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Cancer Cell International
Published in: Cancer Cell International 1/2018

Open Access 01-12-2018 | Primary Research

Prognostic value of long non-coding RNA BLACAT1 in patients with papillary thyroid carcinoma

Authors: Denghui Liao, Gang Lv, Ting Wang, Jie Min, Yadong Wang, Shengchun Liu

Published in: Cancer Cell International | Issue 1/2018

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Abstract

Background

Long noncoding RNAs (lncRNAs) have been reported to have potential diagnostic and prognostic values for numerous cancers. However, the plasma expression of lncRNA BLACAT1 and its clinical value in patients with papillary thyroid cancer (PTC) remain unknown.

Methods

The expression profile of BLACAT1 in 87 PTC patients (case group) and 36 patients with nodular goiter (control group) were investigated by qRT-PCR. The Kaplan–Meier method was used for RFS curves, and the univariate survival differences were analyzed by the log-rank test.

Results

BLACAT1 expression was downregulated in the plasma of case group compared with control group (P = 0.003). We also found that low plasma BLACAT1 expression was correlated with lymph node metastasis (LNM) (P < 0.001). Multivariate analysis showed that BLACAT1 was an independent risk factor for lymph node metastasis and gender (P < 0.05). The area under the ROC curve for BLACAT1 was 0.825 in LNM prediction (P < 0.001).

Conclusion

The present study demonstrated that BLACAT1 could act as a possible suppressor gene in PTC and may serve as a potential biomarker for prognosis prediction of PTC.
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Metadata
Title
Prognostic value of long non-coding RNA BLACAT1 in patients with papillary thyroid carcinoma
Authors
Denghui Liao
Gang Lv
Ting Wang
Jie Min
Yadong Wang
Shengchun Liu
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2018
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-018-0544-9

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