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Cancer Cell International
Published in: Cancer Cell International 1/2019

Open Access 01-12-2019 | Gallbladder Cancer | Primary research

New insights into the association between AXIN2 148 C/T, 1365 C/T, and rs4791171 A/G variants and cancer risk

Authors: Bin Xu, Wei Yuan, Li Shi, Li Zuo, Xing-Yu Wu, Wei Zhang, Qiaxian Wen

Published in: Cancer Cell International | Issue 1/2019

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Abstract

Background

Many epidemiological studies have investigated association of AXIN2 variants on overall cancer risks; however, the available results remain inconsistent.

Methods

An updated analysis was conducted to ascertain a more accurate estimation of the correlation between AXIN2 148 C/T, 1365 C/T, and rs4791171 A/G polymorphisms and cancer risk. We also used in silico tools to assess the effect of AXIN2 expression on cancer susceptibility and overall survival time.

Results

A total of 4281 cases and 3955 control participants were studied. The overall results indicated that AXIN2 148 C/T variant was associated with cancer risk (allelic contrast: OR = 0.88, 95% CI 0.77–0.99, Pheterogeneity = 0.004; dominant model: OR = 0.82, 95% CI 0.69–0.96, Pheterogeneity = 0.022), especially for lung and prostate adenocarcinoma. Similar results were observed in 1365 C/T polymorphism (OR = 0.71, 95% CI 0.61–0.98, Pheterogeneity = 0.873; dominant model: OR = 0.66, 95% CI 0.47–0.94, Pheterogeneity = 0.775). Moreover, in subgroup analysis by ethnicity, similar findings were obtained for Asian and Caucasian populations. Results from in silico tools suggested that AXIN2 expressions in lung adenocarcinoma were lower than that in normal group.

Conclusions

Our findings indicated that AXIN2 148 C/T and 1365 C/T variants may be associated with decreased cancer susceptibility.
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Metadata
Title
New insights into the association between AXIN2 148 C/T, 1365 C/T, and rs4791171 A/G variants and cancer risk
Authors
Bin Xu
Wei Yuan
Li Shi
Li Zuo
Xing-Yu Wu
Wei Zhang
Qiaxian Wen
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2019
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-019-0840-z

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