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Cancer Cell International
Published in: Cancer Cell International 1/2018

Open Access 01-12-2018 | Review

PEG10 as an oncogene: expression regulatory mechanisms and role in tumor progression

Authors: Tian Xie, Shan Pan, Hang Zheng, Zilv Luo, Kingsley M. Tembo, Muhammad Jamal, Zhongyang Yu, Yao Yu, Jing Xia, Qian Yin, Meng Wang, Wen Yuan, Qiuping Zhang, Jie Xiong

Published in: Cancer Cell International | Issue 1/2018

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Abstract

Cancer is a major public health problem as one of the leading causes of death worldwide. Deciphering the molecular regulation mechanisms of tumor progression can make way for tumor diagnosis and therapy. Paternally expressed gene 10 (PEG10), located on human chromosome 7q21.3, has turned out to be an oncogene implicated in the proliferation, apoptosis and metastasis of tumors. PEG10 has been found to be positively expressed in a variety of cancers with seemingly complex expression regulation mechanisms. In this review, we focus on the most vital factors influencing PEG10 expression and recapitulate some of the currently known and potential mechanisms of PEG10 affecting tumor progression, as understanding the molecular regulatory mechanisms of tumor progression can provide potential PEG10 related diagnosis and biomarker specific targeted therapies.
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Metadata
Title
PEG10 as an oncogene: expression regulatory mechanisms and role in tumor progression
Authors
Tian Xie
Shan Pan
Hang Zheng
Zilv Luo
Kingsley M. Tembo
Muhammad Jamal
Zhongyang Yu
Yao Yu
Jing Xia
Qian Yin
Meng Wang
Wen Yuan
Qiuping Zhang
Jie Xiong
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2018
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-018-0610-3

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