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Cancer Cell International
Published in: Cancer Cell International 1/2015

Open Access 01-12-2015 | Review

Understanding the colon cancer stem cells and perspectives on treatment

Authors: Elsa N Garza-Treviño, Salvador L Said-Fernández, Herminia G Martínez-Rodríguez

Published in: Cancer Cell International | Issue 1/2015

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Abstract

An area of research that has been recently gaining attention is the relationship between cancer stem cell (CSC) biology and chemo-resistance in colon cancer patients. It is well recognized that tumor initiation, growth, invasion and metastasis are promoted by CSCs. An important reason for the widespread interest in the CSC model is that it can comprehensibly explain essential and poorly understood clinical events, such as therapy resistance, minimal residual disease, and tumor recurrence. This review discusses the recent advances in colon cancer stem cell research, the genes responsible for CSC chemoresistance, and new therapies against CSCs.
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Metadata
Title
Understanding the colon cancer stem cells and perspectives on treatment
Authors
Elsa N Garza-Treviño
Salvador L Said-Fernández
Herminia G Martínez-Rodríguez
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2015
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-015-0163-7

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