Society for Tropical Medicine and Hygiene; 2015 Oct 25–29; Philadelphia, PA. Coutrier F, Cotter C, Tirta Y, Schwartz A, Zarlinda I, Basri H, et al. Serial molecular identification to confirm the presence of Plasmodium knowlesi in Indonesia. Poster session presented at: 64th Annual Meeting of The American Society for Tropical Medicine and Hygiene; 2015 Oct 25–29; Philadelphia, PA.
9.
go back to reference Herdiana H, Cotter C, Coutrier FN, Zarlinda I, Zelman BW, Tirta YK, et al. Malaria risk factor assessment using active and passive surveillance data from Aceh Besar, Indonesia, a low endemic, malaria elimination setting with Plasmodium knowlesi, Plasmodium vivax, and Plasmodium falciparum. Malar J. 2016;15:468.CrossRefPubMedPubMedCentral Herdiana H, Cotter C, Coutrier FN, Zarlinda I, Zelman BW, Tirta YK, et al. Malaria risk factor assessment using active and passive surveillance data from Aceh Besar, Indonesia, a low endemic, malaria elimination setting with Plasmodium knowlesi, Plasmodium vivax, and Plasmodium falciparum. Malar J. 2016;15:468.CrossRefPubMedPubMedCentral
10.
go back to reference Dinkes Provinsi Aceh. Field manual of epidemiology investigation of malaria for primary health center and district health office staff. Aceh: Dinas Kesehatan Provinsi Aceh; 2012 (in Bahasa). Dinkes Provinsi Aceh. Field manual of epidemiology investigation of malaria for primary health center and district health office staff. Aceh: Dinas Kesehatan Provinsi Aceh; 2012 (in Bahasa).
11.
go back to reference Moyes CL, Shearer FM, Huang Z, Wiebe A, Gibson HS, Nijman V, et al. Predicting the geographical distributions of the macaque hosts and mosquito vectors of Plasmodium knowlesi malaria in forested and non-forested areas. Parasit Vectors. 2016;9:242.CrossRefPubMedPubMedCentral Moyes CL, Shearer FM, Huang Z, Wiebe A, Gibson HS, Nijman V, et al. Predicting the geographical distributions of the macaque hosts and mosquito vectors of Plasmodium knowlesi malaria in forested and non-forested areas. Parasit Vectors. 2016;9:242.CrossRefPubMedPubMedCentral
12.
go back to reference Barber BE, William T, Dhararaj P, Anderios F, Grigg MJ, Yeo TW, et al. Epidemiology of Plasmodium knowlesi malaria in north-east Sabah, Malaysia: Family clusters and wide age distribution. Malar J. 2012;11:401.CrossRefPubMedPubMedCentral Barber BE, William T, Dhararaj P, Anderios F, Grigg MJ, Yeo TW, et al. Epidemiology of Plasmodium knowlesi malaria in north-east Sabah, Malaysia: Family clusters and wide age distribution. Malar J. 2012;11:401.CrossRefPubMedPubMedCentral
13.
go back to reference Vythilingam I, Lim YA, Venugopalan B, Ngui R, Leong CS, Wong ML, et al. Plasmodium knowlesi malaria an emerging public health problem in Hulu Selangor, Selangor, Malaysia (2009–2013): epidemiologic and entomologic analysis. Parasit Vectors. 2014;7:436.CrossRefPubMedPubMedCentral Vythilingam I, Lim YA, Venugopalan B, Ngui R, Leong CS, Wong ML, et al. Plasmodium knowlesi malaria an emerging public health problem in Hulu Selangor, Selangor, Malaysia (2009–2013): epidemiologic and entomologic analysis. Parasit Vectors. 2014;7:436.CrossRefPubMedPubMedCentral
14.
go back to reference Barber BE, William T, Grigg MJ, Yeo TW, Anstey NM. Limitations of microscopy to differentiate Plasmodium species in a region co-endemic for Plasmodium falciparum, Plasmodium vivax and Plasmodium knowlesi. Malar J. 2013;12:8.CrossRefPubMedPubMedCentral Barber BE, William T, Grigg MJ, Yeo TW, Anstey NM. Limitations of microscopy to differentiate Plasmodium species in a region co-endemic for Plasmodium falciparum, Plasmodium vivax and Plasmodium knowlesi. Malar J. 2013;12:8.CrossRefPubMedPubMedCentral
15.
go back to reference Cox-Singh J, Davis TM, Lee KS, Shamsul SS, Matusop A, Ratnam S, et al. Plasmodium knowlesi malaria in humans is widely distributed and potentially life threatening. Clin Infect Dis. 2008;46:165–71.CrossRefPubMedPubMedCentral Cox-Singh J, Davis TM, Lee KS, Shamsul SS, Matusop A, Ratnam S, et al. Plasmodium knowlesi malaria in humans is widely distributed and potentially life threatening. Clin Infect Dis. 2008;46:165–71.CrossRefPubMedPubMedCentral
16.
17.
go back to reference Sulistyaningsih E, Fitri LE, Löscher T, Berens-Riha N. Diagnostic difficulties with Plasmodium knowlesi infection in humans. Emerg Infect Dis. 2010;16:1033–4.CrossRefPubMedPubMedCentral Sulistyaningsih E, Fitri LE, Löscher T, Berens-Riha N. Diagnostic difficulties with Plasmodium knowlesi infection in humans. Emerg Infect Dis. 2010;16:1033–4.CrossRefPubMedPubMedCentral
18.
go back to reference Lubis IND, Wijaya H, Lubis M, Lubis CP, Divis PCS, Beshir KB, et al. Contribution of Plasmodium knowlesi to multispecies human malaria infections in North Sumatera, Indonesia. J Infect Dis. 2017;215:1148–55.CrossRefPubMedPubMedCentral Lubis IND, Wijaya H, Lubis M, Lubis CP, Divis PCS, Beshir KB, et al. Contribution of Plasmodium knowlesi to multispecies human malaria infections in North Sumatera, Indonesia. J Infect Dis. 2017;215:1148–55.CrossRefPubMedPubMedCentral
19.
go back to reference Menteri Kesehatan RI. Peraturan tatalaksana malaria [Management malaria case regulation]. Vol. Nomor 5 Tahun 2013, Indonesia, Kementerian Kesehatan Republik; 2013 (in Bahasa). Menteri Kesehatan RI. Peraturan tatalaksana malaria [Management malaria case regulation]. Vol. Nomor 5 Tahun 2013, Indonesia, Kementerian Kesehatan Republik; 2013 (in Bahasa).
20.
go back to reference Who. Guidelines for the treatment of malaria. 3rd ed. Geneva: World Health Organization; 2015. Who. Guidelines for the treatment of malaria. 3rd ed. Geneva: World Health Organization; 2015.
21.
go back to reference Barber BE, Grigg MJ, William T, Yeo TW, Anstey NM. The Treatment of Plasmodium knowlesi Malaria. Trends Parasitol. 2017;33:242–53.CrossRefPubMed Barber BE, Grigg MJ, William T, Yeo TW, Anstey NM. The Treatment of Plasmodium knowlesi Malaria. Trends Parasitol. 2017;33:242–53.CrossRefPubMed
22.
go back to reference Smrkovski LL, Hoffman SL. Purnomo, Hussein RP, Masbar S, Kurniawan L. Chloroquine resistant Plasmodium falciparum on the island of Flores, Indonesia. Trans R Soc Trop Med Hyg. 1983;77:459–62.CrossRefPubMed Smrkovski LL, Hoffman SL. Purnomo, Hussein RP, Masbar S, Kurniawan L. Chloroquine resistant Plasmodium falciparum on the island of Flores, Indonesia. Trans R Soc Trop Med Hyg. 1983;77:459–62.CrossRefPubMed
23.
go back to reference Schwartz IK, Lackritz EM, Patchen LC. Chloroquine-Resistant Plasmodium vivax from Indonesia. N Engl J Med. 1991;324:927.CrossRefPubMed Schwartz IK, Lackritz EM, Patchen LC. Chloroquine-Resistant Plasmodium vivax from Indonesia. N Engl J Med. 1991;324:927.CrossRefPubMed
24.
go back to reference Fryauff DJ, Tuti S, Mardi A, Masbar S, Patipelohi R, Leksana B, et al. Chloroquine-resistant Plasmodium vivax in transmigration settlements of West Kalimantan, Indonesia. Am J Trop Med Hyg. 1998;59:513–8.CrossRefPubMed Fryauff DJ, Tuti S, Mardi A, Masbar S, Patipelohi R, Leksana B, et al. Chloroquine-resistant Plasmodium vivax in transmigration settlements of West Kalimantan, Indonesia. Am J Trop Med Hyg. 1998;59:513–8.CrossRefPubMed
25.
go back to reference Maguire JD, Sumawinata IW, Masbar S, Laksana B, Prodjodipuro P, Sismadi P, et al. Chloroquine-resistant Plasmodium malariae in south Sumatra, Indonesia. Lancet. 2002;360:58–60.CrossRefPubMed Maguire JD, Sumawinata IW, Masbar S, Laksana B, Prodjodipuro P, Sismadi P, et al. Chloroquine-resistant Plasmodium malariae in south Sumatra, Indonesia. Lancet. 2002;360:58–60.CrossRefPubMed
26.
go back to reference WHO. Meeting report expert consultation on Plasmodium knowlesi malaria to guide malaria elimination strategies. In: World Health Organization Regional Office for the Western Pacific. Kota Kinabalu, Malaysia; 2017. WHO. Meeting report expert consultation on Plasmodium knowlesi malaria to guide malaria elimination strategies. In: World Health Organization Regional Office for the Western Pacific. Kota Kinabalu, Malaysia; 2017.
27.
go back to reference Barber BE, William T, Grigg MJ, Menon J, Auburn S, Marfurt J, et al. A prospective comparative study of knowlesi, falciparum, and vivax Malaria in Sabah, Malaysia: high proportion with severe disease from Plasmodium knowlesi and Plasmodium vivax but no mortality with early referral and artesunate therapy. Clin Infect Dis. 2013;56:383–97.CrossRefPubMed Barber BE, William T, Grigg MJ, Menon J, Auburn S, Marfurt J, et al. A prospective comparative study of knowlesi, falciparum, and vivax Malaria in Sabah, Malaysia: high proportion with severe disease from Plasmodium knowlesi and Plasmodium vivax but no mortality with early referral and artesunate therapy. Clin Infect Dis. 2013;56:383–97.CrossRefPubMed
28.
go back to reference William T, Menon J, Rajahram G, Chan L, Ma G, Donaldson S, et al. Severe Plasmodium knowlesi malaria in a tertiary care hospital, Sabah. Malaysia. Emerg Infect Dis. 2011;17:1248–55.CrossRefPubMed William T, Menon J, Rajahram G, Chan L, Ma G, Donaldson S, et al. Severe Plasmodium knowlesi malaria in a tertiary care hospital, Sabah. Malaysia. Emerg Infect Dis. 2011;17:1248–55.CrossRefPubMed
Metadata
Title
Two clusters of Plasmodium knowlesi cases in a malaria elimination area, Sabang Municipality, Aceh, Indonesia
Authors
Herdiana Herdiana
Irnawati Irnawati
Farah Novita Coutrier
Alfian Munthe
Mardiati Mardiati
Titik Yuniarti
Elvieda Sariwati
Maria Endang Sumiwi
Rintis Noviyanti
Paul Pronyk
William A. Hawley
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Malaria Journal / Issue 1/2018
Electronic ISSN: 1475-2875
DOI
https://doi.org/10.1186/s12936-018-2334-1

Other articles of this Issue 1/2018

Malaria Journal 1/2018 Go to the issue