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Cancer Cell International
Published in: Cancer Cell International 1/2020

Open Access 01-12-2020 | Lymphoma | Review

Combination strategies to overcome resistance to the BCL2 inhibitor venetoclax in hematologic malignancies

Authors: XiaoYan Yue, Qingxiao Chen, JingSong He

Published in: Cancer Cell International | Issue 1/2020

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Abstract

Venetoclax has been approved by the United States Food and Drug Administration since 2016 as a monotherapy for treating patients with relapsed/refractory chronic lymphocytic leukemia having 17p deletion. It has led to a breakthrough in the treatment of hematologic malignancies in recent years. However, unfortunately, resistance to venetoclax is inevitable. Multiple studies confirmed that the upregulation of the anti-apoptotic proteins of the B-cell lymphoma 2 (BCL2) family mediated by various mechanisms, such as tumor microenvironment, and the activation of intracellular signaling pathways were the major factors leading to resistance to venetoclax. Therefore, only targeting BCL2 often fails to achieve the expected therapeutic effect. Based on the mechanism of resistance in specific hematologic malignancies, the combination of specific drugs with venetoclax was a clinically optional treatment strategy for overcoming resistance to venetoclax. This study aimed to summarize the possible resistance mechanisms of various hematologic tumors to venetoclax and the corresponding clinical strategies to overcome resistance to venetoclax in hematologic malignancies.
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Metadata
Title
Combination strategies to overcome resistance to the BCL2 inhibitor venetoclax in hematologic malignancies
Authors
XiaoYan Yue
Qingxiao Chen
JingSong He
Publication date
01-12-2020

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