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Cancer Cell International
Published in: Cancer Cell International 1/2015

Open Access 01-12-2015 | Review

Xanthorrhizol: a review of its pharmacological activities and anticancer properties

Authors: Seok Fang Oon, Meenakshii Nallappan, Thiam Tsui Tee, Shamarina Shohaimi, Nur Kartinee Kassim, Mohd Shazrul Fazry Sa’ariwijaya, Yew Hoong Cheah

Published in: Cancer Cell International | Issue 1/2015

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Abstract

Xanthorrhizol (XNT) is a bisabolane-type sesquiterpenoid compound extracted from Curcuma xanthorrhiza Roxb. It has been well established to possess a variety of biological activities such as anticancer, antimicrobial, anti-inflammatory, antioxidant, antihyperglycemic, antihypertensive, antiplatelet, nephroprotective, hepatoprotective, estrogenic and anti-estrogenic effects. Since many synthetic drugs possess toxic side effects and are unable to support the increasing prevalence of disease, there is significant interest in developing natural product as new therapeutics. XNT is a very potent natural bioactive compound that could fulfil the current need for new drug discovery. Despite its importance, a comprehensive review of XNT’s pharmacological activities has not been published in the scientific literature to date. Here, the present review aims to summarize the available information in this area, focus on its anticancer properties and indicate the current status of the research. This helps to facilitate the understanding of XNT’s pharmacological role in drug discovery, thus suggesting areas where further research is required.
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Metadata
Title
Xanthorrhizol: a review of its pharmacological activities and anticancer properties
Authors
Seok Fang Oon
Meenakshii Nallappan
Thiam Tsui Tee
Shamarina Shohaimi
Nur Kartinee Kassim
Mohd Shazrul Fazry Sa’ariwijaya
Yew Hoong Cheah
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2015
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-015-0255-4

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