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Cancer Cell International
Published in: Cancer Cell International 1/2019

Open Access 01-12-2019 | Esophageal Cancer | Primary research

Over-expression of Nectin-4 promotes progression of esophageal cancer and correlates with poor prognosis of the patients

Authors: Haifeng Deng, Hongbing Shi, Lujun Chen, You Zhou, Jingting Jiang

Published in: Cancer Cell International | Issue 1/2019

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Abstract

Background

Nectin-4, also known as PVRL4 (poliovirus-receptor-like 4), is specifically expressed in the embryo and placenta. Recent studies have reported that the Nectin-4 is over-expressed in multiple human cancers, and such abnormal expression is associated with cancer progression and poor prognosis of the patients. In the present study, we aimed to characterize the expression pattern of Nectin-4 in human esophageal cancer (EC) tissues, and to investigate its clinical implications, prognostic value and regulatory effects on cellular functions of EC cells.

Methods

In the present study, we first examined Nectin-4 expression in human EC tissues by using immunohistochemistry (IHC) assay and analyzed the clinical associations. Then the cellular studies in vitro and the nude mice tumor model in vivo were used to examine the regulatory role of Nectin-4 in the progression of EC.

Results

Our results demonstrated that over-expression of Nectin-4 in human EC tissues was significantly associated with tumor size, depth of tumor invasion, and poor prognosis of the patients. The intervention of Nectin-4 expression in EC cell lines showed that the increased Nectin-4 expression could significantly promote the cell viability, migration, invasion and tumor formation.

Conclusions

Our present data unveiled that Nectin-4 played an important role in tumor biology and could serve as a useful prognostic predictor of human EC.
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Metadata
Title
Over-expression of Nectin-4 promotes progression of esophageal cancer and correlates with poor prognosis of the patients
Authors
Haifeng Deng
Hongbing Shi
Lujun Chen
You Zhou
Jingting Jiang
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2019
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-019-0824-z

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