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Cancer Cell International
Published in: Cancer Cell International 1/2015

Open Access 01-12-2015 | Review

The multifaceted role of CD146/MCAM in the promotion of melanoma progression

Authors: Xing Lei, Ce-Wen Guan, Yang Song, Huan Wang

Published in: Cancer Cell International | Issue 1/2015

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Abstract

Human malignant melanoma is a common primary malignant cutaneous tumour derived from transformed epidermal melanocytes. Patients with melanoma have a high rate of mortality due to resistance to chemotherapeutic drugs, a major obstacle to a successful treatment. Several reports have suggested that CD146 plays an important role as a signalling molecule in human melanoma. This role includes CD146 as a participant in inflammation, differentiation, adhesion, tumourigenicity, metastasis, invasion and angiogenesis among other processes, which suggests that this molecule promotes the progression of human melanoma as a multifaceted regulator. In this article, we explore the effects and corresponding mechanisms with respect to the role of CD146/MUC18 in the promotion of human melanoma progression. Collectively, the studies indicated that targeting CD146, because it is a suitable marker of poor patient outcome, might be useful in the design of future strategies for the prevention and treatment of human melanoma.
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Metadata
Title
The multifaceted role of CD146/MCAM in the promotion of melanoma progression
Authors
Xing Lei
Ce-Wen Guan
Yang Song
Huan Wang
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2015
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-014-0147-z

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